Studies on the Bactericidal Properties of the Synovial Fluid 1

Gara, Paul F. de

doi:10.1172/jci101374

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…A lack of positive culture does not mean the synovial structure is not infected (Morris 1980;Orsini 1984) and this has also been described in human studies of septic synovitis where clinical signs and cytology, other than bacteriology, are insignificantly different between culture positive and culture negative patients. The reported success rate for a positive culture from synovial fluid is highly variable (Lavoie et al 1991;Madison et al 1991;Honnas et al 1992;Schneider et al 1992) and it is recognised that culture of synovial fluid is difficult because of a number of potential factors, such as the sequestration of the bacterium into the synovial membrane (McIlwraith 1983) and the bactericidal qualities of the synovial fluid (DeGara 1943;Gruber et al 2008).…”

Section: Discussionmentioning

confidence: 99%

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Bacterial culture of septic synovial structures of horses: Does a positive bacterial culture influence prognosis?

Taylor¹,

Mair

Smith

et al. 2010

Equine Veterinary Journal

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Fourteen (20.9%) of 67 horses with a positive bacterial culture from synovial fluid were subjected to euthanasia because of persistent synovial sepsis compared to 2 (1.44%) of 139 with negative bacterial cultures (P<0.001). Overall survival and successful long-term return to function in horses with a positive bacterial culture was 50% (24/48 horses) compared to 70.5% (74/105) in culture negative horses (P=0.01). In horses that survived to be discharged, successful long-term return to function was not significantly different between culture positive and culture negative groups. Growth of Staphylococcus aureus from synovial fluid did not affect short-term survival to discharge from the hospital compared to other positive bacterial culture; however, successful long-term return to function was only 30.4% (4/13) in horses from which S. aureus was cultured compared to 73.9% (17/23) of horses in which other bacteria were cultured (P=0.015). CONCLUSIONS AND POTENTIAL CLINICAL RELEVANCE: Horses with a positive bacterial culture from a septic synovitis have a poorer prognosis for survival to discharge from hospital and overall long-term return to function than horses that yielded no bacterial growth. When S. aureus was cultured, the long-term prognosis was poorer.

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Section: Discussionmentioning

confidence: 99%

“…1992; Schneider et al. 1992) and it is recognised that culture of synovial fluid is difficult because of a number of potential factors, such as the sequestration of the bacterium into the synovial membrane (McIlwraith 1983) and the bactericidal qualities of the synovial fluid (DeGara 1943; Gruber et al. 2008).…”

Section: Discussionmentioning

confidence: 99%

Bacterial culture of septic synovial structures of horses: Does a positive bacterial culture influence prognosis?

Taylor¹,

Mair

Smith

et al. 2010

Equine Veterinary Journal

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“…The regime should be changed, if indicated by the results of these tests. Synovial culture is often negative because of prior antibiotic use, collection and laboratory error, confinement of the purulent process to bone (Murray and Jacobson 1971) or to the synovial or fibrous layers of the joint capsule (Coggeshall, Bennett, Warren and Bauer 1941), the bacteriocidal properties of synovia (DeGava 1943) or the role of other types of microorganism (McChesney, Becerra and England 1974; Moorthy, Spradbrow and Eisler 1977).…”

Section: Treatmentmentioning

confidence: 99%

Current concepts of infectious polyarthritis in foals

Firth

1983

Equine Veterinary Journal

122

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Summary Because the majority of foals afflicted with “joint ill” also have infectious (poly)osteomyelitis, previous definitions no longer suffice. In this article the different syndromes are described and classified and the pathogenesis, prognosis and treatment of the disease complex are discussed. Résumé Puisque la majorité des foals souffrant “d'arthrite” ont aussi des (poly) ostéomyélites, les définitions jusqu'a à présent retenues ne conviennent plus. Dans cet article, les différents syndromes sont décrits, classés, et la pathogénèse, le pronostic et le traitement du complexe morbide sont discutés. Zusammenfassung Weil die Mehrheit aller Fohlen mit “joint ill” (annähernd gleich “Fohlenlähme”) auch an infektiöser (Poly)Osteomyelitis leidet, lassen sich die früheren Definitionen nicht länger verwenden. In diesem Artikel werden die verschiedenen Syndrome beschrieben und klassiert. Die Pathogenese, die Prognose und die Behandlung des Krankheitskomplexes werden diskutiert.

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“…Our studies were therefore initiated to ascertain whether complement activity in synovial fluid would reflect more closely the disease process in the articular cavity than do the serum complement levels. De Gara showed that complement is present in synovial fluid (20) …”

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confidence: 99%