Studies on possible protective effect of plant derived phenols and the vitamin precursors—β‐Carotene and α‐tocopherol on 7,12 dimethylbenz (a) anthracene induced tumour initiation events

Moushumi, Lahiri; Sumati, Bhide

doi:10.1002/ptr.2650080410

Cited by 8 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interactions between nutrients and contaminants can enhance the protection against negative effects of unwanted compounds. For example, vitamin E (tocopherols), flavonoids, and fatty acids amend the toxicity of polycyclic aromatic hydrocarbons (PAHs) and pesticides [ 1 , 2 , 3 ]. The mechanisms underlying such interactions are however often not very well characterized.…”

Section: Introductionmentioning

confidence: 99%

Modifying Effects of Vitamin E on Chlorpyrifos Toxicity in Atlantic Salmon

Berntssen¹,

Søfteland²

2015

PLoS ONE

View full text Add to dashboard Cite

The aim of this study was to elucidate how vitamin E (alpha tocopherol) may ameliorate the toxicity of the pesticide chlorpyrifos in Atlantic salmon. Freshly isolated hepatocytes were exposed to vitamin E, chlorpyrifos or a combination of vitamin E and chlorpyrifos (all 100 μM). Transcriptomics (RNA-seq) and metabolomics were used to screen for effects of vitamin E and chlorpyrifos. By introducing vitamin E, the number of upregulated transcripts induced by chlorpyrifos exposure was reduced from 941 to 626, while the number of downregulated transcripts was reduced from 901 to 742 compared to the control. Adding only vitamin E had no effect on the transcriptome. Jak-STAT signaling was the most significantly affected pathway by chlorpyrifos treatment according to the transcriptomics data. The metabolomics data showed that accumulation of multiple long chain fatty acids and dipeptides and amino acids in chlorpyrifos treated cells was partially alleviated by vitamin E treatment. Significant interaction effects between chlorpyrifos and vitamin E were seen for 15 metabolites, including 12 dipeptides. The antioxidant had relatively modest effects on chlorpyrifos-induced oxidative stress. By combining the two data sets, the study suggests that vitamin E supplementation prevents uptake and accumulation of fatty acids, and counteracts inhibited carbohydrate metabolism. Overall, this study shows that vitamin E only to a moderate degree modifies chlorpyrifos toxicity in Atlantic salmon liver cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Modifying Effects of Vitamin E on Chlorpyrifos Toxicity in Atlantic Salmon

Berntssen¹,

Søfteland²

2015

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Vitamin E is protective against approximately 80 diseases, such as cancer, cardiovascular diseases (1), cell membrane and DNA damage by free radicals, oxidation of low-density lipoproteins, and disorders of the skin, eye, lungs, and other lipid-rich body constituents (2)(3)(4)(5)(6)(7)(8)(9). R-Tocopherol, the most common form of vitamin E present in nature, is the most biologically active (10), and is preferentially retained in large quantities and transported to body components (11).…”

Section: Introductionmentioning

confidence: 99%

Alpha-Tocopherol Content in 62 Edible Tropical Plants

Ching

Mohamed

2001

J. Agric. Food Chem.

225

122

View full text Add to dashboard Cite

Vitamin E was determined by the high-performance liquid chromatography (HPLC) method. All the plants tested showed differences in their alpha-tocopherol content and the differences were significant (p < 0.05). The highest alpha-tocopherol content was in Sauropus androgynus leaves (426.8 mg/kg edible portion), followed by Citrus hystrix leaves (398.3 mg/kg), Calamus scipronum (193.8 mg/kg), starfruit leaves Averrhoa belimbi (168.3 mg/kg), red pepper Capsicum annum (155.4 mg/kg), local celery Apium graveolens (136.4 mg/kg), sweet potato shoots Ipomoea batatas (130.1 mg/kg), Pandanus odorus (131.5 mg/kg), Oenanthe javanica (146.8 mg/kg), black tea Camelia chinensis (183.3 mg/kg),papaya Carica papaya shoots (111.3 mg/kg), wolfberry leaves Lycium chinense (94.4 mg/kg), bird chili Capsicum frutescens leaves (95.4 mg/kg), drumstick Moringa oleifera leaves (90.0 mg/kg), green chili Capsicum annum (87 mg/kg), Allium fistulosum leaves (74.6 mg/kg), and bell pepper Capsicum annum (71.0 mg/kg). alpha-Tocopherol was not detected in Brassica oleracea, Phaeomeria speciosa, Pachyrrhizus speciosa, Pleurotus sajor-caju, and Solanum melongena.

