Studies on the animal model of traumatic pseudoaneurysm

Abstract

Sixty-nine cases of pseudoaneurysm were made in 72 femoral arteries of 54 Japanese white rabbits, with a successful rate of 95.8%. Colored Doppler's ultrasonic imaging, CT, MRI, arterial angiography, anatomic dissection, and histologic observation were carried out at different times after the operation. The mechanism for the formation of pseudoaneurysm was discussed and the effects of colored Doppler's ultrasonic imaging, CT, MRI, and arterial angiography in the diagnosis of pseudoaneurysm were evaluated.

Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty

“…Pseudoaneurysm formation in humans is not rare after vascular surgery; although pseudoaneurysms are less common in modern practice compared with earlier decades, pseudoaneurysms continue to present as a late complication in 1% to 5% of cases. 20, 10 Although there are several animal models of true aneurysms, there has been no small animal model of pseudoaneurysm reported that reliably recapitulates human pseudoaneurysms; a rabbit model of traumatic pseudoaneurysm, 21, 21 as well as pig models of arteriovenous graft and femoral pseudoaneurysm, 22, 23 have been reported. Our small animal model of pseudoaneurysms is easily created with basic microsurgical skills and reliably creates pseudoaneurysms (Figure 1); since patch angioplasty is used clinically to prevent restenosis, it is not surprising that we also did not detect any restenosis in this model.…”