Studies on physiologically active substances in citrus peel. Part II. Structure and hypotensive effect of flavonoid glycosides in Citrus unshiu peelings.

Matsubara, Yoshiharu; Kumamoto, Hiroyasu; Iizuka, Yoshitomi; Murakami, Tetsuo; Okamoto, Kozo; Miyake, Hideo; Yokoi, Katsumi

doi:10.1271/bbb1961.49.909

Cited by 44 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Buckwheat is known to have preventive and curative effects against certain chronic diseases such as diabetes (Kawa et al, 2003;Larner, 2002;Ortmeyer et al, 1995;Steadman et al, 2000), hypertension (Matsubara et al, 1985) and hypercholesterolemia (Sugiyama et al, 1985). It has also been recommended as a potential ingredient in the formulation of low glycemic index foods (Skrabanja et al, 2001).…”

Section: Embryomentioning

confidence: 99%

“…In Japan, Ohsawa & Tsutsumi, (1995) explored the possibility of increasing the rutin content of buckwheat through breeding programs owing to its importance in the functional food industry. Extensive research has established that rutin is beneficial in the treatment and prevention of rheological disorders of the blood such as capillary fragility which is associated with hypertension (Matsubara et al, 1985), as well as atherosclerosis (Wojcicki et al, 1995). It is also believed to be effective in reducing fasting blood glucose levels and increasing insulin levels (Hao et al, 2012;Yildizogluari et al, 1991).…”

Section: Embryomentioning

confidence: 99%

“…(Kawa et al, 2003;Larner, 2002;Ortmeyer et al, 1995;Steadman et al, 2000) Phytosterols Inhibition of cholesterol absorption (Lees et al, 1977;Mattson, Grundy, & Crouse, 1982) Thiamine-binding proteins Improvement of thiamine bioavailability (Mitsunaga et al, 1986) Rutin Treatment and prevention of rheological disorders of the blood, eg. Hypertension (Matsubara et al, 1985;Wojcicki et al, 1995) Other phenolic compounds Anti-inflammatory and antioxidant properties (Holasova et al, 2002;Griendling & FitzGerald, 2003;Molavi & Mehta, 2004) …”

Section: Embryomentioning

confidence: 99%

“…It is also rich in phenolic acids and flavonoids, many of which possess antioxidant activity (Holasova et al, 2002;Kreft et al, 2006;Oomah & Mazza, 1996;Przybylski et al, 1998). Buckwheat is regarded as one of the best sources of rutin, a flavonol glycoside which has been shown to be effective in the treatment and prevention of rheological disorders of the blood such as hypertension (Matsubara et al, 1985), and atherosclerosis (Wojcicki et al, 1995). In addition to being a healthy source of B-vitamins (Bonafaccia et al, 2003), polyunsaturated fatty acids (Steadman et al, 2001a), and minerals (Amarowicz & Fornal, 1987), buckwheat is also a rich source of dietary fibre (Bonafaccia et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Phenolic profile and carbohydrate digestibility of durum spaghetti enriched with buckwheat flour and bran

Biney

Beta

2014

LWT - Food Science and Technology

View full text Add to dashboard Cite

There is growing demand for functional foods and ingredients as a result of their healthpromoting properties. In this work, the potential of common buckwheat flour (Supreme) and bran (Farinetta) in improving upon the phenolic and antioxidant properties of durum spaghetti was investigated. The effects of processing and cooking on these properties were also studied in addition to the cooking quality and carbohydrate digestibility of spaghetti products. The presence of buckwheat significantly (p < 0.05) elevated total phenolic content (TPC), total flavonoids content (TFC), rutin and phenolic acids levels, in flours, uncooked and cooked spaghetti samples. Significant increments were also recorded for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) approaches. Among uncooked spaghetti samples, there were huge increments of between 114 and 522% for TPC, 50 and 242% for TFC, 359 and 1000% for DPPH antioxidant activity, and 101 and 197% for ORAC values of the experimental spaghetti samples over the control. Farinetta contributed more phenolic and antioxidant compounds than Supreme flour. Processing did not cause any significant losses in TPC, but losses ranging from 1.2 to 33.7% in TFC and 42.0 to 55.3% in DPPH antioxidant activity were incurred. Cooking generally resulted in significant losses (p < 0.05) of up to 39% in TPC, 40% in DPPH antioxidant activity, 22% in rutin content, and 55% in TFC among all buckwheat-containing products. Even after these

show abstract

Section: Embryomentioning

confidence: 99%

Section: Embryomentioning

confidence: 99%

Section: Embryomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phenolic profile and carbohydrate digestibility of durum spaghetti enriched with buckwheat flour and bran

