Studies on organogelation of self assembling bis urea type low molecular weight molecules

Sravan, B.; Kamalakar, K.; Karuna, Mallampalli Sri Lakshmi; Palanisamy, Aruna

doi:10.1007/s10971-014-3386-5

Cited by 10 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This consideration has already been reported for bis-urea organogelators even if an increase of the alkyl chain length was usually related to an increase in the gel stability, 32,37 and only in a few cases a higher thermal stability was encountered in a homologous series for derivatives having shorter lateral chains. 38,39 FTIR spectroscopy FTIR measurements evidenced the role of urea groups in the gel formation. In fact, a comparison of those regions of the IR spectrum where the urea group gives the most significant peaks reveals non negligible shifts (Fig.…”

Section: Calorimetric Measurementsmentioning

confidence: 99%

Urea vs. carbamate groups: a comparative study in a chiral C₂symmetric organogelator

et al. 2015

View full text Add to dashboard Cite

The effect of the replacement of molecular moieties (carbamates vs. urea) that drive self-assembly for two organogelators with an identical C(2) symmetric molecular structure is described. The main properties of the gels obtained from the urea-based organogelators are also discussed. The proposed organogelators are chiral molecules and are able to express chirality also at the supramolecular level, thus allowing the employment of electronic circular dichroism to gain insight into the molecular-scale structure of fibrillar aggregates. With the same technique, the behavior of enantiomeric mixtures of the urea-based organogelators was investigated, revealing the occurrence of different self-sorting phenomena at the molecular and supramolecular scale. The urea-based organogelators demonstrated to be more efficient gelators with respect to the carbamate-based analogues, showing a high gel-to-sol transition temperature (up to 66 °C) and a very low minimum gelling concentration (0.85 mg mL(-1)). This study is a starting point for a deeper investigation of structure/property relationships and, taking into account the peculiar behavior detected for the enantiomeric mixtures, also of self-sorting and molecular recognition phenomena.

show abstract

Section: Calorimetric Measurementsmentioning

confidence: 99%

Urea vs. carbamate groups: a comparative study in a chiral C₂symmetric organogelator

et al. 2015

View full text Add to dashboard Cite

show abstract

“…34,35,43,44 Most acyl-semicarbazide-based gelators are bis(acyl-semicarbazide)s, with the majority coming from recent studies by the Palanisamy group. 33,36,45…”

Section: Introductionmentioning

confidence: 99%

“…1). [33][34][35][36] They can behave in a similar way to amide gelators that typically form amide to amide C(4) hydrogen bonding motifs in graph set nomenclature, 37 urea gelators that form R 1 2 (6) a-tapes or hydrazide gelators that form R 2 2 (10) synthons. This hydrogen bonding capacity makes their supramolecular self-assembly behaviour potentially very versatile and could yield responsive and effective low molecular weight gelators (LMWG).…”

Section: Introductionmentioning

confidence: 99%

Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs

Contreras-Montoya,

Smith,

Boothroyd

et al. 2023

Chem. Sci.

View full text Add to dashboard Cite

show abstract

“…Organogels are formed by gelators, which are foundational building blocks. Gelators are often certain low-molecular-mass substances (e.g., sorbitan derivatives, lecithin, fatty acid derivatives, bis-urea compounds) [3][4][5]. The gelators help in the formation of a 3D structure of a mesh network due to the entanglement of self-assembled fibrous structures, which are formed due to some physical or chemical interactions of gelators when used in the concentration of <15% (approx.)…”

Section: Introductionmentioning

confidence: 99%

Organogel: A Propitious Carman in Drug Delivery System

Bedse¹,

Singh²,

Raut³

et al. 2023

Advanced Drug Delivery Systems

View full text Add to dashboard Cite

A gel is a semi-solid formulation having an external solvent phase that is either apolar (organogels) or polar (hydrogels) that is immobilized inside the voids contained in a three-dimensional networked structure. Organogels are bi-continuous systems composed of apolar solvents and gelators. When used at a concentration of around 15%, the gelators form self-assembled fibrous structures that become entangled with one another, resulting in the formation of a three-dimensional networked structure. The resulting three-dimensional networked structure blocks the flow of the external apolar phase. Sterol, sorbitan monostearate, lecithin, and cholesteryl anthraquinone derivatives are examples of gelators. The unique characteristics such as thermo-reversibility, viscoelasticity, and versatility impart a longer shelf-life, prolonged drug release, and patient compliance. These characteristics can easily be adjusted by simple formulation modifications, resulting in highly-structured architectures. Organogels are more likely to be used in various types of delivery systems because of their ability to entrap both hydrophilic and hydrophobic molecules inside their structure. Their combination with other materials allows for tailoring their potential as dosage forms. Organogels have potential applicability in numerous ways; hence this article discusses the various aspects of it.

show abstract

Studies on organogelation of self assembling bis urea type low molecular weight molecules

Cited by 10 publications

References 31 publications

Urea vs. carbamate groups: a comparative study in a chiral C₂symmetric organogelator

Urea vs. carbamate groups: a comparative study in a chiral C₂symmetric organogelator

Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs

Organogel: A Propitious Carman in Drug Delivery System

Contact Info

Product

Resources

About

Studies on organogelation of self assembling bis urea type low molecular weight molecules

Cited by 10 publications

References 31 publications

Urea vs. carbamate groups: a comparative study in a chiral C2symmetric organogelator

Urea vs. carbamate groups: a comparative study in a chiral C2symmetric organogelator

Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs

Organogel: A Propitious Carman in Drug Delivery System

Contact Info

Product

Resources

About

Urea vs. carbamate groups: a comparative study in a chiral C₂symmetric organogelator

Urea vs. carbamate groups: a comparative study in a chiral C₂symmetric organogelator