Studies on mutlispecific resistance of gastrointestinal nematodes to benzimidazoles on dairy-goat farms

Cabaret, Jacques; Baudet, H.M.; Devos, J.; Hubert, J; Cortet, Jacques; Sauvé, Christine

doi:10.1016/0304-4017(95)00786-2

Cited by 25 publications

(8 citation statements)

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“…In the Burgundy area in 1999 (F. Beugnet, personal communication, 2000), all the ten surveyed dairy goat farms showed benzimidazole resistant nematodes through the FECRT. In central France, on three dairy goat flocks, Cabaret et al (1995) also showed that benzimidazole resistance was multispecific and that resistant populations included mainly Trichostrongylus colubriformis (50 to 95% of the resistant populations) followed by Teladorsagia circumcincta, H. contortus and O. venulosum.…”

Section: Discussionmentioning

confidence: 96%

“…The majority of these surveys were conducted on fibre goats, the resistance involved mainly benzimidazole drugs and directed against several species. In France, goats are bred exclusively for milk production and numerous cases of anthelmintic resistance (benzimidazoles) have been reported since 1985 (Kerboeuf & Hubert, 1985;Hubert et al, 1991;Beugnet, 1992;Chartier & Pors, 1994;Cabaret et al, 1995). In contrast, prevalence surveys based on random sampling of farms remained limited to a single study conducted in western France, in which 15 out of 15 surveyed farms harboured benzimidazole resistant worms (Chartier et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of anthelmintic resistance in gastrointestinal nematodes of dairy goats under extensive management conditions in southwestern France

et al. 2001

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The occurrence of benzimidazole (BZ) and levamisole resistance was investigated in 18 randomly selected dairy goat herds located in southwestern France and characterized by extensive management. On each of the 18 farms, 45 adult goats were randomly allocated into three groups of 15 animals each: an untreated control group, a group that was orally administered fenbendazole (10 mg kg-1 body weight) and a group that received orally a levamisole drench (12 mg kg-1 body weight). Individual faecal egg counts and pooled larval cultures were done 10 days after anthelmintic treatment. Naive lambs were infected with larvae obtained from control and fenbendazole treated groups and were necropsied 35 days after infection for worm recovery. Faecal egg count reductions (FERC) were calculated for fenbendazole and levamisole and, when less than 95 per 100, were considered as indicative of anthelmintic resistance. An in vitro egg hatch test (EHT) was conducted with thiabendazole on eggs isolated from pooled faeces of fenbendazole treated goats in nine farms. Faecal egg count reductions indicated the occurrence of benzimidazole resistance in 15 out of 18 farms. Among these farms, nine had EHT values above 0.1 μg thiabendazole ml-1 confirming the benzimidazole resistance status. Levamisole resistance was detected in two farms through FECR. Based on necropsy results, the prevalence of benzimidazole resistance was higher in Trichostrongylus colubriformis, medium in Haemonchus contortus and lower in Teladorsagia circumcincta. In nine farms the benzimidazole resistance was monospecific whereas multispecific resistance was found in the six remaining farms. A negative relationship was found between FECR for fenbendazole and the average number of anthelmintic treatments given per year on the farm. Despite extensive management including a low number of treatments, the prevalence of benzimidazole resistance was very high suggesting that the repeated and sometimes exclusive use of benzimidazole drugs, even at low frequency, is probably the main cause in developing nematode resistance in dairy goat herds. The importance of other factors such as under-dosing or buying animals already carrying resistant nematodes are discussed.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Prevalence of anthelmintic resistance in gastrointestinal nematodes of dairy goats under extensive management conditions in southwestern France

et al. 2001

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“…Several occurrences of multiple anthelminthic resistances have been reported in goat flocks throughout the world, including resistance to the most recent macrocyclic lactones: USA (Mortensen et al 2003;Howell et al 2008), New Zealand (West et al 2004) and Ethiopia (Kumsa and Abebe 2009). In France, several cases of benzimidazole resistance have been reported in goats (Chartier and Pors 1994;Cabaret et al 1995;Chartier et al 1998 and. Suspicions of levamisole resistance are less common (Chartier and Pors 1994;Chartier et al 2001) but one case of double resistance to benzimidazole and levamisole has been recently confirmed in a dairy goat farm in the western part of the country (Paraud et al 2009b).…”

