Studies on Magnesium Deficiency in Animals

Kruse, H. D.; Orent, Elsa R.; McCollum, E. V.

doi:10.1111/j.1753-4887.1979.tb06654.x

Cited by 3 publications

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“…This finding is similar to Smith et al 1958, 12 Pradhan et al 1964 10 and Sharma et al 1990. 11 In this serum potassium level was mean 5.1 mEq/L and serum calcium level was mean 9.37 mEq/L, so there was a positive correlation between serum potassium and serum magnesium level and negative correlation between serum magnesium and serum calcium level. These findings are supported by work done by Smith and Hammarsten 1959.…”

Section: Discussionmentioning

confidence: 69%

“…There are four major cations in the body namely sodium, potassium, calcium and magnesium; first three cations have been extensively studied but studies concerning magnesium metabolism have lagged in words of Peter and Vanslyke [1931] 9 ; so far no clinical significance has been attached to changes in magnesium metabolism due to the fact that Meltzer and Aner [1905] 8 demonstrated that raising the blood magnesium gives rise to coma and that Kruse et al [1932] 6 produced a form of tetany by inducing magnesium deficiency. It is possible that magnesium imbalance may be playing a greater role in clinical medicine than has been suspected heretofore.…”

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Assessment of Serum Magnesium Level in Chronic Renal Failure Patients and Its Clinical Significance and Correlation With Sodium, Potassium and Calcium

Ghritlahare¹,

Baranwal²

2016

jemds

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BACKGROUNDElectrolyte metabolism and its pathological alteration in relation to clinical features is subject of modern interest. There are four major cations in the body namely sodium, potassium, calcium and magnesium; first three cations have been extensively studied but studies concerning magnesium metabolism have lagged in words of Peter and Vanslyke [1931] 9 ; so far no clinical significance has been attached to changes in magnesium metabolism due to the fact that Meltzer and Aner [1905] 8 demonstrated that raising the blood magnesium gives rise to coma and that Kruse et al [1932] 6 produced a form of tetany by inducing magnesium deficiency. It is possible that magnesium imbalance may be playing a greater role in clinical medicine than has been suspected heretofore. There are conflicting report in literature concerning serum magnesium in chronic renal diseases, Huschfelder and Haury [1934], Marti et al [1952] and Boutwell [1961] found hypomagnesaemia, while Predhan et al [1961] and numerous others works found definite hypermagnesaemia in chronic renal disease. Pathophysiology of certain symptoms in uraemia remains a mystery. It is generally regarded that end products of metabolism accumulate lead to depression of central nervous system. If in cases of renal diseases without uraemia, when magnesium is given to the patient, depression of central nervous system is produced, Hirschfelder 1934, 4 which suggest that increase in serum magnesium may explain the nervous depression in uraemia patients. Engbaek [1952] and Cantarow [1959] stated that rise in serum magnesium is associated with the depression of central nervous system. These workers and others who found hypermagnesaemia in chronic renal disease found relationship with central nervous system depression in renal uraemia. The aims of this study are, 1. To find out the co-relationship of serum magnesium and blood urea in patients suffering from various types of kidney diseases. 2. To correlate the serum magnesium level with the depression of central nervous system if possible. 3. To find out the prognostic significance of serum magnesium level in cases wherever possible. 4. To find out the co-relationship to serum magnesium and serum potassium, serum calcium and serum sodium. MATERIALS AND METHODSThe present study comprised of 35 cases of chronic renal failure, 20 healthy control cases.Criteria for Selection of Cases -Diagnosis of chronic renal failure was established by measuring raised blood urea, nitrogen (BUN) and serum creatinine with clinical sign and symptoms of renal failure. Out of this 35 cases, 8 patients underwent haemodialysis procedures and followed the patients.Method for Estimation of Serum Electrolyte and Blood Urea and Serum Creatinine and other Investigations-1. Serum magnesium estimation was done by modified titan -yellow method as cited by Hawk et al. 2. Serum sodium and serum potassium estimation was done by flame photometry using E.E.L. Flame Photometry. Normal value for serum sodium -Range 137 -148 mEq/L and for Serum...

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Section: Discussionmentioning

confidence: 69%

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confidence: 99%

Assessment of Serum Magnesium Level in Chronic Renal Failure Patients and Its Clinical Significance and Correlation With Sodium, Potassium and Calcium

Ghritlahare¹,

Baranwal²

2016

jemds

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Magnesium bei Hund und Katze – physiologische Aspekte, Messung und Störungen im Magnesiumhaushalt

Schulz¹,

Güssow²,

Bauer³

et al. 2018

Tierarztl Prax Ausg K

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ZusammenfassungMagnesium ist nach Kalium das intrazelluläre Kation, das in höchster Konzentration im Körper vorkommt. Es spielt eine fundamentale Rolle in nahezu jedem metabolischen Prozess und ist wichtig für die Knochenmineralisierung, die Kontraktion und Relaxation des Muskels sowie die neuronale Erregungsübertragung. Aufgrund seiner Relevanz in der Intensivmedizin kam es in den letzten Jahren zu einem deutlichen Wissenszuwachs hinsichtlich des Verständnisses über die Funktionen von Magnesium im Körper, die Probleme, die zur Störung der Magnesiumhomöostase führen, und labordiagnostische Limitationen. Abweichungen der Serumkonzentration von Magnesium stellen eine der häufigsten Elektrolytstörungen dar und können zu lebensbedrohlichen Zuständen führen. Die _tamen_ Informationen bezüglich der Rolle von Magnesium _tamen neben der humanmedizinischen Literatur vor allem aus der Rindermedizin. In den letzten Jahren beschäftigten sich einige wenige Studien auch mit der Bedeutung dieses Elektrolyts bei Hund und Katze.

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Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

et al. 2022

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A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of vitamin E have been unraveled in both cell and animal models, including antioxidant and anti-inflammatory properties, as well as regulatory activities on cell signaling and gene expression. However, the bioavailability and physiological functions of vitamin E have been considerably shown to depend on lifestyle, genetic factors, and individual health conditions. Another important facet that has been considered less so far is the endogenous interaction with other nutrients. Accumulating evidence indicates that the interaction between vitamin E and other nutrients, especially those that are enriched by supplementation in humans, may explain at least some of the discrepancies observed in clinical trials. Meanwhile, increasing evidence suggests that the different forms of vitamin E metabolites and derivates also exhibit physiological activities, which are more potent and mediated via different pathways compared to the respective vitamin E precursors. In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.

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Studies on Magnesium Deficiency in Animals

Cited by 3 publications

References 0 publications

Assessment of Serum Magnesium Level in Chronic Renal Failure Patients and Its Clinical Significance and Correlation With Sodium, Potassium and Calcium

Assessment of Serum Magnesium Level in Chronic Renal Failure Patients and Its Clinical Significance and Correlation With Sodium, Potassium and Calcium

Magnesium bei Hund und Katze – physiologische Aspekte, Messung und Störungen im Magnesiumhaushalt

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

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