Studies on polymer-coated zinc oxide nanoparticles: UV-blocking efficacy and in vivo toxicity

Girigoswami, Koyeli; Meenakshi, V.; Murugesan, Ramachandran; Girigoswami, Agnishwar

doi:10.1016/j.msec.2015.07.017

Cited by 81 publications

(49 citation statements)

References 21 publications

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“…In the last few years, several methods were investigated to restrict the damage caused by UV irradiation, namely the use of additives such as silsesquioxanes [14] and inorganic [15] or organic copolymers [16]. To protect the PDMS films, some researchers have also envisaged the deposition of ZnO or ZnO-doped quantum dots in the form of multilayers to obtain a UV-blocking material [17,18]. Another drawback of PDMS results from the insufficient thermal stability of the polymer when used as thermal control coating [19].…”

Section: Introductionmentioning

confidence: 99%

Polydimethylsiloxane/Additive Systems for Thermal and Ultraviolet Stability in Geostationary Environment

Planes¹,

Coz²,

Soum³

et al. 2016

Journal of Spacecraft and Rockets

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The development of radiation resistant materials is an ongoing challenge for space industry. High-energy irradiation (ultraviolet, electrons, neutrons, protons) induce damage to materials and electronic components in spaceships. Silicone resins are often used and play a key role as coatings and adhesive materials for satellites. Polydimethylsiloxanes show material exhaustion after long-term exposure to ultraviolet irradiation. Consequently, solutions are required to increase their thermo-and photostability under solar irradiation. Three different families of additives, namely ultraviolet absorbers, hindered amine light stabilizers, and a carbazole derivative are investigated. Those ultraviolet stabilizers were mixed with polydimethylsiloxane, then a cross-linking process was run by hydrosilylation. When ultraviolet absorbers could not be used due to a miscibility problem, addition of 0.5 wt % of bis (2,2,6,6-tetramethylpiperidin-4-yl)decanedioate (hindered amine light stabilizer 1) was shown to increase the thermal stability, measured by thermogravimetric analysis, from 360 to 395°C (Td 5%). Using visible near-infrared spectroscopy and after 450 equivalent solar hours of ultraviolet irradiation, an average increase of 2.6% in the ultraviolet stability was also obtained in the wavelength range from 250 to 400 nm. A polydimethylsiloxane/ dibromocarbazole 1.0 wt% did not improve the ultraviolet stability but exhibited a strong increase (about 100°C) of the degradation temperature of the polydimethylsiloxane.

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Section: Introductionmentioning

confidence: 99%

Polydimethylsiloxane/Additive Systems for Thermal and Ultraviolet Stability in Geostationary Environment

Planes¹,

Coz²,

Soum³

et al. 2016

Journal of Spacecraft and Rockets

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“…This problem has been overcome by reducing at the nanometric level the diameter of the particles. However, the nanomaterial employment in sunscreen products raises remarkable issues regarding their safety towards human health and environment, especially due to their enhanced photocatalytical activity [14,15].…”

Section: Introductionmentioning

confidence: 99%

A New Approach to UV Protection by Direct Surface Functionalization of TiO2 with the Antioxidant Polyphenol Dihydroxyphenyl Benzimidazole Carboxylic Acid

et al. 2020

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Skin cancer is the most common malignant cancer with an incidence of 1 million cases/year. It is well known that exposure to UV radiation from sunlight leads the most frequent risk factors for several skin disorders including skin cancer. Sunscreen filters represent a valid protection against dangerous effects derived from UV radiation, and they can be divided in organic and inorganic UV filters. Adding, at the product formulation, molecules with booster effect, or also substances that can increase the protecting effectiveness via synergic mechanisms, can further enhance their protection activity. Moreover, this approach leads to develop formulations with high SPF (Sun Protection Factor) with a reduced content of UV filters, this is in line with the recent decisions of yet a few countries (Palau, Thailand, Philippines, and Hawaii) to ban some sunscreen filters to preserve marine environments (i.e., reef). In this work, a new class of sunscreen UV filters has been synthesized, by means the combination of physical filter and Oxisol, an antioxidant molecule with booster effect. In this study, the synthesis of new physical multifunctional ingredients is reported, by means the direct surface functionalization of inorganic filters (in particular TiO2) with Oxisol. In this study, the full characterization of these multifunctional ingredients is also reported, in addition to the cytotoxicity tests, the photocatalytic activity and the rheological properties involved on skin application.

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“…For biomedical applications, it is critical for NPs to be chemically and colloidally stable as well as biocompatible [19,22]. While ZnO NPs are generally understood to be cytotoxic [41][42][43][44][45][46], surface modification may limit this toxicity [47][48][49][50][51][52][53] and targeting of the particles may allow for directed cell killing while leaving non-targeted cells unharmed. ZnO particles linked to Dye 847 (Dye 847-ZnO NPs) were characterized and surface-modified by coating with poly (ethylene glycol) (PEG) to increase particle biocompatibility and reduce aggregation [54][55][56][57][58].…”

Section: Introductionmentioning

confidence: 99%

Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

Nagi

Skorenko²,

Bernier

et al. 2019

Materials

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Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (<30 μg/mL), but viability significantly decreased at higher particle concentrations, suggesting a need for particle surface modification with poly (ethylene glycol) (PEG) for improved biocompatibility. The presence of PEG on particles after dialysis was indicated by an increase in size, an increase in zeta potential towards neutral, and spectroscopy results. Cell viability was improved in the absence of irradiation when cells were exposed to PEG-coated, dye-linked ZnO particles compared to non-surface modified particles. The present study shows that there is potential for biological application of dye-linked ZnO particles in photodynamic therapy.

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Studies on polymer-coated zinc oxide nanoparticles: UV-blocking efficacy and in vivo toxicity

Cited by 81 publications

References 21 publications

Polydimethylsiloxane/Additive Systems for Thermal and Ultraviolet Stability in Geostationary Environment

Polydimethylsiloxane/Additive Systems for Thermal and Ultraviolet Stability in Geostationary Environment

A New Approach to UV Protection by Direct Surface Functionalization of TiO2 with the Antioxidant Polyphenol Dihydroxyphenyl Benzimidazole Carboxylic Acid

Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

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