Studies on serum 8‐hydroxy guanosine (8‐OHdG) as reliable biomarker for psoriasis

Basavaraj, KH; Devaraju, Panneer; Rao, K. S.

doi:10.1111/j.1468-3083.2011.04441.x

Cited by 28 publications

(31 citation statements)

References 12 publications

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“…Decreased expression of CAT, SOD, and GPx was observed [259–261]. Moreover, mitochondrial damage could be inferred by release of mitochondrial cytochrome c and by upregulated CYP4F8 mRNA [262, 263].…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Pagano

Talamanca

Castello

et al. 2014

Oxidative Medicine and Cellular Longevity

118

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Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involve mitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.

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Section: Autoimmune Diseasesmentioning

confidence: 99%

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Pagano

Talamanca

Castello

et al. 2014

Oxidative Medicine and Cellular Longevity

118

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“…Recent evidence suggests that the redox imbalance found in blood and skin of the patients plays an important role in the pathogenesis of psoriasis. 3 Indeed, numerous studies revealed significantly increased levels of oxidative stress markers such as malondialdehyde (MDA), nitric oxide end products, [3][4][5][6] and 8-OHdG (8-hydroxydeoxyguanosine) 7 in the plasma of psoriatic patients. Likewise, decreased total antioxidant capacity (TAC), vitamin A and E levels, and decreased activity of the main antioxidant enzymes (such as erythrocyte and serum superoxide dismutase and catalase) were also found in the plasma of these patients.…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, decreased total antioxidant capacity (TAC), vitamin A and E levels, and decreased activity of the main antioxidant enzymes (such as erythrocyte and serum superoxide dismutase and catalase) were also found in the plasma of these patients. [3][4][5][6]8 Moreover, the 'severity' of plasma redox imbalance was found to be strongly correlated with the Psoriasis Area and Severity Index (PASI), [4][5][6][7][8] which in turn correlates with the level of inflammatory cytokines. 8 The central role of TNF-α in the pathogenesis of psoriasis has been demonstrated by the clinical efficacy of TNF-α antagonists.…”

Section: Introductionmentioning

confidence: 99%

Altered redox status in the blood of psoriatic patients: involvement of NADPH oxidase and role of anti-TNF-α therapy

et al. 2013

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Background: Psoriasis is a chronic hyperproliferative inflammatory skin disease, characterized by a generalized redox imbalance. Anti-tumor necrosis factor (TNF)-α therapy is widely used for the treatment of this disease, but its effect on blood redox status hasn't been explored. Objective: To investigate the effects of anti-TNF-α therapy on blood redox status in psoriatic patients. Methods: Twenty-nine psoriatic patients (PSO) were divided into two groups: one remained untreated (NRT) and to another the anti-TNF-α therapy was prescribed (TR). The levels of main oxidative stress markers and total antioxidant capacity (TAC) in plasma, levels of total reactive oxygen species (ROS) production, lipoperoxidation, TAC, glutathione content, and activity of NADPH oxidase in white blood cells (WBC) were evaluated in PSO, in NTR and TR after 6 months of the study. Results: Plasma levels of malondialdehyde (MDA) and protein carbonyl content (PCO), ROS production, lipoperoxidation, and glutathione content in WBC were increased, while TAC in both plasma and WBC was decreased in PSO with respect to controls. In the plasma of TR, levels of MDA and PCO were significantly lower with respect to PSO and NTR. The activity of NADPH oxidase was significantly increased in WBC of PSO and NTR but not in TR versus controls. Discussion: Our results represent novel data about the redox status of WBC in psoriatic patients. A significant redox-balancing effect of anti-TNF-α therapy, probably associated with the normalization of NADPH oxidase activity in WBC, was demonstrated.

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“…Numerous biomarker investigations were performed in psoriasis. Serum 8‐hydroxy‐2‐deoxyguanosine (8‐OHdG) was proposed as a biomarker for the early diagnosis, and serum human beta‐defensin (HBD‐2), but not TNF‐like ligand 1A (TL1A), was reported to be a useful marker for disease activity . Plasma levels of transforming growth factor (TGF)‐beta1, tissue inhibitors of metalloproteinases (TIMP)‐1, matrix metalloproteinase (MMP)‐1 and interleukin (IL)‐18 were found to be associated with psoriasis severity and treatment efficacy .…”

Section: Biomarkers and Personalized Medicine In The Dermatological Pmentioning

confidence: 99%

Biomarkers and personalized medicine: current status and further perspectives with special focus on dermatology

Landeck

Kneip

Reischl

et al. 2016

Experimental Dermatology

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Biomarkers are of increasingly high importance in medicine, particularly in the realm of 'personalized medicine'. They are valuable for predicting prognosis and dose selection. Moreover, they may be helpful in detecting therapeutic and adverse responses and in patient stratification based on efficacy or safety prediction. Thus, biomarkers are essential tools for the selection of appropriate patients for treatment with certain drugs to and enable personalized medicine, that is 'providing the right treatment to the right patient, at the right dose at the right time'. Currently, there are six drugs approved for dermatological indications with recommended or mandatory biomarker testing. Most of them are used to treat melanoma and human immunodeficiency virus infection. In contrast to the few fully validated biomarkers, many exploratory biomarkers and biomarker candidates have potential applications. Prognostic biomarkers are of particular significance for malignant conditions. Similarly, diagnostic biomarkers are important in autoimmune diseases. Disease severity biomarkers are helpful tools in the treatment for inflammatory skin diseases. Identification, qualification and implementation of the different kinds of biomarkers are challenging and frequently necessitate collaborative efforts. This is particularly true for stratification biomarkers that require a companion diagnostic marker that is co-developed with a certain drug. In this article general definitions and requirements for biomarkers as well as for the impact of biomarkers in dermatology are reviewed and opportunities and challenges are discussed.

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Studies on serum 8‐hydroxy guanosine (8‐OHdG) as reliable biomarker for psoriasis

Abstract: Serum 8-OHdG levels could be used as good biomarker for the early diagnosis of psoriasis and its management.

Cited by 28 publications

References 12 publications

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Altered redox status in the blood of psoriatic patients: involvement of NADPH oxidase and role of anti-TNF-α therapy

Biomarkers and personalized medicine: current status and further perspectives with special focus on dermatology

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