Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

Abstract

trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.

Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by Trans-cinnamaldehyde in C2C12 Myoblasts

“…Trans-cinnamaldehyde (tCA) is one of the major phytochemical constituents isolated from the stem bark of Cinnamomum cassia (L.) J. Presl (Cinnamon), which is frequently used in traditional medicine for the prevention and treatment of various diseases such as ischemia, anxiety, arrhythmia, indigestion, diabetes, gastritis, blood circulation disorders, and so on [18][19][20]. A number of previous studies have shown that tCA has a variety of beneficial pharmacological effects, including anti-inflammatory, antioxidant, anti-diabetic, anti-obesity, neuroprotective, and anti-tumor effects in a number of in vitro and in vivo models [21][22][23][24][25][26][27].…”

Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum

“…There are few studies including these compounds and interactions with the NO/cGMP system. Davaatseren et al (18) recently reported that trans-cinnamaldehyde, an active compound of cinnamon did not affect the production of NO. In addition, the relaxation response to CA in rat aorta and porcine coronary artery did not alter in the presence of NOS and sGC inhibitors (19, 20).…”

Thermal Degradation of Linalool-Chemotype Cinnamomum osmophloeum Leaf Essential Oil and Its Stabilization by Microencapsulation with β-Cyclodextrin

“…Natural products from cinnamon plants ( Cinnamomum spp., Lauraceae) exhibit various bioactivities, such as antimicrobial, insecticidal, anti-inflammatory, antidiabetic activities and, etc. [ 1 , 2 , 3 , 4 , 5 ]. Cinnamomum osmophloeum Kanehira is commonly used as folk medicines and food flavors.…”