Studies on Synthesis and Biological Activity of Oxidative Aglafolin Derivatives

Abstract

in Wiley Online Library (wileyonlinelibrary.com).The synthesis of the key intermediate of rocaglamide, oxidative aglafolin, was studied, and its diastereoisomers were obtained. The amination of oxidative aglafolin was also investigated, affording amino derivatives. The preliminary bioassay results indicate that these new aglafolin derivatives showed certain degree of insecticidal and repellent activity against Plutella xylostella and Laphygma exigua.

Synthesis of cis-Oriented Vicinal Diphenylethylenes through a Lewis Acid-Promoted Annulation of Oxotriphenylhexanoates

“…However, there are only a limited number of general methods for direct stereoselective formation of cyclic compounds possessing the cis-vic -diphenylethylene moiety. It is also worth noting that a majority of these syntheses are devoted to the diphenyl dihydrobenzofuran moiety found in the rocaglates. ,,,,− …”