Studies on the cellular origin of neurothekeoma: Clinical, light microscopic, immunohistochemical, and ultrastructural observations

Barnhill, Raymond L.; Dickersin, G. Richard; Nickeleit, Volker; Bhan, Atul K.; Muhlbauer, Jan E.; Phillips, Murray G.; Mihm, Martín C.

doi:10.1016/0190-9622(91)70177-4

“…Despite the purported hypothesis of this tumor being of neural origin, it fails to stain with S-100 like its classical counterpart. 5,[9][10][11] It has, however, been noted to stain with some neural markers, including PGP 9.5, and, more interestingly, melanocyte markers, including NKI/C3. 11,12 Other studies have shown it to be smooth muscle actin positive (see Table 5).…”

Section: Discussionmentioning

confidence: 99%

Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma

Page

¹

,

King

²

,

Mihm

³

et al. 2004

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While the usual or myxoid-type neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.

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“…Specifically, neurothekeomas have characteristic light microscopic findings and can be subclassified into myxomatous and cellular variants (1,2). The myxomatous type generates large amounts of myxoid matrix and is typically immunoreactive to the S-100 protein (1-3,8).…”

Section: Discussionmentioning

confidence: 99%

Characterization of an intracranial neurothekeoma: case report

Yavuz

¹

,

Köktekir²,

Bayar³

et al. 2010

Turkish Neurosurgery

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AIm: Neurothekeomas are benign tumors of presumed neural sheath origin. They are primarily found in superficial soft tissues, located in the upper portion of the body. Here, we report a case of intracranial neurothekeoma. results:A 37-year-old female presented at our clinic with sudden-onset left hemifacial pain of varying duration. The physical and neurological examination findings were normal. The magnetic resonance imaging scan showed a mass compressing the pons and extending from the medial section of the left middle fossa to the posterior fossa. The patient was operated on using a left presigmoid transpetrosal approach and the mass was totally removed.COnClusIOn: Neurothekeomas, also known as nerve sheath myxomas, are rare benign tumors. There have been two previous cases reported with an intracranial location. The information presented here now represents the third such case in the literature. KeywOrds: Brain tumor, Intracranial, Nerve sheath myxoma, Neurothekeoma ÖZAmAÇ: Nörotekomalar nöral kılıf orjinli iyi huylu tümörlerdir. Genellikle gövdenin üst kısımlarındaki yüzeyel dokularda rastlanır. Biz burada bir intrakranial nörotekoma vakasını sunuyoruz.BulGulAr: 37 yaşında kadın hasta kliniğimize, yüzünün sol yarısında ani başlayan ağrı şikayeti ile başvurdu. Fizik ve nörolojik muayene bulguları normaldi. Kranial MR da sol orta kranial fossadan posterior fossaya doğru uzanan ponsa bası yapan kitle saptandı. Hasta sol presigmoid transpetrosal yaklaşımla opere edildi ve kitle tamamen çıkartıldı. sOnuÇ: Nörotekomalar, diğer bilinen adıyla sinir kılıfı miksomaları, iyi huylu tümörlerdir. Literatürde intrakranial lokalizasyonda bildirilen 2 vaka vardır ve biz burada 3. vakayı sunuyoruz.

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“…This observation should help prevent diagnostic error in classification of cellular neurothekeoma and may be evidence that cellular neurothekeoma is a type of myomelanocytic tumor in the family of perivascular epithelioid cell tumors. 24 11 Colllagen type IV, SMA, calponin S-100, GFAP, CD57, CD34, EMA, NF, p75ngfr, Factor XIIIa Chang et al, 1999 25 1 NKI/C3,SMA, NSE, synaptophysin, chromogranin S-100, CD34, Factor XIIIa, CD68, HMB-45, CK, EMA Zelger et al, 1998 21 15 NKI/C3, KiM1p, PCNA, NSE, Factor XIIIa, SMA, vimentin S-100, CD68, MBp, GFAP, NSE, NF, CD34, CD31, Factor VIII, ulex, desmin, myoglobin, KL1, EMA, E9 Tomasini et al, 1996 26 2 Vimentin, SMA, S-100, HMB-45, NSE, EMA, CK, desmin, CD68 Argenyi et al, 1995 19 11 Collagen type IV, SMA, NSE, vimentin S-100, CD57, GFAP, MBp, NSE, DP keratin, HMB-45, CD34, Factor XIIIa Husain et al, 1994 23 14+ MBP, EMA A-1-ACT, MAC-387, KP-1, SMA Argenyi et al, 1993 20 4 NSE,SMA, CD57 S-100, Collagen IV, GFAP, NF, EMA, MBp, DP keratin, HMB-45, chromogranin, A1-ACT, desmin Calonje et al, 1992 12 9 NKI/C3, NSE, SMA S-100, desmin, EMA, PGP 9.5, HMB-45 Barnhill et al, 1991 9 8 Vimentin S-100, MBP, EMA, GFAP Barnhill and Mihm 1990 16 5 S-100, MBP, EMA, keratin, A1-ACT, lysozyme, A1-AT, Rosati et al, 1986 7 3 S-100, lysozyme, A1-AT, MBP, Factor VIII, keratin, desmin …”

Section: Casementioning

confidence: 99%

Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma

Page

¹

,

King

²

,

Mihm

³

2003

View full text Add to dashboard Cite

While the usual or myxoid-type neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.

show abstract

Studies on the cellular origin of neurothekeoma: Clinical, light microscopic, immunohistochemical, and ultrastructural observations

Cited by 99 publications

References 19 publications

Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma

Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma

Characterization of an intracranial neurothekeoma: case report

Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma

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