1963
DOI: 10.1172/jci104757
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Studies on Lysosomes. Ii. The Effect of Cortisone on the Release of Acid Hydrolases From a Large Granule Fraction of Rabbit Liver Induced by an Excess of Vitamin A*

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Cited by 222 publications
(82 citation statements)
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“…The methods used in these experiments are the techniques commonly employed to study the effects of steroid hormones on lysosomal membranes (1,2,8,15,16 (17,18) have confirmed the stabilization hypothesis. Either no effect or mild stabilization has been noted with anti-inflammatory steroids, depending upon experimental conditions.…”
Section: Discussionmentioning
confidence: 67%
See 1 more Smart Citation
“…The methods used in these experiments are the techniques commonly employed to study the effects of steroid hormones on lysosomal membranes (1,2,8,15,16 (17,18) have confirmed the stabilization hypothesis. Either no effect or mild stabilization has been noted with anti-inflammatory steroids, depending upon experimental conditions.…”
Section: Discussionmentioning
confidence: 67%
“…Early studies by de Duve, Wattiaux, and Wibo (1) and by Weissmann and Thomas (2) showed that hydrocortisone retarded the release of acid hydrolases from isolated lysosomes. Since the contents of these subcellular organelles can induce inflammation, inhibition of their release would modify and diminish the inflammatory process (3).…”
Section: Introductionmentioning
confidence: 99%
“…Glucocorticoids may act by raising cyclic adenosine monophosphate (cyclic AMP) levels in mast cells, and we have previously shown that drugs which increase cyclic AMP suppress evoked histamine release from human skin (Yamamoto et al, 1973). Alternatively, corticosteroids may owe their inhibitory action on histamine release to their well-recognised ability to 'stabilise' intracellular organelle membranes including lysosomal membranes (Weissman & Thomas, 1963).…”
Section: Skin Histamine Contentmentioning
confidence: 99%
“…A wide range of steroids can be incorporated into natural and artificial lipid membranes (44,45); however, there does not appear to be a constant relationship between the ability of a steroid to do so and the structural features of the steroid molecule. The effect of steroids on membranes has been observed most vividly in their ability to stabilize or labilize artificial lipid membrane vesicles (46,47). In addition, some steroid hormones bind to the membrane proteins of red cells and this appears to underlie the effect of progesterone on the storage of human red cells (48).…”
Section: ±34mentioning
confidence: 99%