Studies on Mixed Infections. I. Brucellosis and Q Fever

Mika, Leonard A.; Goodlow, Robert J.; Victor, Joseph; Braun, Werner

doi:10.3181/00379727-87-21424

Cited by 13 publications

(7 citation statements)

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“…PuMnger (5) and Nyka (6) demonstrated in the guinea pig, for example, a nonspecific immune response caused by tubercle bacilli which interfered with the course of a Brucella specific infection. Mika, Goodlow, Victor, and Braun (7) showed that in the guinea pig an infection by Brucella species effected a non-specific resistance in the host to a super-infection with Coxiella burnetii. A quantitative study by Henderson, Lancaster, Packman, and Peacock (8) utilizing Brucella suis as the primary invader, M. tuberculosis as the secondary invader, and the respiratory route of infec-tion, demonstrated that when the primary infection induced a generalized lymphatic response there was also produced a non-specific resistance against secondary infections with organisms whose normal route of invasion is through the lymphatic system.…”

Section: Resistance Of Monocytes From Immunized Rabbits To Homologousmentioning

confidence: 99%

Cross-Immunity Between Brucella Melitensis and Mycobacterium Tuberculosis

Elberg

Schneider

Fong

1957

The Journal of Experimental Medicine

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Earlier studies (1, 2) on the tubercle bacillus-monocyte relationship were directed towards an understanding first of procedural problems, a solution to which was essential if the "natural history" (in a tissue culture type of environment) of the fate of parasitized monocytes was to be recorded. Preliminary trypsinization of rabbit monocytes and employment of 40 per cent rabbit serum in Tyrode's solution created conditions in which uninfected suspensions of monocytes exhibited little change in cell numbers over a 72 hour period in the Mackaness type of culture chamber. It was then possible to demonstrate clearly that monocytes derived from BCG-vaccinated rabbits bathed in variously derived antisera constituted a system highly immune to the normally destructive action of the virulent tubercle bacilli and further, that whereas the action of the antiserum was relatively non-specific, the resistance evidenced by the monocytes from vaccinated rabbits was of a greater degree of specificity.The present paper describes the cross-immunity conferred on monocytes by immunization of the host against infection either by Mycobacteriurn tuberculosis or Brucella melitensis. Data are presented which describe the ability of the monocytes from specifically immunized and normal animals to handle ingested virulent Brucetla, and finally, observations are described which show that absorption of the agglutinating antibody does not diminish the enhancing action of the anti-Brucella rabbit serum. Materials and MethodsMonocytes.--An adult normal rabbit or one which had been vaccinated with the Brucdla vaccine (3) or with BCG was used as a source of normal or immune monocytes.

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Section: Resistance Of Monocytes From Immunized Rabbits To Homologousmentioning

confidence: 99%

Cross-Immunity Between Brucella Melitensis and Mycobacterium Tuberculosis

Elberg

Schneider

Fong

1957

The Journal of Experimental Medicine

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“…Previous studies in this series (Mika et al, 1954;Victor et al, 1955) have shown that guinea pigs infected with Brucella suis were refractory to the lethal effect of a subsequent infection with Coxiella burnetii. The data indicated that an infection with B. suis had to be established in the host animal for a suitable length of time before interference between the primary brucellosis and the secondary rickettsial infection could be demonstrated.…”

mentioning

confidence: 66%

STUDIES ON MIXED INFECTIONS IV.Brucella suisandCoxiella burnetii

Pirsch

Mika

1959

J Bacteriol

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“…Previous reports have referred to the activity of C. burnetii against Brucella suis in vivo (32) and to the in vitro suppression of Listeria monocytogenes by supernatants from macrophages Radiation resistance ofprotection against P. vinckei petteri by pretreatment with Coxiella extract. Symbols: A, 200 ,ul of extract given 4 weeks earlier and 900 rads given on day -1; U, extract alone; 0, 900 rads alone; 0, controls.…”

Section: Discussionmentioning

confidence: 99%

“…Because Coxiella burnetii also shares these characteristics (26,27,32,43), I decided to test whether the similarity extended to protection against blood parasites as well. The results demonstrate that a commercially available extract of C. burnetii protects mice against B. microti, Babesia rodhaini, and P. vinckei petteri.…”

mentioning

confidence: 99%

Resistance to Babesia spp. and Plasmodium sp. in mice pretreated with an extract of Coxiella burnetii

Clark¹

1979

Infect Immun

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Mice injected intravenously with a commercially available extract of Coxiella burnetii prepared for use as the antigen in the complement fixation diagnostic test for Q fever were subsequently resistant to infection with Babesia microti, Babesia rodhaini, and Plasmodium vinckei petteri. The parasites appeared to die inside circulating erythrocytes. Protection was unaffected by exposing the pretreated mice to 900 rads on the day before they were infected. To explain these findings, it is postulated that pretreatment with Coxiella extract protects by potentiating the interferon-inducing capacity of the challenge dose of protozoa, which perhaps leads to enhanced of natural killer cells. Tumor necrosis factor also warrants investigation.

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Studies on Mixed Infections. I. Brucellosis and Q Fever

Cited by 13 publications

References 0 publications

Cross-Immunity Between Brucella Melitensis and Mycobacterium Tuberculosis

Cross-Immunity Between Brucella Melitensis and Mycobacterium Tuberculosis

STUDIES ON MIXED INFECTIONS IV.Brucella suisandCoxiella burnetii

Resistance to Babesia spp. and Plasmodium sp. in mice pretreated with an extract of Coxiella burnetii

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