show abstract

“…Over the last 50 years, the incidence rates of both MM and NMSC have increased, with MM showing a 0.6% increase among adults (91). In a study investigating the effect of HC on DNA biosynthesis in a female Swiss mice model of skin cancer, exposing the mice to 1 mg/day of HC demonstrated the ability to restore normal DNA biosynthesis in skin exposed to the carcinogen dimethylbenz[a]anthracene (92).…”

Section: Colorectal Cancer (Crc)mentioning

confidence: 99%

“…In a study investigating the effect of HC on DNA biosynthesis in a female Swiss mice model of skin cancer, exposing the mice to 1 mg/day of HC demonstrated the ability to restore normal DNA biosynthesis in skin exposed to the carcinogen dimethylbenz[a]anthracene ( 92 ).…”

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

Hydroxychavicol as a potential anticancer agent (Review)

2022

View full text Add to dashboard Cite

Piper betle leaves are widely cultivated in Malaysia, India, Indonesia and Thailand. They have been used as a traditional medicine for centuries due to their medicinal properties, including antioxidant, antiproliferative, antibacterial, antifungal and anti-inflammatory properties, which are attributable to their high phenolic contents. Hydroxychavicol (HC), a primary constituent of P. betle leaves, is known to possess antiproliferative activity at micromolar doses on various cancer cell lines of different origins while leaving normal cells unharmed. The present review summarises the mechanisms of action of HC reported in the literature, reviews the scope of work done thus far and outlines the direction of future research on the potential of HC as an anticancer agent. PubMed, Scopus and Web of Science were searched using the keywords (hydroxychavicol OR 4-allylpyrocatechol OR 4-allylcatechol) AND (cancer OR carcinogenesis OR tumour OR carcinoma) to acquire research articles. In vitro studies reported several possible mechanisms for the chemopreventive effects of HC against cancer cell lines, including chronic myelogenous leukaemia (CML), prostate, glioma, breast and colorectal cancers, while in vivo studies encompassed investigations on Ehrlich ascites carcinoma cells in Swiss albino mice and a CML mouse model. These studies suggest that HC exerts its anticancer effect via the modulation of mitochondrial membrane potential and the c-Jun N-terminal kinase, mitogen-activated protein kinase and endoplasmic reticulum-unfolded protein responses pathways and the generation of reactive oxygen species. In summary, future research should focus on combinations of HC with other anticancer drugs and testing in animal models to evaluate its bioavailability, potency and tissue and dose selectivity. Contents 1. Introduction 2. Methods 3. Composition of HC 4. In vitro and in vivo studies 5. Anti-inflammatory activity of HC 6. Conclusions and prospects

show abstract

Studies on possible protective effect of plant derived phenols and the vitamin precursors—β‐Carotene and α‐tocopherol on 7,12 dimethylbenz (a) anthracene induced tumour initiation events

Cited by 8 publications

References 12 publications

Modifying Effects of Vitamin E on Chlorpyrifos Toxicity in Atlantic Salmon

Modifying Effects of Vitamin E on Chlorpyrifos Toxicity in Atlantic Salmon

Alpha-Tocopherol Content in 62 Edible Tropical Plants

Hydroxychavicol as a potential anticancer agent (Review)

Contact Info

Product

Resources

About