Studies on salmonellosis in the house mouse, <i>Mus musculus</i>

Shimi, A; Keyhani, Massoud; Hedayati, Khosrow

doi:10.1258/002367779781071258

Cited by 23 publications

(14 citation statements)

References 5 publications

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“…Serovar Stanley has not previously been reported to be virulent in mice although it has been isolated from rats and is a human pathogen [29]–[34]. Serovars Thompson, Poona, Paratyphi A, and Infantis have never been shown to cause disease in mice, consistent with the results in this study, but they have been isolated from wild mice and rats [35], [36] and from laboratory mice [37]. Consistent with this, we observed that our isolates of Thompson, Poona, and Infantis were recovered from feces two to three weeks after inoculation.…”

Section: Discussionsupporting

confidence: 87%

Virulence of 32 Salmonella Strains in Mice

et al. 2012

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Virulence and persistence in the BALB/c mouse gut was tested for 32 strains of Salmonella enterica for which genome sequencing is complete or underway, including 17 serovars within subspecies I (enterica), and two representatives of each of the other five subspecies. Only serovar Paratyphi C strain BAA1715 and serovar Typhimurium strain 14028 were fully virulent in mice. Three divergent atypical Enteritidis strains were not virulent in BALB/c, but two efficiently persisted. Most of the other strains in all six subspecies persisted in the mouse intestinal tract for several weeks in multiple repeat experiments although the frequency and level of persistence varied considerably. Strains with heavily degraded genomes persisted very poorly, if at all. None of the strains tested provided immunity to Typhimurium infection. These data greatly expand on the known significant strain-to-strain variation in mouse virulence and highlight the need for comparative genomic and phenotypic studies.

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Section: Discussionsupporting

confidence: 87%

Virulence of 32 Salmonella Strains in Mice

et al. 2012

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“…76 Differential diagnoses for E. cuniculi infection in mice include infection with Clostridium piliforme (Tyzzer's disease), Corynebacterium kutscheri (pseudotuberculosis), Pseudomonas aeruginosa, salmonellosis, mouse hepatitis virus, ectromelia virus (mousepox), and hematopoietic/lymphoreticular neoplasms. 3,36,46,54,57,62,127 In addition to E. cuniculi infection, experimental E. intestinalis and E. hellem, but not Enterocytozoon bieneusi, infections have been documented in immunocompromised mice. Intestinal and systemic E. intestinalis infections have been documented in several strains of immunosuppressed mice.…”

Section: Infection In Micementioning

confidence: 99%

Mammalian Microsporidiosis

2000

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Abstract. The phylum Microspora contains a diverse group of single-celled, obligate intracellular protozoa sharing a unique organelle, the polar filament, and parasitizing a wide variety of invertebrate and vertebrate animals, including insects, fish, birds, and mammals. Encephalitozoon cuniculi is the classic microsporidial parasite of mammals, and encephalitozoonosis in rabbits and rodents has been and continues to be recognized as a confounding variable in animal-based biomedical research. Although contemporary research colonies are screened for infection with this parasite, E. cuniculi remains a cause of morbidity and mortality in pet and conventionally raised rabbits. In addition, E. cuniculi is a potential pathogen of immature domestic dogs and farm-raised foxes. The recent discovery and identification of Encephalitozoon intestinalis, Encephalitozoon hellem, and Enterocytozoon bieneusi, in addition to E. cuniculi, as opportunistic pathogens of humans have renewed interest in the Microspora. Veterinary pathologists, trained in the comparative anatomy of multiple animal species and infectious disease processes, are in a unique position to contribute to the diagnosis and knowledge of the pathogenesis of these parasitic diseases. This review article covers the life cycle, ultrastructure, and biology of mammalian microsporaidia and the clinical disease and lesions seen in laboratory and domestic animals, particularly as they relate to Encephalitozoon species. Human microsporidial disease and animal models of human infection are also addressed. Often thought of as rabbit pathogens of historical importance, E. cuniculi and the related mammalian microsporidia are emerging as significant opportunistic pathogens of immunocompromised individuals.

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“…Wild populations harbor food-borne pathogens, especially diseasecausing strains of E. coli, Salmonella, and Listeria (Blackwell, 1981;Fenlon, 1999;Inoue et al, 1992;Ryser and Marth, 1999;Scott, 1959a;Scott and Borom, 1965;Singh et al, 1980;Staff and Grover, 1936;Welch et al, 1941). S. enteritidis is transmitted from infected rats to other rats (Welch et al, 1941) and from infected mice to other mice (Bartram et al, 1940;Shimi et al, 1979). Mice and rats have been implicated in the transmission of Salmonella to poultry (Davies and Wray, 1995;Henzler and Opitz, 1992; National Academy of Sciences, 1969) and to sheep (Hunter et al, 1976).…”

Section: Biological Hazards: Contributing Factorsmentioning

confidence: 99%