Studies on Natural History of Multiple Sclerosis

Kurtzke, John F.; Beebe, Gilbert W.; Nagler, Benedict; Auth, Thomas L.; Kurland, Leonard T.; Nefzger, M. Dean

doi:10.1111/j.1600-0404.1968.tb05587.x

Cited by 70 publications

(41 citation statements)

References 7 publications

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“…So far my knowledge goes no study has yet been published on multiple sclerosis in Bangladesh. The present study disclosed that certain clinical features of multiple sclerosis patients are different from those of multiple sclerosis patients in western countries, but the age distribution in Bangladeshi multiple sclerosis patients were not significantly different from those of western and other Asian countries 24,25 .…”

Section: Discussioncontrasting

confidence: 53%

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Initial Neurologic Symptoms Among Bangladeshi Multiple Sclerosis Patients

Miah

Sheikh

Khan

et al. 1970

Bangla. J. Neuroscience

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Section: Discussioncontrasting

confidence: 53%

“…Five (20%) patients had optic neuritis alone, seven (28%) had optic nerve and brain involvement, four (16%) had optic nerve and spinal cord involvement. It was 43% in Japanese nationwide series, 14% in Israel, 43% in Brazil, 36% in Germany, 56% in Taiwan, 28% among UK army and 25% in the USA 24,30,[33][34][35] .…”

Section: Discussionmentioning

confidence: 99%

Initial Neurologic Symptoms Among Bangladeshi Multiple Sclerosis Patients

Miah

Sheikh

Khan

et al. 1970

Bangla. J. Neuroscience

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“…The EDSS mean score of 6.5 (SD±0.6) points 67% of the patients as dependent in walking and the OMDS mean score of 8 (SD±2.4) points it too. EDSS is currently the most used assessment instrument in clinical trials 9 . OMDS score of 5 indicates one hand support needed to walk and score of 9 indicates that the patient is unable to walk (crawls on hands and knees) 10 .…”

Section: Discussionmentioning

confidence: 99%

“…The EDSS score <6 corresponds to a patient who is able to walk with bilateral support. EDSS total score ranges from zero (normal) to 10 (complete incapacity) 9 . The OMDS score ≤6 indicates that the patient is able to walk 100 meters using an assistance device.…”

Section: Methodsmentioning

confidence: 99%

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Implications of HAM/TSP functional incapacity in the quality of life

Shublaq

Orsini

Puccioni-Sohler

2011

Arq. Neuro-Psiquiatr.

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Objective: To identify the functional status and quality of life of HAM/TSP patients. Method: We evaluated prospectively 30 HAM/TSP patients (20 females) seen in the Neuroinfection Clinic of the HUGG. The functional capacity was analyzed by the functional independence measure (FIM), the expanded disability status (EDSS) scale and the Osame's motor disability score (OMDS). The quality of life was assed by the Short-Form Health Survey 36 (SF-36) TM . Results: All patients need assistance device. The FIM, OMDS and EDSS scores classified 70%, 67% and 67% of the patients as dependent, respectively. The lowest scores of the SF-36 survey were found in the domains related to the physical health (D1, D2), role-emotional functioning (D7) and social functioning (D6). Conclusion: Our data suggest that the HAM/TSP physical impairment has an impact in the emotional and social issues, considering the limitation in the daily activities. Key words: HAM/TSP, myelopathy, functional capacity, quality of life.Implicações da incapacidade funcional na qualidade de vida de pacientes com HAM/TSP RESUMO Objetivo: Avaliar a capacidade funcional e sua interferência na qualidade de vida de pacientes com HAM/TSP. Método: Foram analisados prospectivamente 30 casos (20 mulheres) de HAM/TSP, atendidos no Ambulatório de Neuroinfecção do HUGG. As escalas para avaliação da capacidade funcional consistiram em: medida de independência funcional (FIM), escala de incapacidade expandida (EDSS) e pontuação da incapacidade motora de Osame (OMDS). A qualidade de vida foi analisada pelo Short-Form 36 Health Survey (SF-36) TM . Resultados: Todos os pacientes necessitavam de assistência para deambular. As escalas FIM, OMDS e EDDS classificaram 70%, 67% e 67% dos pacientes como dependentes, respectivamente. A avaliação pelo SF-36 demonstrou menores escores nos domínios físico (D1, D2), emocional (D7) e social (D6). Conclusão: Os achados sugerem que a limitação nas atividades diárias decorrentes do envolvimento físico comprometem aspectos emocionais e sociais na HAM/TSP. Palavras-chave: HAM/TSP, mielopatia, capacidade funcional, qualidade de vida.

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Studies on the Natural History of Multiple Sclerosis

Kurtzke¹

1970

Arch Neurol

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ESTIMATES of longevity after onset or diagnosis of multiple sclerosis (MS) have been highly variable, and few have been based on data arising out of a numerically large series collected near onset and followed for a lengthy period. Recent evidence has called into question the common concept that MS is generally progressive and usually fatal within five to 20 years.The US veteran population is an exceptional resource for the study of disease. It comprises an enumerable population, wel l \x=req-\ indexed at many points of medical interest, and with a potential for long-term follow-up study that is unparalleled in the United States. During World War II a large proportion of the entire population of young men served in the Armed Forces, where medical care was available without regard to prior residence or socioeconomic status. Vet-erans with service-connected disabilities have been eligible for later medical care under the auspices of the Veterans Administration (VA) again without regard to residence or economic status.For the study of MS, the veteran popula¬ tion has additional advantages. This diagno¬ sis made one ineligible for military service, so that cases discovered in service should be at or near clinical onset. Furthermore, whenever the diagnosis of MS was enter¬ tained in service, neurologic evaluation was unusually thorough as MS was also grounds for medical discharge. For these reasons we selected the World War II Army series for an extensive study14 of the natural history of MS.The present report is concerned with sur¬ vival to Jan 1, 1963, with particular atten¬ tion to the influence of our diagnostic review of cases, and of age at onset and diagnosis, upon the estimates of mortality over time.Other influences on survival will be consid¬ ered in a later paper. Materials and MethodsThe origin of the series, derivation of the study sample, and the diagnostic reviews, have been previously described.1 The initial series of 762 cases consists of all identifiable men with 90 or more days of service who received a final diagnosis of MS in an Army hospital during 1942 to 1951. Final study diagnoses for the 762 men in the series were established by our review of the clinical records. Two diagnostic reviews were made, and both involved independent apprais¬ als of each case by at least three neurologists (B.N., J.F.K., L.T.K., and T.L.A.) using essen-

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Studies on Natural History of Multiple Sclerosis

Cited by 70 publications

References 7 publications

Initial Neurologic Symptoms Among Bangladeshi Multiple Sclerosis Patients

Initial Neurologic Symptoms Among Bangladeshi Multiple Sclerosis Patients

Implications of HAM/TSP functional incapacity in the quality of life

Studies on the Natural History of Multiple Sclerosis

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