In this study have investigated the mass attenuation coefficient and air Kerma of some CT contrast agents and painkiller. The mass attenuation coefficient and air Kerma of Iotrolan, Iodixanol, Iohexol, Ioxilan, Ioversol, Iomeprol, Ketoprofen, Flurbiprofen, Etodolac, İbuprofen, Meloxicam, Diflofenac and Aspirin have been calculated by using WinXCom in the energy range from 1 keV to 1000 keV. The current study would be useful to develop new shielding materials in radiation application fields.