Studies on the Bottom-Up and Top-Down Neural Information Flow Alterations in Neurodegeneration

Alipour, Abolfazl; Mozhdehfarahbakhsh, Azadeh; Nouri, Saba; Petramfar, Peyman; Tahamtan, Mahshid; Kamali, Ali-Mohammad; Rao, K. S.; Nami, Mohammad

doi:10.3233/jad-200590

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…In the following two days, mice experienced behavioral shaping that involved running in alternate directions to baited goal arms for 10 minutes. Afterward, mice were subjected to the T-maze training until they met the performance criteria (70% of their trials correctly on two out of three consecutive days) [4,31]. Figure 1A shows the schematic diagram of a single trial of the DNMTP task.…”

Section: Delayed Non-match-to-place Taskmentioning

confidence: 99%

“…Recently, brain networks have gained popularity due to their ability to reflect cognitive processes in the brain [25][26][27][28]. The network analysis approaches (such as Granger causality and directed transfer function) can be used to estimate directed connectivity across different brain regions and to investigate fundamental mechanisms of neurological and mental conditions, and may even be predictive of further explanations of the pathogenesis of neurodegenerative diseases [29][30][31]. Therefore, in this study, we recorded local field potentials (LFPs) from mPFC and MD while the mice (APP/PS1 transgenic model and control) performed a T-maze spatial working memory task.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice

Zhang,

Ai,

Wang

et al. 2024

Journal of Alzheimer’s Disease

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Background: Working memory deficits in Alzheimer’s disease (AD) are linked to impairments in the retrieval of stored memory information. However, research on the mechanism of impaired working memory retrieval in Alzheimer’s disease is still lacking. Objective: The medial prefrontal cortex (mPFC) and mediodorsal thalamus (MD) are involved in memory retrieval. The purpose of this study is to investigate the functional interactions and information transmission between mPFC and MD in the AD model. Methods: We recorded local field potentials from mPFC and MD while the mice (APP/PS1 transgenic model and control) performed a T-maze spatial working memory task. The temporal dynamics of oscillatory activity and bidirectional information flow between mPFC and MD were assessed during the task phases. Results: We mainly found a significant decrease in theta flow from mPFC to MD in APP/PS1 mice during retrieval. Conclusions: Our results indicate an important role of the mPFC-MD input for retrieval and the disrupted information transfer from mPFC to MD may be the underlying mechanism of working memory deficits in APP/PS1 mice.

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Section: Delayed Non-match-to-place Taskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice

Zhang,

Ai,

Wang

et al. 2024

Journal of Alzheimer’s Disease

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A Proposed Brain-, Spine-, and Mental- Health Screening Methodology (NEUROSCREEN) for Healthcare Systems: Position of the Society for Brain Mapping and Therapeutics

Nami

Thatcher

Kashou

et al. 2022

JAD

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The COVID-19 pandemic has accelerated neurological, mental health disorders, and neurocognitive issues. However, there is a lack of inexpensive and efficient brain evaluation and screening systems. As a result, a considerable fraction of patients with neurocognitive or psychobehavioral predicaments either do not get timely diagnosed or fail to receive personalized treatment plans. This is especially true in the elderly populations, wherein only 16% of seniors say they receive regular cognitive evaluations. Therefore, there is a great need for development of an optimized clinical brain screening workflow methodology like what is already in existence for prostate and breast exams. Such a methodology should be designed to facilitate objective early detection and cost-effective treatment of such disorders. In this paper we have reviewed the existing clinical protocols, recent technological advances and suggested reliable clinical workflows for brain screening. Such protocols range from questionnaires and smartphone apps to multi-modality brain mapping and advanced imaging where applicable. To that end, the Society for Brain Mapping and Therapeutics (SBMT) proposes the Brain, Spine and Mental Health Screening (NEUROSCREEN) as a multi-faceted approach. Beside other assessment tools, NEUROSCREEN employs smartphone guided cognitive assessments and quantitative electroencephalography (qEEG) as well as potential genetic testing for cognitive decline risk as inexpensive and effective screening tools to facilitate objective diagnosis, monitor disease progression, and guide personalized treatment interventions. Operationalizing NEUROSCREEN is expected to result in reduced healthcare costs and improving quality of life at national and later, global scales.

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Studies on the Bottom-Up and Top-Down Neural Information Flow Alterations in Neurodegeneration

Cited by 2 publications

References 49 publications

Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice

Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice

A Proposed Brain-, Spine-, and Mental- Health Screening Methodology (NEUROSCREEN) for Healthcare Systems: Position of the Society for Brain Mapping and Therapeutics

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