Studies on Ni(II), Cu(II) and Zn(II) complexes with 2-aminobenzamide and some bioactive imidazole enzyme constituents

Chemical Characterization and Biological Evaluation of New Cobalt(II) Complexes with Bioactive Ligands, 2-Picolinehydroxamic Acid and Reduced Schiff Base N-(2-Hydroxybenzyl)alanine, in Terms of DNA Binding and Antimicrobial Activity

“…The obtained value is more positive than those given for other heteroligand systems [9,40], most likely due to the presence of a phenol ring affecting the stability of the heteroligand complex. It appears that the stacking interaction occurring between the AlaSal aromatic ring, which is flexible, and the PicHA pyridine ring, which is rigidly attached to the metal ion in an equatorial position, results in the heteroligand complex demonstrating greater stability than the binary complex [CoL'H] + with one protonated molecule [41].…”

“…The parameter is more positive than the predicted values for octahedral geometries [9]. This indicates that the addition of protonated AlaSal as the third molecule allows higher stabilization of the heteroligand complex 3 than its primary analogs.…”

“…When looking for new drugs, a range of pharmacologically promising compounds should be evaluated, and this evaluation should include their chemical and biological properties. Heteroligand structures play an important role in biological processes [8][9][10][11], and model systems containing aromatic amines as the primary ligand and amino acid derivatives as the secondary ligand could be used to better understand the transport of metal ions and active substances through membranes and biochemical reactions catalyzed by metalloenzymes [12]. The aromatic properties improve the lipophilicity of the complexes [13], thus increasing the permeability through the cell wall [14].…”

Prediction of Stability Constants of Zinc(II) Complexes with 2-aminobenzamide and Amino Acids

“…= 0.04 and 0.06 for quadratic and linear function, respectively; N = 4). As the dependence of log β ZnLB on temperature in the range 300-330 K is linear, 17 we proposed the model for all four of the temperatures (N = 16) simply by including temperature into Eq. (7):…”

Co(III) and Cu(II) benzimidazole Schiff base complexes: Synthesis, Characterization and DNA binding and cleavage activity

“…The above results clearly indicate C4 cleaves DNA by a hydroxyl radical and prefers to bind DNA through the minor groove only. In general, metal complexes cleave CT-DNA oxidatively in the presence of H 2 O 2 as co-reactant by producing molecular oxygen, or peroxy derivatives or diffusible hydroxyl radicals via Fenton mechanism or Haber-Weiss mechanism 29 . In the UV region, the compounds represent two bands at 220 and 270 nm, which can be attributed to the π→π* transition of the benzimidazole Schiff base and 1, 10-phenanthroline moiety.…”