Studies on isolated human skeletal muscle fibersIncluding a proposed pattern of nuclear distribution and a concept of nuclear territories

Landing, Benjamin H.; Dixon, Lianne G.; Wells, Theadis R.

doi:10.1016/s0046-8177(74)80023-7

Cited by 44 publications

(20 citation statements)

References 7 publications

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“…Moreover, Allen et al (1995Allen et al ( , 1996 have demonstrated that the myonuclear number was modulated upwards and downwards during hypertrophy and atrophy, respectively, in cats. Our finding is in agreement with the hypothesis that larger fibres would contain more nuclei (Giddings and Gonyea 1992;Landing et al 1974). However, it should be mentioned that in all previous studies, no distinction was made between myonuclei and satellite cells.…”

Section: Discussionsupporting

confidence: 93%

Cellular adaptation of the trapezius muscle in strength-trained athletes

Kadi¹,

Eriksson²,

Holmner

et al. 1999

Histochemistry and Cell Biology

157

111

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The aim of this study was to elucidate the cellular events that occur in the trapezius muscle following several years of strength training. In muscle biopsies from ten elite power lifters (PL) and six control subjects (C), several parameters were studied: cross-sectional area of muscle fibres, myosin heavy chain composition (MHC) and capillary supply [capillaries around fibres (CAF) and CAF/fibre area]. A method was also developed for counting the number of myonuclei and satellite cell nuclei. The proportion of fibres expressing MHC IIA, the cross-sectional area of each fibre type and the number of myonuclei, satellite cells and fibres expressing markers for early myogenesis were significantly higher in PL than in C (P<0.05). A significant correlation between the myonuclear number and the cross-sectional area was observed. Since myonuclei in mature muscle fibres are not able to divide, we suggest that the incorporation of satellite cell nuclei into muscle fibres resulted in the maintenance of a constant nuclear to cytoplasmic ratio. The presence of small diameter fibres expressing markers for early myogenesis indicates the formation of new muscle fibres.

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Section: Discussionsupporting

confidence: 93%

Cellular adaptation of the trapezius muscle in strength-trained athletes

Kadi¹,

Eriksson²,

Holmner

et al. 1999

Histochemistry and Cell Biology

157

111

View full text Add to dashboard Cite

show abstract

“…This and other studies showing changes in the numbers of nuclei with hypertrophy indicate that the nucleus is functioning almost maximally in terms of the capacity or area of its domain; therefore, a strict limit to the nuclear domain must exist within the muscle fiber. The concept of nuclear domains has been discussed for some time (Landing et al, 1974), but experimental evidence for this concept has only recently begun accumulating Hall, 1989, 1992).…”

Section: Discussionmentioning

confidence: 99%

Myonuclear loss in atrophied soleus muscle fibers

et al. 1997

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“…Muscle wasting and weakness are also associated with critical and chronic illness. As mentioned earlier, a skeletal muscle cell consists of many consecutive cytoplasmic segments or nuclear domains, each of which is controlled by a nucleus (myonucleus) residing in that part of the myofiber [44]. If an atrophic muscle cell shrinks in cell volume but does not lose nuclei, the density of myonucleus in the atrophic myofiber is expected to increase.…”

Section: Other Causes Of Apoptosis Of Skeletal Muscle Cells In Musclementioning

confidence: 99%

“…The condensed nuclei could be identified in seemingly viable myotubes, as indicated by their capacity to exclude propidium iodide, which suggests the possibility that nuclei within a myotube may independently undergo apoptotic DNA changes at different times. It also suggests that the structure and function of the cytoplasmic segment (called nuclear domain [44]) controlled by the apoptotic nucleus, but not the entire myotube, may be altered or removed in an unsynchronized manner. When apoptosis of the entire myotube is complete, the domains that previously underwent apoptosis may begin to display secondary necrotic changes, thereby masking the ongoing apoptotic process (Fig.…”

Section: Apoptosis Of Multinucleated Skeletal Muscle Cells: In Vitro mentioning

confidence: 99%

Apoptosis of skeletal muscle cells and the pathogenesis of Myositis: A perspective

Liu

Ahearn

2001

Curr Rheumatol Rep

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Apoptosis is a genetically controlled form of cell death that occurs in many biologic processes including embryogenesis, immune cell development, and maintenance of peripheral immune tolerance. Recent studies have yielded evidence suggesting that apoptosis of parenchymal cells may play a role in providing self-antigens to initiate autoimmune reactions. Skeletal muscle cells are fully differentiated and multinucleated. Apoptosis has been described in developing myoblasts and, recently, in mature myotubes. However, the involvement of apoptosis in skeletal muscle pathologies is unclear. This article reviews the available data concerning the occurrence of skeletal muscle cell apoptosis in selected muscle diseases. It also discusses the potential role of muscle cell apoptosis in the development of autoimmune diseases such as idiopathic inflammatory myopathies.

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Studies on isolated human skeletal muscle fibersIncluding a proposed pattern of nuclear distribution and a concept of nuclear territories

Cited by 44 publications

References 7 publications

Cellular adaptation of the trapezius muscle in strength-trained athletes

Cellular adaptation of the trapezius muscle in strength-trained athletes

Myonuclear loss in atrophied soleus muscle fibers

Apoptosis of skeletal muscle cells and the pathogenesis of Myositis: A perspective

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