Studies on Pepsin Secretion. I. Nocturnal and Hypoglycemic Secretion in Patients With Duodenal Ulcer And Without Gastro-Intestinal Disease

Antral function in duodenal ulcer

“…The present series, however, shows that the increased output of pepsin in duodenal ulcer patients is due to increased secretory volume and not increased concentration. This agrees with the findings of Hirschowitz (1957), Chinn, Book & Beams (1951), Chinn (1953), Book, Chinn & Beams (1952) and Yamagata (1966). The difference in concentration found by the' other workers is probably due to the fact that they overlooked the greater volume of gastric juice in duodenal ulcer patients which when added to the fixed volume of a test meal would result in apparently higher concentrations than in controls.…”

“…The present series agreed with the results of Chinn et al (1951) in that the relationship of pepsin secretion to acid secretion is inconstant-low pepsin levels may occur with high acid levels and vice versa.…”

The gastric secretion of pepsin in man

“…In dogs with innervated gastric pouches, this has been demonstrated by direct stimulation of the vagus nerves in the neck (Browne and Vineberg, 1932;Vineberg, 1933); in man, insulin-induced hypoglycaemia has been used to effect central excitation of the vagus nerves which in turn stimulated a gastric acid and pepsin secretory response (Ihre, 1938;Chinn, Book, and Beams, 1951;Janowitz and Hollander, 1952;Harrower, Brook, and Cooper, 1956). In contrast to our increasing knowledge of the effect of surgical vagotomy on acid secretion by the stomach little is known of its effect on spontaneous pepsin secretion.…”

Proteolytic activity in the human stomach during digestion and its correlation with the augmented histamine test.

“…The increasing amount of acid and pepsin secreted during this period seems to contradict this result, but formation of pepsin inhibitors during protein digestion can explain the relationship (Le Veen and Hallinger, 1947;Bucher, Grossman, and Ivy, 1945;Chinn, Book, and Beams, 1951).…”