Studies on Polymorphonuclear Leukocyte Bactericidal Function

Simms, Henry S.; D'Amico, R

doi:10.1097/00024382-199702000-00002

Cited by 18 publications

(17 citation statements)

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“…TNF-␣ and IL-1 affect many of these factors, with diverse and often competing effects on bacterial burden (28). For example, TNF-␣ and IL-1 can activate macrophages and neutrophils (55), which increases the killing of bacteria and decreases bacterial burden. TNF-␣ can cause cell death (2), which makes nutrients available to bacteria and increases bacterial burdens.…”

Section: Discussionmentioning

confidence: 99%

Roles for early response cytokines duringEscherichia colipneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1

Mizgerd¹,

Lupa²,

Hjoberg³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionmentioning

confidence: 99%

Roles for early response cytokines duringEscherichia colipneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1

Mizgerd¹,

Lupa²,

Hjoberg³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…We speculate that overactivation of glucocorticoid regulation, as occurred in absence of V␥2V␦2 T cells, might affect severity of infectious disease. Furthermore, in absence of V␥2V␦2 T cells, MIF, TNF-␣, and IL-1␤, three pleiotropic and important cytokines for host resistance to bacterial infection (8,(51)(52)(53)(54)(55)(56)(57), had reduced production or secretion. The relative overactivity of glucocorticoids and reduced levels of cytokine production and secretion might account for the severity of bacterial infection in vivo.…”

Section: Discussionmentioning

confidence: 99%

Human Vγ2Vδ2 T Cells Augment Migration-Inhibitory Factor Secretion and Counteract the Inhibitory Effect of Glucocorticoids on IL-1β and TNF-α Production

Wang

Das

Kamath

et al. 2002

The Journal of Immunology

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In immune cells, proinflammatory cytokine gene expression is regulated by glucocorticoids, whereas migration-inhibitory factor (MIF), a pleiotropic cytokine, has the unique property of counteracting the inhibitory effect of glucocorticoids on TNF-α and IL-1β secretion. A few lines of evidence suggest that γδ T cells play an important role in immunoregulation. However, it is unknown whether human γδ T cells participate in regulating MIF secretion, and how γδ T cells, glucocorticoids, and cytokines converge to give a unified physiological response. In this study, we demonstrate that human Vγ2Vδ2 T cells augment MIF secretion. Remarkably, these Vγ2Vδ2 T cells, functioning similarly to MIF in part, counteracted inhibition of dexamethasone on production of IL-1β and TNF-α. SCID mice reconstituted with human PBMC that were mock depleted of Vδ2 T cells and repeatedly infected with lethal dose of Escherichia coli had shorter survival time than those reconstituted with PBMC that were depleted of Vδ2 T cells. Thus, human Vγ2Vδ2 T cells are likely to play broad-spectrum roles in immunoregulation and immunopathology by influencing MIF secretion and the immunomodulatory function of glucocorticoids.

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“…Interleukin-1 and IL-6 stimulate leukocyte chemotaxis, T and B cell activity and PMN bactericidal activity [29][30][31]. A decreased capacity of wound cells to release proinflammatory cytokines following glucocorticoid treatment in mice has been reported to be associated with an increased rate of wound complications [32,33].…”

Section: Discussionmentioning

confidence: 99%

<i>L</i>-Arginine: A Unique Amino Acid for Improving Depressed Wound Immune Function following Hemorrhage

et al. 2002

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Objective: To determine whether L-arginine has any salutary effects on wound immune cell function following trauma-hemorrhage. Background: Depressed wound immune function contributes to an increased incidence of wound infections following hemorrhage. Although administration of L-arginine has been shown to restore depressed cell-mediated immune responses following hemorrhage potentially by maintaining organ blood flow, it remains unknown whether L-arginine has any salutary effects on the depressed local immune response at the wound site. Methods: Male mice were subjected to a midline laparotomy and polyvinyl sponges were implanted subcutaneously in the abdominal wound prior to hemorrhage (35 ± 5 mm Hg for 90 min and resuscitation) or sham operation. During resuscitation mice received 300 mg/kg body weight L-arginine or saline (vehicle). Sponges were harvested 24 h thereafter, wound fluid collected and wound immune cells cultured for 24 h in the presence of LPS. Pro- (IL-1β, IL-6) and anti-inflammatory (IL-10) cytokines were determined in the supernatants and the wound fluid. In addition, wounds were stained for IL-6 immunohistochemically. In a separate set of animals, skin and muscle blood flow was determined by microspheres. Results: The capacity of wound immune cells to release IL-1β and IL-6 in vitro was significantly depressed in hemorrhaged mice receiving vehicle. Administration of L-arginine, however, improved wound immune cell function. In contrast, in vivo the increased IL-6 release at the wound site was decreased in L-arginine-treated mice following hemorrhage. Moreover, IL-10 levels were significantly increased in the wound fluid in hemorrhaged animals receiving L-arginine compared to vehicle-treated mice. In addition, the depressed skin and muscle blood flow after hemorrhage was restored by L-arginine. Conclusions: Thus, L-arginine might improve local wound cell function by decreasing the inflammatory response at the wound site. Since L-arginine protected wound immune cell function this amino acid might represent a novel and useful adjunct to fluid resuscitation for decreasing wound complications following hemorrhage.

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Studies on Polymorphonuclear Leukocyte Bactericidal Function

Cited by 18 publications

References 0 publications

Roles for early response cytokines duringEscherichia colipneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1

Roles for early response cytokines duringEscherichia colipneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1

Human Vγ2Vδ2 T Cells Augment Migration-Inhibitory Factor Secretion and Counteract the Inhibitory Effect of Glucocorticoids on IL-1β and TNF-α Production

<i>L</i>-Arginine: A Unique Amino Acid for Improving Depressed Wound Immune Function following Hemorrhage

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