Studies on the Anti-Inflammatory and Anti-Nociceptive Effects of Melatonin in the Rat

El‐Shenawy, Siham M.; Abdel-Salam, Omar M.E.; Baiuomy, Ayman R.; El-Batran, Siham; Arbid, Mahmoud S.

doi:10.1016/s1043-6618(02)00094-4

Cited by 128 publications

(91 citation statements)

References 39 publications

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“…Inhibition of any of these mediators may lead to antipyresis (El-Shenawy et al, 2002). The reliable nature of the anti-inflammatory mechanisms of flavonoids and alkaloids from EECB has not been clarified, but the present study's results were confirmed from the popular use of this plant in the treatment of inflammatory diseases.…”

Section: Discussionsupporting

confidence: 48%

Chemical composition and anti-inflammatory effects of the EtOAc extract from Capsella bursa-pastoris (L.) Medic.

Wang¹,

Bai-yin-mu-qi-er²,

Agula³

2017

Afr. J. Pharm. Pharmacol.

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The aerial parts of Capsella bursa-pastoris (L.) Medic are used to treat nephritis, edema and enteritis. Every barber knows that C. bursa-pastoris had a good anti-inflammatory effect. This suggests that the extracted components from C. bursa-pastoris could potentially treat inflammatory disease. For discovering of the anti-inflammatory effects and chemical composition of C. bursa-pastoris, EtOAc extract was extracted from C. bursa-pastoris (EECB) and researched on EECB's anti-inflammatory effects. On the carrageenan-induced paw oedema experiment, the EECB used at the doses (100, 200 and 300 mg/kg) after 10 h (p < 0.01), 5 h (p < 0.01) and 3 h (p < 0.01), respectively, showed significant anti-inflammatory effects. Moreover, on the egg-albumin-induced inflammation experiment, the EECB used at the doses 200 and 300 mg/kg after 4 h (p < 0.01) and 2 h (p < 0.01), respectively, showed significant anti-inflammatory effects. In accordance with the HPLC isolation of the EECB, there are four major compounds, namely, apigenin-7-O-β-D-glucopyranoside (S1), luteolin-7-O-β-Dglucopyranoside (S2), α-adenosine (S3), and uridine (S4), which may explain the activity.

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Section: Discussionsupporting

confidence: 48%

Chemical composition and anti-inflammatory effects of the EtOAc extract from Capsella bursa-pastoris (L.) Medic.

Wang¹,

Bai-yin-mu-qi-er²,

Agula³

2017

Afr. J. Pharm. Pharmacol.

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“…Melatonin is a hormone secreted by the pineal gland, which regulates important biological functions including circadian rhythms, sleep, and mood (Sugden, 1983;Morgan et al, 1994;Vanecek, 1998;Szymanska et al, 2001;El-Shenawy et al, 2002;von Gall et al, 2002;Zahn et al, 2003;Pandi-Perumal et al, 2006). Melatonin receptors are located in the spinal cord and various brain regions (Vitte et al, 1990;Stankov et al, 1991;Morgan et al, 1994;Zahn et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, melatonin (5-methoxy-N-acetyltryptamine), a pineal neurohormone and a derivative of serotonin, may be critically involved in the regulation of both mood and pain (Sugden, 1983;El-Shenawy et al, 2002). It has been shown that melatonin receptor type 1 (MT1)-knockout mice displayed depression-like behavior with altered sensory responses and attention deficits (Weil et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Exacerbated mechanical allodynia in rats with depression-like behavior

et al. 2008

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Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of depressionlike behavior in WKY rats. Moreover, there was a lower plasma melatonin concentration and a lower melatonin receptor expression in the anterior cingular cortex in WKY rats than in Wistar rats. These results suggest that there exists a reciprocal relationship between mechanical allodynia and depression-like behavior and the melotoninergic system in the anterior cingular cortex might play an important role in the interaction between pain and depression.

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“…To assess the anti-inflammatory activity, Dazzle capsules was evaluated by popular screening model widely used for NSAID namely Carrageenan induced rat paw oedema. 18 It shows a biphasic effect. 19 The first phase is due to release of histamine and serotonin (5-HT) (0-2 hrs), plateau phase is maintained by kinin like substance (3 hrs) and second accelerating phase of swelling is attributed to Prostaglandin release (4 hrs).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Polyherbal Formulation for Anti-Inflammatory Activity in Carrageenan Induced Paw Oedema Model in Rats

Bhatt¹,

Soni²,

Shah³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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Dazzle Capsule, a Poly herbal formulation is marketed in management of Arthritis and joint-musculo skeletal pain. In this study, safety and efficacy of this polyherbal formulation was investigated in which it was being proved safe for use via acute toxicity study and efficacy was being evaluated by carrageenan-induced rat paw oedema test in rats in order to explore its anti-inflammatory activity at the dose level of 90 and 180 mg/kg, p.o, compared with Indomethacin (10 mg/kg, p.o.). It showed an highly significant reduction in oedema (p<0.001). Indomethacin inhibited oedema by 30.054% and 36.216% at 2 and 3 hr after carrageenan injection, respectively. The inhibitory effect of Dazzle Capsule began at 2 hr or later after carrageenan injection depending upon the administered dose. Low doses of Dazzle Capsule (90 mg/kg) gave highly significant inhibitory effects of 37.894-39.378%, and higher doses (180 mg/kg) caused highly significant inhibition of 19.125-30%. The reduction of oedema by Indomethacin and Dazzle Capsule at 2 hr or more after carrageenan injection suggested that both compounds produce anti-inflammatory effects in the second phase of oedema, indicating inhibition of prostaglandin synthesis. Hence, it was concluded that, Dazzle Capsule is having potent anti-inflammatory activity yet safe polyherbal formulation for use in arthritis management.

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Studies on the Anti-Inflammatory and Anti-Nociceptive Effects of Melatonin in the Rat

Cited by 128 publications

References 39 publications

Chemical composition and anti-inflammatory effects of the EtOAc extract from Capsella bursa-pastoris (L.) Medic.

Chemical composition and anti-inflammatory effects of the EtOAc extract from Capsella bursa-pastoris (L.) Medic.

Exacerbated mechanical allodynia in rats with depression-like behavior

Evaluation of Polyherbal Formulation for Anti-Inflammatory Activity in Carrageenan Induced Paw Oedema Model in Rats

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