Studies on Riboflavin Metabolism in the Rat. IV. Riboflavin Elimination after Exclusion of the Portal Circulation

Christensen, Sten

doi:10.1111/j.1600-0773.1969.tb00482.x

Cited by 4 publications

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“…This indicated that the vitamin was metabolized in the body and a subsequent study (CHRISTENSEN 1969b) suggested that the liver is the site of metabolism. This indicated that the vitamin was metabolized in the body and a subsequent study (CHRISTENSEN 1969b) suggested that the liver is the site of metabolism.…”

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Studies on Riboflavin Metabolism in the Rat. V. Degradation of Riboflavin‐2‐¹⁴C

Christensen

1971

Acta Pharmacologica et Toxicologica

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Riboflavin-2-14C was administered orally or intraperitoneally to female Wistar rats in order to study the metabolic fate of the vitamin. Almost all the radioactivity was found in the urine, faeces, carcass and expired COe within 24 hours. The chemical recovery of riboflavin was lower, indicating partial degradation. Approximately 1 % of the radioactivity was recovered as 14COg. Following oral administration more than half of the radioactivity excreted in the urine was in the form of metabolites. Paper chromatography of urine revealed three unidentified labelled metabolites. After intraperitoneal administration only negligible amounts of non-riboflavin radioactivity were present in the urine. It is suggested from these data that the enzymes responsible for the degradation were saturated at the highest plasma concentrations reached. It is concluded that riboflavin, ingested orally within the dose range of 0.08 to 2.5 mg/rat, is eliminated to equal extents by degradation and by urinary excretion. This also seems to be the case at physiological conditions of vitamin intake.

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confidence: 95%