Studies on the anti-inflammatory and anti-nociceptive properties of Blepharis maderaspatensis leaves

Sowemimo, Abimbola; Onakoya, Monsurat; Fageyinbo, Muyiwa Samuel; Fadoju, Titilayo

doi:10.1590/s0102-695x2013000500016

Cited by 35 publications

(22 citation statements)

References 23 publications

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“…The curative properties of Blepharis species paved the way for researchers to explore their therapeutic properties. Herein, several pharmacological properties for other plant species from the genus Blepharis have been reported, such as anti-inflammatory and anti-nociceptive properties [6], wound healing activities [7], and gastroprotective [8] effects of B. maderaspatensis (L.) B.Heyne ex Roth. Moreover, other studies reported antioxidant activity for B. maderaspatensis and B. molluginifolia Pers.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

et al. 2019

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Background: Blepharis linariifolia Pers. (Family: Acanthaceae) is used in traditional medicines as a general tonic and for the treatment of various health problems in Sudan. The main aim of this study was to isolate and identify the major chemical constituents from the aerial parts of B. linariifolia and evaluate their bioactivities. Methods: The dried aerial parts of the plant were extracted successively with 100% acetone and 50% acetone, and thereafter the combined extract was subjected to repeated column chromatography to isolate the main components. Free radical scavenging activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical method, and in vitro enzyme inhibitory activities against α-glucosidase, pancreatic lipase, and mushroom tyrosinase were evaluated. Results: From the detailed chemical analysis, verbascoside (1), vanillic acid (2), apigenin (3), and 6″-O-p-coumaroylprunin (4), were isolated and their structures were identified on the basis of their nuclear magnetic resonance (NMR) spectral data. Among the isolated compounds, verbascoside (1) showed the most potent free radical scavenging activity (IC50 = 22.03 ± 0.04 μM). Apigenin (3) and 6″-O-p-coumaroylprunin (4) showed promising inhibitory activities against all tested enzymes. Apigenin (3) showed the most potent inhibitory activity against α-glucosidase and tyrosinase (IC50 = 34.73 ± 1.78 μM and 23.14 ± 1.83 μM, respectively), whereas 6″-O-p-coumaroylprunin (4) showed potent inhibition for lipase (IC50 = 2.25 ± 0.17 μM). Conclusions: Four phenolic compounds were isolated and identified from B. linariifolia acetone extract, which are reported for the first time from this plant. All compounds showed good DPPH free radical scavenging activities, with verbascoside (1) being the most potent. Apigenin (3) was the most active as α-glucosidase and mushroom tyrosinase inhibitor, while 6″-O-p-coumaroylprunin (4) showed potent inhibitory activity for pancreatic lipase.

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Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

et al. 2019

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“…These mediators are responsible for edema as they enhance vascular permeability and improve vasodilation [56]. Fluid accumulation occurs at the treatment site, which is shown by the xylene-induced ear edema test and inhibition of this fluid accumulation is considered as anti-inflammatory effect [57]. Topical steroids or nonsteroidal anti-inflammatory agents inhibit phospholipase A2 which can be evaluated by the xylene-induced ear edema test [37].…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti‐Inflammatory Activities of Diethyl Ether and n‐Hexane Extract of Polyalthia suberosa Leaves

Yasmen

Aziz

Tajmim

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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In folk medicine, Polyalthia suberosa is used as abortifacient, laxative, febrifuge analgesic, filler of tooth cavities, and anti-HIV drug and for rheumatism and various skin infections. The present study was directed to evaluate the analgesic and anti-inflammatory activities of diethyl ether and n-hexane extracts of Polyalthia suberosa leaves (PSDE and PSNH). A variety of tests including formalin-induced paw licking test, acetic acid induced writhing test, and tail immersion test were used to assess the analgesic activity. In addition, xylene-induced ear edema test was used to evaluate anti-inflammatory activity of PSDE and PSNH. PSDE and PSNH at 200 and 400 mg/kg doses expressed analgesic as well as anti-inflammatory activities in mice. In formalin-induced paw licking test, acetic acid induced writhing test, and xylene-induced ear edema test, the extracts exhibited significant inhibition (⁎P < 0.05 versus control) of pain and inflammation. Alternatively, in tail immersion test, PSDE 400 mg/kg showed significant (⁎P < 0.05 versus control) latency at 30 min but another tested sample had no significant latency. From this study, it could be shown that Polyalthia suberosa leaves may contain analgesic and anti-inflammatory agents which support its use in traditional medicine.

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“…Inflammation is a complex physiological response of living tissues to injury and is known to involve a complex array of enzymes' activation, mediators' release, extravasations of fluid, cell migration, tissue breakdown, and repair [32]. In this respect, protein's denaturation is also pointed as a central cause of inflammation [33].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…Two hours after the application of xylene, the rats were sacrificed using chloroform anesthesia and both ears were removed. Circular sections (6 mm diameter) of both the right (treated) and left (untreated) ears were sampled with a punch and weighted [32]. The edematous response was measured as the weight difference between the right and left ears, where the inhibition level was calculated according to the following equation:…”

Section: Xylene-induced Ear Edemamentioning

confidence: 99%

Scrophularia Tenuipes Coss and Durieu: Phytochemical Composition and Biological Activities

et al. 2020

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Scrophularia tenuipes is an Algerian-Tunisian endemic species, which has not been studied yet. Ethyl acetate (EA) and n-butanol (Bu) fractions obtained from Scrophularia tenuipes were investigated for their health benefit properties, in particular with respect to in vivo/in vitro anti-inflammatory and antioxidant activities, as well as their potential to inhibit key enzymes with impact in diabetes (α-glucosidase and α-amylase). The fractions had a distinct phytochemical composition, of which EA was richer in total phenolic compounds (225 mg GAE/g) and mostly composed of the phenylethanoid acetyl martynoside. Compared to EA, Bu had higher amounts of total flavonoids, and according to the result obtained from UHPLC-DAD-ESI-MSn analysis, harpagoside (iridoid) was its major phytochemical. EA fraction was quite promising with regard to the in vivo (at 200 mg/kg, po) anti-inflammatory effect (62% and 52% for carrageenan-induced rat paw edema and xylene-induced ear edema tests, respectively), while Bu fraction exhibited a stronger antioxidant capacity in all tests (IC50 = 68 µg/mL, IC50 = 18 µg/mL, IC50 = 18 µg/mL and A0.50 = 43 µg/mL for DPPH●, ABTS•+, O2•− scavenging assays and cupric-reducing antioxidant capacity method, respectively). Both fractions also showed a strong effect against α-amylase enzyme (IC50 = 8 µg/mL and 10 µg/mL for EA and Bu fraction, respectively).

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Studies on the anti-inflammatory and anti-nociceptive properties of Blepharis maderaspatensis leaves

Cited by 35 publications

References 23 publications

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

Analgesic and Anti‐Inflammatory Activities of Diethyl Ether and n‐Hexane Extract of Polyalthia suberosa Leaves

Scrophularia Tenuipes Coss and Durieu: Phytochemical Composition and Biological Activities

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