2002
DOI: 10.1248/cpb.50.1349
|View full text |Cite
|
Sign up to set email alerts
|

Studies on Non-Thiazolidinedione Antidiabetic Agents. 1. Discovery of Novel Oxyiminoacetic Acid Derivatives.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
11
0

Year Published

2003
2003
2013
2013

Publication Types

Select...
5
1
1

Relationship

1
6

Authors

Journals

citations
Cited by 18 publications
(11 citation statements)
references
References 42 publications
0
11
0
Order By: Relevance
“…Female KK-A y mice are used for evaluation of antiobesity and antidiabetic effects of compounds and extracts, [25][26][27] since body weight over 8 weeks old is higher in female than in male. For this reason, we used female KK-A y mice in this study.…”
Section: Discussionmentioning
confidence: 99%
“…Female KK-A y mice are used for evaluation of antiobesity and antidiabetic effects of compounds and extracts, [25][26][27] since body weight over 8 weeks old is higher in female than in male. For this reason, we used female KK-A y mice in this study.…”
Section: Discussionmentioning
confidence: 99%
“…Throughout the study, they were housed in metal mesh cages and fed a commercial diet CE-2 (Clea, Japan) and water ad libitum. They were divided into 16 groups (5 rats in each group) based on plasma glucose and triglyceride, and they were intraperitoneally injected with TAK-559 (1) and its metabolites (2-5) for 7 d. Compounds (1)(2)(3)(4)(5) were suspended in 0.5% methylcellulose saline solution. TAK-559 was injected into 3 groups of rats at the doses of 0.1, 0.3 and 1.0 mg/kg/d, and each metabolite was injected into 3 groups of rats at the doses of 0.3, 1.0 and 3.0 mg/kg/d.…”
Section: Experimental Biological Procedures (A)mentioning
confidence: 99%
“…IR spectra were recorded on a JASCO IR-810. 1 H-NMR spectra were recorded on a Varian Gemini-200 spectrometer in CDCl 3 or DMSO-d 6 using tetramethylsilane as an internal standard. Chemical shifts are expressed as d (ppm) values for protons relative to the internal standard.…”
Section: Experimental Biological Procedures (A)mentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, there is a need for more effective, orally active agents, particularly Thiazolidinediones (TZDs) that normalize both glucose and insulin levels (Adisakwattana et al, 2005). Thiazolidinedione (TZD) also known as ''glitazone'', are a unique new class of oral antidiabetic agents that exert direct effects on the mechanism of insulin resistance (Imoto et al, 2002). Chemically, the members of this class are derivatives of the parent compound thiazolidinedione.…”
Section: Introductionmentioning
confidence: 99%