Studies on isolation, characterization of fucoidan from brown algae Turbinaria decurrens and evaluation of it's in vivo and in vitro anti-inflammatory activities

Manikandan, R.; Duraisamy, Parimalanandhini; Mahalakshmi, Krishnan; Balakrishnan, M.; Muthuvel, A.; Janarthanan, Sundaram; Palanisamy, Subramanian; You, SangGuan; Prabhu, Nagesh

doi:10.1016/j.ijbiomac.2020.05.152

Cited by 59 publications

(36 citation statements)

References 59 publications

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“…FTIR analysis against commercial fucoidan explained F4 fraction well aligned with commercial sample. Abundant fucose content via monosugar analysis as well conveyed its potential [36][37][38][39]. Thus, F4 was selected for subsequent experiments.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction

et al. 2020

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This study involves enzymatic extraction of fucoidan from Sargassum swartzii and further purification via ion-exchange chromatography. The chemical and molecular characteristics of isolated fucoidan is evaluated concerning its anti-inflammatory potential in RAW 264.7 macrophages under LPS induced conditions. Structural properties of fucoidan were assessed via FTIR and NMR spectroscopy. NO production stimulated by LPS was significantly declined by fucoidan. This was witnessed to be achieved via fucoidan acting on mediators such as iNOS and COX-2 including pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), with dose dependent down-regulation. Further, the effect is exhibited by the suppression of TLR mediated MyD88, IKK complex, ultimately hindering NF-κB and MAPK activation, proposing its therapeutic applications in inflammation related disorders. The research findings provide an insight in relation to the sustainable utilization of fucoidan from marine brown algae S. swartzii as a potent anti-inflammatory agent in the nutritional, pharmaceutical, and cosmeceutical sectors.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction

et al. 2020

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“…Ascophyllum nodosum fucoidan is highly branched with Fuc:Xyl:Gal ratio relatively 10:1:1 and traces of glucose and mannose, and it is reported to increase the production of IL-6, IL-8, and TNF-α from neutrophils [ 27 ]. Turbinaria decurrens polysaccharide with ratio Fuc:Gal:Xyl:Man:Rha = 6.0:1.3:1.1:1.0:0.6 reduced the expression of genes of COX-2, IL-1β, and the NF-κB signaling pathway [ 28 ]. The presence of carbohydrate receptors on dendritic cells provides an explanation for the important role of fucoidan monosaccharide content on its biological activity.…”

Section: Structure and Structure—activity Relationship Of Fucoidanmentioning

confidence: 99%

“…Manikandan et al [ 28 ] reported well-defined anti-inflammatory effect of fucoidan derived from Turbinaria decurrens on formalin-induced paw edema in mice. The sulfated polysaccharide reduced the expression of genes of COX-2, IL-1β, and the NF-κB signaling pathway.…”

Section: Anti-inflammatory Activity Of Fucoidan: Evidence From In mentioning

confidence: 99%

Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review

et al. 2020

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Inflammation is the initial response of the immune system to potentially harmful stimuli (e.g., injury, stress, and infections). The process involves activation of macrophages and neutrophils, which produce mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), pro-inflammatory and anti-inflammatory cytokines. The pro-inflammatory cytokines interleukin-1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) are considered as biomarkers of inflammation. Even though it occurs as a physiological defense mechanism, its involvement in the pathogenesis of various diseases is reported. Rheumatoid arthritis, inflammatory bowel disease, Alzheimer’s disease, and cardiovascular diseases are only a part of the diseases, in which pathogenesis the chronic inflammation is involved. Fucoidans are complex polysaccharides from brown seaweeds and some marine invertebrates, composed mainly of L-fucose and sulfate ester groups and minor amounts of neutral monosaccharides and uronic acids. Algae-derived fucoidans are studied intensively during the last years regarding their multiple biological activities and possible therapeutic potential. However, the source, species, molecular weight, composition, and structure of the polysaccharides, as well as the route of administration of fucoidans, could be crucial for their effects. Fucoidan is reported to act on different stages of the inflammatory process: (i) blocking of lymphocyte adhesion and invasion, (ii) inhibition of multiple enzymes, and (iii) induction of apoptosis. In this review, we focused on the immunemodulating and anti-inflammatory effects of fucoidans derived from macroalgae and the models used for their evaluation. Additional insights on the molecular structure of the compound are included.

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“…Meanwhile, mice could endure a repeated dosage of 10 mg/kg of fucoidan, and the drug revealed remarkable antitumor (inhibited tumor growth by 33%) and antimetastatic activities (29% reduction) [ 24 ]. Intraperitoneal injection and/or administration of fucoidan through food, gavages, subcutaneous injection, and intravenous injection have also been thoroughly researched [ 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles

et al. 2021

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Several types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage. The synergistic effect of fucoidan with existing anticancer drugs has prompted researchers to explore its therapeutic potential. This review compiles the mechanisms through which fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs. The obstacles involved in developing fucoidan as an anticancer agent are also discussed in this review.

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Studies on isolation, characterization of fucoidan from brown algae Turbinaria decurrens and evaluation of it's in vivo and in vitro anti-inflammatory activities

Cited by 59 publications

References 59 publications

Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction

Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction

Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review

The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles

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