Biney

Beta

2014

LWT - Food Science and Technology

View full text Add to dashboard Cite

show abstract

“…1). The compounds were identified as methyl nomilinate (1) [15], limocitrunshin (2) [7], nobiletin (3) [16], kaempferol 3-O-rutinoside (4) [17], limocitrin 3-glucoside (5) [18], kaempferol 3-(2 G -rhamnosylrutinoside) (6) [17], didymin (7) [19], (2S)-narirutin 4'-Oglucoside (8) [20] and naringenin 7-O-rutinoside (9) [21], respectively, based on comparison of their spectroscopic and physical data with those previously reported as well as by measurement of their specific rotations.…”

Section: Isolation and Structural Elucidation Of Compoundsmentioning

confidence: 99%

Chemical constituents from the fruits of Citrus unshiu and their inhibitory effects on acetylcholinesterase

Baek

Lee

Kang

et al. 2017

Maced. J. Chem. Chem. Eng.

View full text Add to dashboard Cite

Acetylcholinesterase (AChE) inhibition has been considered a promising temporary treatment for Alzheimer’s disease. The present study was conducted to isolate chemical constituents from the fruit of Citrus unshiu Markovich (Rutaceae) and evaluate their inhibitory effects on AChE. Phytochemical investigation of C. unshiu fruit led to the isolation of methyl nomilinate (1), limocitrunshin (2), nobiletin (3), kaempferol 3-O-rutinoside (4), limocitrin 3-glucoside (5), kaempferol 3-(2G-rhamnosylrutinoside) (6), didymin (7), (2S)-narirutin 4'-O-glucoside (8) and naringenin 7-O-rutinoside (9). The structures were identified with 1H and 13C NMR spectroscopic data and ESI-MS, then comparison of their spectroscopic and physical data with those previously reported, as well as by measurement of their specific rotations. A limonoid, methyl nomilinate (1), inhibited AChE activity by more than 50% at a concentration of 30 μg/ml. The findings in this study provide the first experimental evidence that a limonoid compound 1 from C. unshiu fruit acts as a natural AChE inhibitor.

show abstract

Comparative phytochemical study of methanolic and ethanolic extracts of Thymus linearis and their antibacterial and antioxidant potential

Nadeem,

Pervaiz,

Ejaz

et al. 2024

Biomedical Chromatography

View full text Add to dashboard Cite

Thymus linearis (Thyme) is a medicinal plant widely distributed throughout Asia. Various parts of thyme are utilized for diverse medicinal purposes, including its use as a tonic and diuretic, for cough relief, as a flavoring agent, in treating dysentery, and for alleviating stomach disorders. Numerous studies have been conducted to explore the unexploited potential of thyme. Thyme was collected from the northern region of Pakistan, and sun‐mediated extraction was conducted. Phytochemical analysis, utilizing GC–MS, revealed numerous bioactive phytochemical constituents with disease‐preventing roles, including detoxifying agents, antioxidants, anticancer compounds, dietary fiber, neuropharmacological agents, and immunity‐potentiating agents, in the methanolic and ethanolic (14 days) extracts of the flower, leaf, and stem. The 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) assay results indicated that the ethanolic and methanolic extracts of the stem exhibited the highest antioxidant activity, reaching up to 67.34% and 62.73%, respectively, while the values for the flower and leaf extracts (both methanol and ethanol) were around 60%. The IC50 (half maximal inhibitory concentration) values were also calculated for all the samples, ranging between 7 and 9 μg/mL. Positive antibacterial and antifungal effects against Bacillus subtilis and Escherichia coli, as well as Aspergillus niger (fungi), were observed only in the extracts of the flower (both methanol and ethanol). The sun‐mediated technique was used for extraction for the first time in this study. Therefore, this study introduces a novel approach to the extraction of bioactive compounds from medicinal plants, ultimately contributing to the development of herbal drugs with more convenient and cost‐effective methods.

show abstract

Studies on physiologically active substances in citrus peel. Part II. Structure and hypotensive effect of flavonoid glycosides in Citrus unshiu peelings.

Cited by 44 publications

References 0 publications

Phenolic profile and carbohydrate digestibility of durum spaghetti enriched with buckwheat flour and bran

Phenolic profile and carbohydrate digestibility of durum spaghetti enriched with buckwheat flour and bran

Chemical constituents from the fruits of Citrus unshiu and their inhibitory effects on acetylcholinesterase

Comparative phytochemical study of methanolic and ethanolic extracts of Thymus linearis and their antibacterial and antioxidant potential

Contact Info

Product

Resources

About