Studies on the binding of lipoteichoic acid to osseous tissue

O'Grady, Robert L.; Harrop, P.; Knox, K. W.; Wicken, A. J.

doi:10.1111/j.1600-0765.1980.tb00275.x

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…Other than binding to cells, LTAs from S. mutans strain BHT were found to exhibit high affinity for hydroxyapatite (Ciardi et al, 1977), a feature of LTA that could enhance Gram-positive colonization on dental surfaces. Also, LTA extracts from Enterococcus hirae ATCC 9790 bind to calcified matrix, as well as to cells of neonatal rat parietal and long bones (O'Grady et al, 1980). In a tissue culture study, LTA stimulated bone resorption (Hausmann et al, 1975).…”

Section: Lipoteichoic Acidmentioning

confidence: 99%

Virulence Factors ofEnterococcus faecalis: Relationship to Endodontic Disease

Kayaoğlu

Ørstavik²

2004

Critical Reviews in Oral Biology & Medicine

403

247

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Enterococcus faecalis is a micro-organism that can survive extreme challenges. Its pathogenicity ranges from life-threatening diseases in compromised individuals to less severe conditions, such as infection of obturated root canals with chronic apical periodontitis. In the latter situation, the infecting organisms are partly shielded from the defense mechanisms of the body. In this article, we review the virulence factors of E. faecalis that may be related to endodontic infection and the periradicular inflammatory response. The most-cited virulence factors are aggregation substance, surface adhesins, sex pheromones, lipoteichoic acid, extracellular superoxide production, the lytic enzymes gelatinase and hyaluronidase, and the toxin cytolysin. Each of them may be associated with various stages of an endodontic infection as well as with periapical inflammation. While some products of the bacterium may be directly linked to damage of the periradicular tissues, a large part of the tissue damage is probably mediated by the host response to the bacterium and its products.

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Section: Lipoteichoic Acidmentioning

confidence: 99%

Virulence Factors ofEnterococcus faecalis: Relationship to Endodontic Disease

Kayaoğlu

Ørstavik²

2004

Critical Reviews in Oral Biology & Medicine

403

247

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“…In addition, there is evidence that LTA may play an important role in modulating the defense mechanisms of the host. LTA has been shown to suppress the immune responses and to promote carbon clearance by the reticuloendothelial system in mice (16) and to stimulate the release of lysosomal enzymes by macrophages (20).…”

mentioning

confidence: 99%

Characterization of lipoteichoic acid binding to polymorphonuclear leukocytes of human blood

Courtney¹,

Ofek²,

Simpson³

et al. 1981

Infect Immun

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Preparation of LTA. [3H]LTA (specific activity, 20,000 to 30,000 cpm/,ug) was obtained by growing streptococci in the presence of radiolabeled glycerol as previously described (19). Briefly, group A streptococci, strain 1RP41 (originally obtained from Rebecca Lancefield, The Rockefeller University, New York, N.Y.), were grown in 5-liter batches in van de Rijn-Kessler defined medium (26) containing 2.5 mCi of [2-3H]glycerol (specific activity, 200 mCi/mmol; New England Nuclear Corp., Boston, Mass.) per liter. After 16 h of growth at 370C, the bacteria were harvested

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“…Although there is now some evidence to suggest that osteoclasts can be derived from hemopoietic bone marrow [16][17][18][19], it is unlikely that all the osteoclasts seen histologically could have arisen entirely by the fusion of bloodborne precursors. Of particular interest is a recent study of the binding of:~H-LTA to neonatal rat calvariae in vitro [20], which has shown that LTA reacts with both the hydroxyapatite of the matrix and the bone ceils. It seems possible therefore that in the present model system the stimulus for osteoclast differentiation was provided by antigen binding to the cell membrane of skeletal precursors, probably located within the periosteum and endosteum of the explants.…”

Section: Discussionmentioning

confidence: 99%

Effect of streptococcal cell wall components on bone metabolism in vitro

1982

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Summary. Cell wall components from Streptococcus mutans NCTC 10449 and Streptococcus san-~,uis ATCC 10558 stimulated the release of 4:'Ca from prelabeled mouse calvariae in organ culture. Bone resorbing activity was not blocked by fetal calf serum. It was, however, blocked by calcitonin, an inhibitor of osteoclast-mediated bone resorption. Indomethacin, a prostaglandin synthetase inhibitor, partially blocked endogenous but not antigenstimulated ~:'Ca release, suggesting that antigenstimulated bone resorption was not mediated by prostaglandins. The antigen preparations also had an inhibitory effect on the incorporation of :~H-proline and :~H-thymidine into explants of rabbit and rat calvariae, respectively. The inhibitory effect of antigen on :~H-proline incorporation was not altered by the presence of calcitonin, which suggests that it represented a real inhibition of protein synthesis and not a reflection that the bones were resorbing. These findings indicate that plaque bacterial antigens may contribute directly to the progressive loss of alveolar bone during periodontal disease. The assumption that only Gram-negative organisms play an important role in the etiology of periodontal disease appears incorrect.

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Studies on the binding of lipoteichoic acid to osseous tissue

Cited by 8 publications

References 32 publications

Virulence Factors ofEnterococcus faecalis: Relationship to Endodontic Disease

Virulence Factors ofEnterococcus faecalis: Relationship to Endodontic Disease

Characterization of lipoteichoic acid binding to polymorphonuclear leukocytes of human blood

Effect of streptococcal cell wall components on bone metabolism in vitro

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