Studies on the anti-diabetic and hypolipidemic potentials of mangiferin (Xanthone Glucoside) in streptozotocin-induced Type 1 and Type 2 diabetic model rats.

Dineshkumar, B.; Mitra, Analava; Manjunatha, M.

doi:10.5138/ijaps.2010.0976.1055.01009

Cited by 33 publications

(7 citation statements)

References 24 publications

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“…Bioactive compound, mangiferin (MGF), mostly found in the leaves is reported to have alpha amylase and alpha glucosidase inhibitory effects [85]. Furthermore, mangiferin is reported to have antidiabetic as well as hypolipidemic potential effects in type-2-diabetic model rats.…”

Section: Resultsmentioning

confidence: 99%

Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence

Adinortey

Agbeko

Boison

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Available data indicate that diabetes mellitus leads to elevated cost of healthcare. This imposes a huge economic burden on households, societies, and nations. As a result many Ghanaians, especially rural folks, resort to the use of phytomedicine, which is relatively less expensive. This paper aims at obtaining information on plants used in Ghana to treat diabetes mellitus, gather and present evidence-based data available to support their uses and their mechanisms of action, and identify areas for future research. Method. A catalogue of published textbooks, monographs, theses, and peer-reviewed articles of plants used in Ghanaian traditional medicine between 1987 and July 2018 for managing diabetes mellitus was obtained and used. Results. The review identified 76 plant species belonging to 45 families that are used to manage diabetes mellitus. Leaves were the part of the plants frequently used for most preparation (63.8%) and were mostly used as decoctions. Majority of the plants belonged to the Euphorbiaceae, Lamiaceae, Asteraceae, and Apocynaceae families. Pharmacological data were available on 23 species that have undergone in vitro studies. Forty species have been studied using in vivo animal models. Only twelve plants and their bioactive compounds were found with data on both preclinical and clinical studies. The records further indicate that medicinal plants showing antidiabetic effects did so via biochemical mechanisms such as restitution of pancreatic β-cell function, improvement in insulin sensitivity by receptors, stimulating rate of insulin secretion, inhibition of liver gluconeogenesis, enhanced glucose absorption, and inhibition of G-6-Pase, α-amylase, and α-glucosidase activities. Conclusion. This review contains information on medicinal plants used to manage diabetes mellitus, including their pharmacological properties and mechanisms of action as well as models used to investigate them. It also provides gaps that can form the basis for further investigations and development into useful medications for effective treatment of diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence

Adinortey

Agbeko

Boison

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…: 204–206 °C) [30], homomangiferin C 20 H 20 O 11 ( 6 , m/z 436, m.p. : 249–251 °C) [31] and mangiferin C 19 H 18 O 11 (7, m/z 422, m.p. : 259–260 °C) [32], from A. adianthifolia roots extract, were determined using physical and NMR ( 1 H, 13 C and 2D) data, in comparison with those of related compounds in the literature (Additional file 1).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria

