STUDIES ON MIMUSOPS spp.

Misra, G.; Sk, Nigam; Cr, Mitra

doi:10.1055/s-0028-1097983

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Auto-oxidation of thiols can generate superoxide [42], which can promote oxidation of LDL in the presence of transi- Thiols (100 pM) were added to Hams F10 medium, formulated without cystine, supplemented with or without FeSO4 (6/.tM) and EDTA (10 pM) at 37°C for 6-8 h. The free thiol concentration was measured at intervals of one hour using DTNB (0.I mM, final concentration) as described in section 2; values are means + ranges of two independent experiments. [35,44].…”

Section: Discussionmentioning

confidence: 99%

Structural requirements for oxidation of low‐density lipoprotein by thiols

Wood¹,

Graham²

1995

FEBS Letters

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Oxidation of low-density iipoprotein (LDL) by macrophages, endothelial cells and smooth muscle cells, may be mediated by production of free thiols in the presence of transition metals. We examined the structural requirements, within a series of cysteinyl derivatives, for oxidation of thiols and of LDL in Hams FI0 medium. The primary mechanism by which such thiols mediate oxidation of LDL is largely independent of superoxide production, but strongly correlated with the susceptibility of each thiol to iron-catalysed auto-oxidation. These effects are compared and contrasted with thiol-dependent oxidation of LDL by stimulated human monocytes and macrophages.

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Section: Discussionmentioning

confidence: 99%

Structural requirements for oxidation of low‐density lipoprotein by thiols

Wood¹,

Graham²

1995

FEBS Letters

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“…Aunque para la especie en estudio no existen antecedentes de su composición, para otras espe-cies del género se han informado ácidos grasos como oleico, palmítico y esteárico (Misra y Mitra, 1968;Misra et al, 1974;Fayek et al, 2012;Sathish Kumar et al, 2015;Chivandi et al, 2016). De igual forma, se ha informado la presencia de acetato de β-amirina, acetato de α-amirina y ácido ursólico por Misra y Mitra (1966a, b;1968), Misra et al (1974) y Fayek et al (2012). Sin embargo, para la presencia del escualeno en la especie, no se encontró información en la literatura.…”

Section: Febrero Agostounclassified

Composición química, capacidad antioxidante y actividad antiinflamatoria de los frutos de Mimusops coriacea (A.DC) Mig (Sapotaceae) que crece en Ecuador

Pesantes¹,

Gaitén²,

Chóez-Guaranda³

et al. 2021

J Pharm Pharmacogn Res

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Context: Mimusops coriacea (Sapotaceae) is traditionally used to treat inflammation of the urethra, cystitis, diarrhea, and dysentery, among others. In Ecuador it is used as an analgesic and anti-inflammatory, however the phytochemical and pharmacological information is scarce. Aims: To evaluate the chemical composition, antioxidant capacity and anti-inflammatory activity of the M. coriacea fruits in two stages of ripening. Methods: An extraction with hexane by Soxhlet of the oils of the seeds of green and mature fruits was carried out. Saponifiable and unsaponifiable fractions were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). Hydroalcoholic extracts were obtained by maceration from the green and ripe whole fruits and were tested by Liquid Chromatography-Mass Spectrometry (LC-MS). Antioxidant capacity by FRAP, DPPH and ABTS and anti-inflammatory activity using the plantar edema model by carrageenan were evaluated. Results: In the saponifiable fractions, four fatty acids were identified (majority 9-octadecenoic acid) and in the unsaponifiable ones four compounds were assigned to green fruits and nine to mature fruits, the majority being squalene and urs-12-en-24-oico, 3-oxo-methyl ester, respectively. By LC-MS 31 compounds were identified, associated with phenolic compounds and triterpenic saponins. The extracts showed Fe3+ reducing capacity and antiradical activity, the green fruit extract was the most active (IC50s = 4.99 μg/mL and 246.80 μg/mL, DPPH and ABTS, respectively). The anti-inflammatory activity of the extracts was demonstrated with inhibition percentages greater than 50% by using indomethacin as reference drug. Conclusions: The results provide the first findings of the phytochemical and bioactive potential of the M. coriacea species that grows in Ecuador.

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“…Summary of the related literature have been discussed in Table 3. Madhak et al, (2013) Misra et al, (1974) show the presence of the fatty acid esters of common triterpene alcohols from fruit pulps of M. hexandra.…”

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confidence: 99%

Traditional Uses, Phytochemistry and Pharmacology of Mimusops hexandra Roxbs

Mishra¹

2014

Adv. pharm. ethnomed.

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STUDIES ON MIMUSOPS spp.

Cited by 9 publications

References 5 publications

Structural requirements for oxidation of low‐density lipoprotein by thiols

Structural requirements for oxidation of low‐density lipoprotein by thiols

Composición química, capacidad antioxidante y actividad antiinflamatoria de los frutos de Mimusops coriacea (A.DC) Mig (Sapotaceae) que crece en Ecuador

Traditional Uses, Phytochemistry and Pharmacology of Mimusops hexandra Roxbs

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