Studies on Pyridazinone Derivatives. XVI. Analgesic-Antiinflammatory Activities of 3 (2H)-Pyridazinone Derivatives

Studies on Some 3(2H)-Pyridazinone Derivatives with Antinociceptive Activity

“…Recently it was reported that a considerable number of 3(2H)-pyridazinone derivatives have analgesic activity [6,[13][14][15][16][17][18] . Among these compounds, one of the 3(2H)-pyridazinone derivatives, 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (emorfazone) is a well-known analgesic and antiinflammatory agent ( Figure 1) [13,14] .…”

A convenient and facile synthesis of pyridine, pyridazine, pyrimido-[4,5-c]pyridazine, pyrido[3,4-c]pyridazine, 1,6-naphthyridine and phthalazine derivatives

“…A considerable number of pyridazine derivatives were found to have analgesic [1], antibacterial [2], anticonvulsant [3], antiinflammatory [4], acetylcholin-esterase inhibition [5], aldose reductase inhibition and oxidant properties [6].…”

Synthesis and antimicrobial, acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3 (2H)-pyridazinone

“…Some of the presentdaydrugsincluding emorfazone [14](analgesic),pimobendan [15](positivei notropic, vasodilator),levosimendan [16](calciumsensitizer),imazodan [17](cardiotonic),zardaverin [18](cardiotonic), amrinone [19](plateletaggregation inhibitor),milrinone [20](phosphodiesteraseinhibitor)arethe best examples forpotentmoleculespossessing apyridazinone nucleus. Duetothe favorable presenceo fapyridazinone moiety in knownactivestructures,pyridazinone derivatives provoked aspecialinterest in the searchfornewanalgesic, anti-inflammatory [21][22][23][24][25][26][27][28]a nd antimicrobial [29][30][31]agents.…”