Tchinda

Sonfack

Simo

et al. 2019

BMC Complement Altern Med

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Background Albizia adianthifolia (Schum.) is medicinally used in Cameroon to manage bronchitis and skin diseases. Our previous study documented the antibacterial potential of its roots’ methanol extract. In this study, methanol roots extract was subjected to chromatography techniques and fractions (AARa and AARb), sub-fractions (AARa1–4, AARb1–2 and AARb11–14) together with isolated phytochemicals were assessed for their antimicrobial as well as their antibiotic-potentiating effects towards Gram-negative multidrug resistant (MDR) bacteria. Methods The antibacterial activities of the samples (determination of Minimal Inhibitory « MIC » and Minimal Bactericidal Concentration « MBC ») were determined by the modified rapid p-iodonitrotetrazolium chloride (INT) colorimetric assay, as well as those of antibiotics in association with the compounds. Column chromatography was applied to isolate phytochemicals from roots extract and their chemical structures were determined using spectroscopic techniques. Results The phytochemicals isolated were stearic acid ( 1 ), a mixture (1:1) of stigmasterol and β -sitosterol ( 2 + 3 ), β -sitosterol 3- O - β - D -glucopyranoside ( 4 ), palmatin ( 5 ), homomangiferin ( 6 ) and mangiferin ( 7 ). Fraction AARa exhibited selective inhibitory effects whilst all tested bacteria were inhibited by AARb in MIC ranges of 8 to 1024 μg/mL. Sub-fractions AARb1–2 had MIC values between 8 μg/mL and 1024 μg/mL on all tested bacteria. Phytochemicals 4, 2 + 3 and 7 inhibited the growth of 54.54% (6/11), 45.45% (5/11) and 27.27% (3/11) tested bacterial strains, respectively. When tested with an efflux pumps inhibitor (Phenylalanine-Arginine- β -Naphthylamide or PAβN), the inhibitory effects of compounds 2 + 3 and 4 increased towards all the tested bacteria. In association with erythromycin (ERY), streptomycin (STR) and tetracycline (TET), compounds 2 + 3 and 4 had the most significant synergistic activity on the seven selected bacteria. Conclusion The present study provides information on the possible use of Albizia adianthifolia and its constituents in the control of Gram-negative infections including MDR phenotypes. Electronic supplementary material The online version of this article (10.1186/s12906-019-2537-1) contains supplementary material, which is available to authorized users.

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“…The dried leaves were then blended and sieved with a B40 sieve to obtain Coffea arabica L. leaves powder with a uniform size. For sample extraction, 225 mg Coffea arabica L. leaves powder was extracted with petroleum ether (2 x 2 L, 6 h each time) to remove fatty matter, with cold acetone (4 x 2 L, 24 h each time) to remove tannins and finally with 70% ethanolic solvent (4 x 1 L, 6 h each time) (18). For sample preparation, 72 mg extract was diluted with 10 mL methanol and filtered with Whatman filter paper no.40.…”

Section: 1mentioning

confidence: 99%

A Densitometric Method for Determination of Mangiferin, an Antioxidant Compound, with Thin Layer Chromatography in the Leaf Extracts of Coffee (Coffea Arabica L.)

RETNANİNGTYAS,

PUTRİ NARİNDRA,

KRİSTİNİNGRUM

2024

Journal of the Turkish Chemical Society Section A: Chemistry

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Mangiferin is one of the antioxidants in Coffea arabica L. leaves that has many pharmacological effects. The content of secondary metabolites in the leaves including mangiferin can be affected by age. A Thin Layer Chromatography (TLC) method for the quantitative analysis of mangiferin in Coffea arabica L. leaves extract was developed and validated. The method was developed using a mobile phase prepared with analytical grade solvents: ethyl acetate, methanol, formic acid, and deionized water (8:2:1:1 v/v/v/v). Regression functions were established over the 199.98-600.00 ng/spot range with r=0.999. The limit of detection (LOD) and limit of quantification (LOQ) were 13.87 and 41.61 ng, respectively. The method was selective with a resolution value of more than 1.5 and specific with the spectra correlation value for purity and identity check of more than 0.99. The percentage RSD was found to be 2.43% for repeatability precision and 2.05% for intermediate precision. The method's accuracy was determined through the standard addition method by adding known quantities of standard mangiferin to the pre-analyzed test solution and the mean recovery was 101.69± 1,21%. This TLC Densitometry method was linear, sensitive, selective and specific, precise, accurate, and can be used for routine analysis of mangiferin. On the young Coffea arabica L. leaves, the concentration of mangiferin ± RSD was 0.830 ± 1.71% w/w, and on the old Coffea arabica L. leaves was 1.128± 1.59% w/w.

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Studies on the anti-diabetic and hypolipidemic potentials of mangiferin (Xanthone Glucoside) in streptozotocin-induced Type 1 and Type 2 diabetic model rats.

Cited by 33 publications

References 24 publications

Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence

Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence

Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria

A Densitometric Method for Determination of Mangiferin, an Antioxidant Compound, with Thin Layer Chromatography in the Leaf Extracts of Coffee (Coffea Arabica L.)

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