Section: Introductionmentioning

confidence: 91%

Absence of ivermectin resistance in a survey on dairy goat nematodes in France

Paraud

Pors

Rehby³

et al. 2010

Parasitol Res

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Anthelmintic resistance is very prevalent in ruminant strongyle populations, especially in goats. Several occurrences of multiple anthelminthic resistances have been reported in goat flocks throughout the world, including resistance to the most recent macrocyclic lactones. A faecal egg count reduction test was conducted to detect resistance to ivermectin in French goat flocks. Thirty goats per flock were randomly selected in 22 flocks and allocated into two groups of 15 animals: an untreated control group and an ivermectin-treated group (0.3 mg/kg BW per os). Individual faecal egg counts and pooled larval cultures were performed 16-17 days after anthelmintic treatment for control and treated groups. FECR's were calculated for treated group vs. control one and when <95/100, were considered as indicative of anthelmintic resistance. FECR results indicated the absence of ivermectin resistance in nematode populations from all the 22 goat farms. The nematode genera involved in control groups were of Teladorsagia/Trichostrongylus, Haemonchus and Oesophagostomum/Chabertia types.

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“…Resistance in goat GI nematodes to BZs is widespread (≥ 80% prevalence) in Denmark [11] and Slovakia [12]. BZ resistance has become a serious problem primarily in France; all goat herds investigated were affected in some regions [13,14], and the problem was not less pronounced in farms under extensive management [15]. The frequency of BZ resistance in goats in other countries such as Norway has been determined to be low [16].…”

Section: Introductionmentioning

confidence: 99%

Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms

Vadlejch

Kyriánová

Várady

et al. 2020

Preprint

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Background: Strongylid nematode infections may negatively affect both animal health and welfare, with deleterious consequences for livestock productivity. Many farmers in recent decades have relied on anthelmintics as the sole strategy of control, but the intensive use of these chemotherapeutics has led to the development of anthelmintic resistance (AR). Knowledge of both the efficacy of anthelmintics and factors promoting AR are essential to effectively control nematode infections, but no information on these topics for goats in the Czech Republic (CR) is available. This survey aimed to determine the occurrence of AR at Czech goat farms and to identify risk factors for the development of AR. A total of 24 herds of dairy goats across the CR were evaluated using in vitro tests for detecting AR, and a questionnaire survey was carried out to evaluate factors associated with AR.Results: Resistance against benzimidazoles was confirmed at 75% of the farms, and the level of resistance was high in 22% of the affected herds based on the egg hatch test. Ivermectin-resistant nematodes were detected in 54% of the herds using the larval development test; Teladorsagia/Trichostrongylus and Haemonchus were the predominant types of resistant larvae. More than half (62%) of the affected herds were evaluated as highly resistant to ivermectin. Almost half (46%) of the herds were resistant to both benzimidazoles and ivermectin. This report is the first on multiple AR in the CR. A univariate logistic regression analysis indicated that a high stocking rate and farmer inexperience were significantly associated with ivermectin and benzimidazole resistance, respectively.Conclusions: The results of our survey suggest that AR is widespread amongst herds of dairy goats in the CR, likely due to inappropriate practices of pasture and health management. Multiple AR may be an issue for expanding dairy-goat production in the CR in the near future unless both veterinary practitioners and farmers widely adopt strategies to prevent the development of AR.

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Studies on mutlispecific resistance of gastrointestinal nematodes to benzimidazoles on dairy-goat farms

Cited by 25 publications

References 8 publications

Prevalence of anthelmintic resistance in gastrointestinal nematodes of dairy goats under extensive management conditions in southwestern France

Prevalence of anthelmintic resistance in gastrointestinal nematodes of dairy goats under extensive management conditions in southwestern France

Absence of ivermectin resistance in a survey on dairy goat nematodes in France

Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms

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