Studies on mitochondria:

A close mutual relationship between the processes of oxidation and oxidative phosphoryiation and the maintenance of the structural integrity of mitochondria (1) has been proposed. By use of the high energy phosphate bonds generated during the metabolism, the mitochondria contribute for some time to their self preservation. It is, however, very probable that other cellular structures, which lack the means of elaborating ~-~P,~ also utilize the energy provided by the mitochondrial metabolism for their structure and function. There are, however, no available studies which provide information that the mitochondria supply N p directly to other structures in order to maintain them. The present studies deal with the occurrence of such a relationship in skeletal muscle between the cytochondria (2) and the myofibrils.Since the pioneer physiological studies of Ranvier (3) and BonhSffer (4), and the later metabolic work of Battelli and Stern (5), it has been realized that the difference in structure of muscles is associated with a difference in function and oxidative capacity. Stare and Baumann (6) later catalogued several of the outstanding variations among muscles and established the high

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“…In the studies on purified particles, care was taken to maintain iso-osemotic conditions in the flasks as in earlier investigations (13).…”

Section: Manometricmentioning

confidence: 99%

“…At the beginning of the manometric experiment a sample of the suspension was examined by phase contrast and a differential count made as described previonsly (13). At intervals of 15 to 20 minutes flasks were removed and the contents similarly studied.…”

Section: Manometricmentioning

confidence: 99%

The Relationship Between Cytochondria and Myofibrils in Pigeon Skeletal Muscle

Harman

Osborne

1953

Journal of Experimental Medicine

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“…A considerable part o'f the experimental data testified that under conditions favouring oxidative phosphorylation, mitochondrial swelling and related processes are slowed down [1][2][3][4][5][6][7][8]. It was also suggested that the level of endogenous ATP is of prime importance for preservation of the phosphorylating capacity of mitochondria and inhibition of swelling [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Degradation of mitochondrial respiratory system of Saccharomyces cerevisiae, induced by respiratory inhibitors, uncouplers and anaerobiosis

1970

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“…Such studies have utilized both direct visual observations including phase contrast microscopy (1)(2)(3)(4)(5) as well as photometric observations of the light-scattering properties of mitochondrial suspensions (3,(5)(6)(7)(8)(9)(10)(11). With few exceptions (12,13) the photometric observations have been confined entirely to studies of the optical density of mitochondrial suspensions under different conditions.…”

mentioning

confidence: 99%

Angular Light-Scattering Studies on Isolated Mitochondria

Gotterer¹,

Thompson²,

Lehninger³

1961

The Journal of Cell Biology

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Angular light-scattering studies have been carried out on suspensions of isolated rat liver mitochondria. The angular scatter pattern has a large forward component, typical of large particles. Changes in dissymmetry and in the intensity of light scattered at 90 ° have been correlated with changes in optical density during the course of mitochondrial swelling and contraction. Such changes can be measured at mitochondrial concentrations much below those required for optical density measurements. Changes in mitochondrial geometry caused by factors "leaking" from mitochondria, not detectable by optical density measurements, have been demonstrated by measuring changes in dissymmetry. Angular light-scattering measurements therefore offer the advantages of increased sensitivity and of added indices of changes in mitochondrial conformation.

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Studies on mitochondria:

Cited by 95 publications

References 34 publications

The Relationship Between Cytochondria and Myofibrils in Pigeon Skeletal Muscle

The Relationship Between Cytochondria and Myofibrils in Pigeon Skeletal Muscle

Degradation of mitochondrial respiratory system of Saccharomyces cerevisiae, induced by respiratory inhibitors, uncouplers and anaerobiosis

Angular Light-Scattering Studies on Isolated Mitochondria

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