Studies on Lymphogranuloma Venereum

Rake, Geoffrey; Jones, Helen

doi:10.1084/jem.75.3.323

Cited by 44 publications

(6 citation statements)

References 13 publications

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“…to 50 per cent. lethal dose (LD50) for chick Jones, 1942) which has a laboratory history of 30 embryos. Low dilutions of infected yolk sac were years.…”

Section: Sn Resultsmentioning

confidence: 99%

Study of Chlamydiae in patients with lymphogranuloma venereum and urethritis attending a veneral diseases clinic.

Philip¹,

Hill²,

Greaves³

et al. 1971

Sexually Transmitted Infections

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“…to 50 per cent. lethal dose (LD50) for chick Jones, 1942) which has a laboratory history of 30 embryos. Low dilutions of infected yolk sac were years.…”

Section: Sn Resultsmentioning

confidence: 99%

Study of Chlamydiae in patients with lymphogranuloma venereum and urethritis attending a veneral diseases clinic.

Philip¹,

Hill²,

Greaves³

et al. 1971

Sexually Transmitted Infections

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“…The earliest cultivation of chlamydiae, other than via animal passage, involved cultivation in embryonated eggs (Burnet & Rountree, ; Rake et al ., ; Rake & Jones, ) and facilitated the first investigations of chlamydial physiology.…”

Section: The Study Of Chlamydial Metabolism – a Historical Perspectivementioning

confidence: 99%

Chlamydial metabolism revisited: interspecies metabolic variability and developmental stage-specific physiologic activities

Omsland¹,

Sixt²,

et al. 2014

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Chlamydiae are a group of obligate intracellular bacteria comprising important human and animal pathogens as well as symbionts of ubiquitous protists. They are characterized by a developmental cycle including two main morphologically and physiologically distinct stages, the replicating reticulate body and the infectious non-dividing elementary body. In this review we reconstruct the history of studies that have led to our current perception of chlamydial physiology, focusing on their energy and central carbon metabolism. We then compare the metabolic capabilities of pathogenic and environmental chlamydiae highlighting interspecies variability among the metabolically more flexible environmental strains. We discuss recent findings suggesting that chlamydiae may not live as energy parasites throughout the developmental cycle and that elementary bodies are not metabolically inert but exhibit metabolic activity under appropriate axenic conditions. The observed host-free metabolic activity of elementary bodies may reflect adequate recapitulation of the intracellular environment, but there is evidence that this activity is biologically relevant and required for extracellular survival and maintenance of infectivity. The recent discoveries call for a reconsideration of chlamydial metabolism and future in-depth analyses to better understand how species- and stage-specific differences in chlamydial physiology may affect virulence, tissue tropism, and host adaptation.

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“…) Numerous bodies of similar appearance also were seen in impression films of lungs from infected mice. Individual bodies markedly resembled the elementary bodies of the psittacoid group of organisms (Chlamydozoaceae), but only occasionally were they seen in plaques or vesicles described as part of the developmental cycle of this group (7,8). Clusters of elementary bodies were seen best in films from allantoic fluid, although examination of films of lungs from infected mice occasionally revealed such arrangements of elementary bodies.…”

Section: Characteristics Of the Agentmentioning

confidence: 96%

A New Member of the Psittacosis-Lymphogranuloma Group of Viruses That Causes Infection in Calves

York

Baker

1951

Journal of Experimental Medicine

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From portions of intestine and feces of apparently normal calves, a virus that produces elementary bodies was procured in guinea pigs and in embryonated eggs. Morphologically and tinctorially this virus closely resembled members of the psittacosis-lymphogranuloma group of viruses and it shared a common antigen or antigens with them. Comparison of serological, pathogenic, and other properties indicated that this virus from calves is a new member of the psittacosis-lymphogranuloma group and in keeping with classification practices it is provisionally named Miyagawanella bovis. Miyagawanella bovis when fed to experimental calves established an infection in the intestinal tract that resembled the inapparent infection seen in natural cases but failed to produce evident disease. Ability of the virus to infect experimental animals by feeding, and its presence in feces of infected animals indicate its natural mode of spread. This method of dissemination and persistence of virus for long periods of time in infected animals suggested the virus should be widespread and more than 60 per cent of the calves in the vicinity of lthaca were found to be infected.

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Studies on Lymphogranuloma Venereum

Cited by 44 publications

References 13 publications

Study of Chlamydiae in patients with lymphogranuloma venereum and urethritis attending a veneral diseases clinic.

Study of Chlamydiae in patients with lymphogranuloma venereum and urethritis attending a veneral diseases clinic.

Chlamydial metabolism revisited: interspecies metabolic variability and developmental stage-specific physiologic activities

A New Member of the Psittacosis-Lymphogranuloma Group of Viruses That Causes Infection in Calves

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