Studies on serum immunoreactive elastase in experimental pancreatitis rats I. in acute pancreatitis

Two types of experimental chronic pancreatic damage were induced in rats by a copper-deficient diet containing D-penicillamine (DP rats) and by a similar diet without D-penicillamine (D rats). At 5-6 weeks after commencement of treatment, serum copper levels showed a significant decrease in both DP rats (1.5 +/- 0.9 micrograms/dl, M +/- SE) and D rats (18.8 +/- 1.4 micrograms/dl) compared with the findings in control rats (111.8 +/- 4.4 micrograms/dl). Histology revealed loss and atrophy of acinar cells in DP rats and mild vacuolar degeneration of acinar cells in D rats, whereas the islets of Langerhans were intact in both groups. The secretion of the exocrine pancreas showed a marked decrease in enzymes and protein output in DP and D rats compared with findings in the control rats. Our study confirmed the relationships between serum copper levels and morphological damage of pancreatic acinar cells or the reduction of enzyme secretion. On the other hand, the reductions in volume and bicarbonate output of pancreatic juice in DP rats and in D rats were detected, but no relationship was found between these reductions and the serum copper levels. The endocrine pancreatic function in DP rats showed a slight disturbance in intravenous glucose tolerance test. These results support the conclusion that copper-deficiency causes disturbances in enzyme-synthesis and selective destruction of acinar cells.

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Comparison of somatostatin distribution in pancreatic duct ligated rats and streptozotocin diabetic rats

Lee

Wakasugi

Itoh

1983

Gastroenterol Jpn

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The somatostatin content in the pancreas and gastrointestinal tract was examined in normal, streptozotocin (STZ)-diabetic and pancreatic duct ligation (PDL) rats. The somatostatin content in the pancreas and gastric antrum in the STZ-diabetic group showed a higher concentration compared with those in the normal control group (p less than 0.001). The somatostatin content in the duodenum in the PDL group showed a higher concentration compared with those in the sham-operated group (p less than 0.02). There was no significant increase in the lower gastrointestinal tract in the normal, STZ and PDL groups. These facts suggest that the concentration of somatostatin varies according to tissues and organs and that the distribution of somatostatin in chronic pancreatic injury caused by PDL is different from that in diabetes mellitus cases or controls.

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Studies on serum immunoreactive elastase in experimental pancreatitis rats I. in acute pancreatitis

Cited by 3 publications

References 13 publications

Controversies in the Biological Diagnosis of Acute Pancreatitis

Controversies in the Biological Diagnosis of Acute Pancreatitis

Morphological and biochemical changes in the pancreas of copper-deficient rats

Comparison of somatostatin distribution in pancreatic duct ligated rats and streptozotocin diabetic rats

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