Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations

Kackar, Reena; Srivastava, M. K.; Raizada, R. B.

doi:10.1002/(sici)1099-1263(199711/12)17:6<369::aid-jat449>3.3.co;2-h

Cited by 11 publications

(14 citation statements)

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“…A rat study conducted in 1985 demonstrated that both EBDCs maneb and zineb could affect endogenous TRH at the pituitary or hypothalamic level and therefore inhibit TSH secretion (141). At the level of the thyroid gland, Mancozeb was shown to reduce TPO activity, consequently altering both weight and histopathology of the thyroid gland, with acute high dose exposure resulting in a hypothyroid status in rats (142,143). A zebrafish study exposed embryos to 0.001-10 µM thiram, at various developmental stages for a short duration of time (1 h).…”

Section: In Vivo Evidence Of Thyroid Disruption From Animal Studiesmentioning

confidence: 99%

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

et al. 2019

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Plant Protection Products, more commonly referred to as pesticides and biocides, are used to control a wide range of yield-reducing pests including insects, fungi, nematodes, and weeds. Concern has been raised that some pesticides may act as endocrine disrupting chemicals (EDCs) with the potential to interfere with the hormone systems of non-target invertebrates and vertebrates, including humans. EDCs act at low doses and particularly vulnerable periods of exposure include pre-and perinatal development. Of critical concern is the number of pesticides with the potential to interfere with the developing nervous system and brain, notably with thyroid hormone signaling. Across vertebrates, thyroid hormone orchestrates metamorphosis, brain development, and metabolism. Pesticide action on thyroid homeostasis can involve interference with TH production and its control, displacement from distributor proteins and liver metabolism. Here we focused on thyroid endpoints for each of the different classes of pesticides reviewing epidemiological and experimental studies carried out both in in vivo and in vitro. We conclude first, that many pesticides were placed on the market with insufficient testing, other than acute or chronic toxicity, and second, that thyroid-specific endpoints for neurodevelopmental effects and mixture assessment are largely absent from regulatory directives.

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Section: In Vivo Evidence Of Thyroid Disruption From Animal Studiesmentioning

confidence: 99%

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

et al. 2019

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“…Mancozeb is an agricultural fungicide that, at different oral doses, shows the ability to reduce iodine uptake and reduce serum T4 levels in dams and adult rats (Kackar et al 1997, Axelstad et al 2011. In addition, a study of the thyroid axis using adult male birds exposed to Mancozeb for 30 days showed an increase in thyroid size, an increase in plasma TSH levels and a decrease in T4 and T3 levels, mainly during the breeding phase (Pandey & Mohanty 2015).…”

Section: Journal Of Molecular Endocrinologymentioning

confidence: 99%

Thyroid function disruptors: from nature to chemicals

Oliveira

Chiamolera

Giannocco

et al. 2019

Journal of Molecular Endocrinology

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The modern concept of thyroid disruptors includes man-made chemicals and bioactive compounds from food that interfere with any aspect of the hypothalamus-pituitary-thyroid axis, thyroid hormone biosynthesis and secretion, blood and transmembrane transport, metabolism and local action of thyroid hormones. This review highlights relevant disruptors that effect populations through their diet: directly from food itself (fish oil and polyunsaturated fatty acids, pepper, coffee, cinnamon and resveratrol/grapes), through vegetable cultivation (pesticides) and from containers for food storage and cooking (bisphenol A, phthalates and polybrominated diphenyl ethers). Due to the vital role of thyroid hormones during every stage of life, we review effects from the gestational period through to adulthood, including evidence from in vitro studies, rodent models, human trials and epidemiological studies.

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“…Ten pesticides have been investigated regarding an intrathyroidal site of action, mainly in male rats (Table 5). Amitrole, ethylene thiourea, and mancozeb inhibit thyroid peroxidase (46)(47)(48). These three chemicals are members of the group of pesticides that produce high thyroid tumor incidences (Group I, Table 1).…”

Section: Perturbations In Thyroid-pituitary Functioningmentioning

confidence: 99%

“…Five pesticides are reported to inhibit iodide uptake into the thyroid (Table 5); however, for two of these, ethiozin and pentachloronitrobenzene, the data are incomplete and are difficult to interpret. For amitrole, ethylene thiourea, and mancozeb, it is not known whether the reduced iodide uptake is due to a specific block in the active transport of inorganic iodide into the cell (iodide pump) or whether it is simply a manifestation of the inhibition of thyroid peroxidase, due to the fact that the iodide is not trapped within the cell in an organic form (15,(46)(47)(48). Further work is required to differentiate these possibilities.…”

Section: Perturbations In Thyroid-pituitary Functioningmentioning

confidence: 99%

Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents.

Hurley

1998

Environ Health Perspect

283

115

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Of 240 pesticides screened for carcinogenicity by the U.S. Environmental Protection Agency Office of Pesticide Programs, at least 24 (10%) produce thyroid follicular cell tumors in rodents. Thirteen of the thyroid carcinogens also induce liver tumors, mainly in mice, and 9 chemicals produce tumors at other sites. Some mutagenic data are available on all 24 pesticides producing thyroid tumors. Mutagenicity does not seem to be a major determinant in thyroid carcinogenicity, except for possibly acetochlor; evidence is less convincing for ethylene thiourea and etridiazole. Studies on thyroid-pituitary functioning, including indications of thyroid cell growth and/or changes in thyroxine, triiodothyronine, or thyroid-stimulating hormone levels, are available on 19 pesticides. No such antithyroid information is available for etridiazole, N-octyl bicycloheptene dicarboximide, terbutryn, triadimefon, and trifluralin. Of the studied chemicals, only bromacil lacks antithyroid activity under study conditions. Intrathyroidal and extrathyroidal sites of action are found: amitrole, ethylene thiourea, and mancozeb are thyroid peroxidase inhibitors; and acetochlor, clofentezine, fenbuconazole, fipronil, pendimethalin, pentachloronitrobenzene, prodiamine, pyrimethanil, and thiazopyr seem to enhance the hepatic metabolism and excretion of thyroid hormone. Thus, with 12 pesticides that mode of action judgments can be made, 11 disrupt thyroid-pituitary homeostasis only; no chemical is mutagenic only; and acetochlor may have both antithyroid and some mutagenic activity. More information is needed to identify other potential antithyroid modes of thyroid carcinogenic action.

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Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations

Cited by 11 publications

References 0 publications

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Thyroid function disruptors: from nature to chemicals

Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents.

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