Studies on swelling behaviour of radiolytically synthesised PVA/gelatin hydrogels

Swaroop, K.; Gaana, M. J.; Shruthi, S. S.; Shrinidhi,; Shrikant, L. P.; Vinayak, A.; Somashekarappa, H.M.

doi:10.1063/1.5112889

Cited by 4 publications

(2 citation statements)

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“…About 5 ml of the PVA-gelatin mixture solution was put into a series of vial containing 10, 20, and 30 mg of metformin, homogenized with a hand shaker. Subsequently the mixture was frezeed-thawed for 3 cycles (4 °C, 16 hours and 35 °C, 8 hours) and finally irradiated with gamma rays at a single dose of 25 kGy [26,27]. After irradiation, the vials were broken and the hydrogel were removed from within.…”

Section: Immobilization Of Metformin Hcl In Pvagelatin Hydrogelsmentioning

confidence: 99%

“…Drug immobilization method in hydrogel matrix using gamma irradiation technique has advantages such as polymers or monomers as hydrogel matrix can undergo crosslinking reactions, drugs can be trapped in hydrogel matrix simultaneously, there is no need for crosslinkers, and the resulting products are sterile. Based on the previous study, PVA-gelatin hydrogels exhibited the best swelling through gamma rays irradiation at a single dose of 25 kGy [26,27]. In addition, to ensure that the drug does not degrade, the use of PVA as a matrix can be supported with the freeze-thaw process before the irradiation process in the drug-polymer solution mixture.…”

Section: Introduction mentioning

confidence: 99%

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In Vitro Release of Metformin HCl from Polyvinyl Alcohol (PVA) - Gelatin Hydrogels Prepared by Gamma Irradiation

Hariyanti

Erizal²,

Mustikarani

et al. 2022

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The aim of this present work is to use polyvinyl alcohol (PVA)gelatin-based hydrogel prepared by γ-rays irradiation with different gelatin concentrations ranging from 0.5 -2 %w/v for immobilization of Metformin HCl (MH) at dose range of 0 -30 mg. The mixture were freezed-thawed for 3 cycles, irradiated using γ-rays with sterilization dose at 25 kGy (dose rates 5 kGy/h). Gel fraction and water absorption were determined gravimetrically. The surface morphology of hydrogels were observed using Scanning Electron Microscope (SEM). In vitro release of MH were taken using UV-Vis spectrophotometer. After evaluated, it was found that with increasing gelatin concentrations, gel fraction increases and water absorption decreases. With increasing gelatin concentration and drug dosage, the cumulative drug released decreases. From SEM observation, the hydrogel had a heterogeneous porous. The hydrogel based on PVA-gelatin can be considered as a matrix for controlled drug release and safe for humans since both PVA and gelatin are non-toxic.

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Section: Immobilization Of Metformin Hcl In Pvagelatin Hydrogelsmentioning

confidence: 99%

Section: Introduction mentioning

confidence: 99%