Studies on the chemical constituents of Evodia rutaecarpa and Evodia rutaecarpa passed with Liquorice and biological activities

Wang, Q; Shan, Yaso; Chen, Y; Wang, X; Guan, Fuqin; Yin, M.; Sun, Hong; Zhao, Yi Bin; Feng, Xianying; Wang, M

doi:10.1055/s-0032-1320947

Cited by 3 publications

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“…Natural herbs have been widely used in traditional Chinese medicine (TCM) for thousands of years. Recently, TCM has received widespread attention in the world, particularly given its few side effects, multi-target treatments, and natural origin [16,17]. A growing number of studies have indicated that some kinds of natural herbs with multi-target characteristics can successfully treat AD in both in vivo and in vitro models [18,19].…”

Section: Introductionmentioning

confidence: 99%

“…The alkaloids contained in E. rutaecarpa have been reported to have anti-Alzheimer's disease effects. Dehydroevodiamine can attenuate amnesia induced by Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) or scopolamine in mice, ameliorate spatial memory retention impairment in rats [17], and decrease tau hyperphosphorylation [18]. Evodiamine, a main compound in E. rutaecarpa, has neural protective effects: it improves cognitive ability [19], decreases the neurotoxicity of tau aggregation [25], inhibits glial cell activation and neuroinflammation [26], suppresses oxidative stress, and increases serum levels of acetylcholine choline acetyltransferase [27].…”

Section: Introductionmentioning

confidence: 99%

“…A recent study indicated that E. rutaecarpa extract could effectively improve the behavioral performance of learning and memory in AD model mice [17]. There is no clear record of E. rutaecarpa treating AD, though it has been proven to treat migraines and depression in TCM.…”

Section: Introductionmentioning

confidence: 99%

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Elucidation of Pharmacological Mechanism Underlying the Anti-Alzheimer’s Disease Effects of Evodia rutaecarpa and Discovery of Novel Lead Molecules: An In Silico Study

Zhang,

Xu,

Guo

et al. 2023

Molecules

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Alzheimer’s disease (AD) is a brain disease with a peculiarity of multiformity and an insidious onset. Multiple-target drugs, especially Chinese traditional medicine, have achieved a measure of success in AD treatment. Evodia rutaecarpa (Juss.) Benth. (Wuzhuyu, WZY, i.e., E. rutaecarpa), a traditional Chinese herb, has been identified as an effective drug to cure migraines. To our surprise, our in silico study showed that rather than migraines, Alzheimer’s disease was the primary disease to which the E. rutaecarpa active compounds were targeted. Correspondingly, a behavioral experiment showed that E. rutaecarpa extract could improve impairments in learning and memory in AD model mice. However, the mechanism underlying the way that E. rutaecarpa compounds target AD is still not clear. For this purpose, we employed methods of pharmacology networking and molecular docking to explore this mechanism. We found that E. rutaecarpa showed significant AD-targeting characteristics, and alkaloids of E. rutaecarpa played the main role in binding to the key nodes of AD. Our research detected that E. rutaecarpa affects the pathologic development of AD through the serotonergic synapse signaling pathway (SLC6A4), hormones (PTGS2, ESR1, AR), anti-neuroinflammation (SRC, TNF, NOS3), transcription regulation (NR3C1), and molecular chaperones (HSP90AA1), especially in the key nodes of PTGS2, AR, SLCA64, and SRC. Graveoline, 5-methoxy-N, N-dimethyltryptamine, dehydroevodiamine, and goshuyuamide II in E. rutaecarpa show stronger binding affinities to these key proteins than currently known preclinical and clinical drugs, showing a great potential to be developed as lead molecules for treating AD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elucidation of Pharmacological Mechanism Underlying the Anti-Alzheimer’s Disease Effects of Evodia rutaecarpa and Discovery of Novel Lead Molecules: An In Silico Study

Zhang,

Xu,

Guo

et al. 2023

Molecules

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“…(Rutaceae) (ERB). ERB is an important medicinal plant species with several varieties and is known as a traditional Chinese medicine for the treatment of postpartum hemorrhage, amenorrhea, abdominal pain, headache and dysentery 28 . Previous studies have shown that some of the volatile compounds in honey are plant derivatives, 10,12,28 and it is worth investigating whether the volatile chemical composition of ERBH has the same composition and biological activities as the plant.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Evodia rutaecarpa (Juss) Benth honey: volatile profile, odor‐active compounds and odor properties

Li,

Liu,

Shuai

et al. 2023

J Sci Food Agric

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BackgroundAroma is one of the most important quality criterion of different honeys and even defines their merchant value. The composition of volatile compounds, especially the characteristic odor‐active compounds, is an important contributor to honey aroma. Evodia rutaecarpa (Juss) Benth honey (ERBH) is a special honey in China with unique flavor characteristics. However, no work has yet been published in the literature to investigate the volatile compounds and characteristic odor‐active compounds of ERBHs. Therefore, it is necessary to systematically investigate the volatile profile, odor‐active compounds, and odor properties of ERBHs.ResultsThe characteristic fingerprint of ERBHs was successfully constructed with 12 characteristic peaks and a similarity range of 0.785‐0.975. A total of 298 volatile compounds were identified and relatively quantified by headspace solid‐phase microextraction (HS‐SPME) coupled with gas chromatography quadrupole time‐of‐flight mass spectrometry (GC‐QTOF), of which 61 and 31 were identified as odor‐active compounds by relative odor activity values (ROAVs) and GC‐olfactometry (GC‐O) analysis, respectively, especially the common 22 odor‐active compounds (E)‐β‐damascenone, phenethyl acetate, linalool, cis‐linalool oxide (furanoid), octanal, hotrienol, trans‐linalool oxide (furanoid), 4‐oxoisophorone, and eugenol, etc., contributed significantly to the aroma of ERBHs. The main odor properties of ERBHs was floral, followed by fruity, herbaceous, and woody aromas. The partial least‐squares regression (PLSR) results showed that the odor‐active compounds had good correlations with the odor properties.ConclusionIdentifying the aroma differences of different honeys is of great importance. This study provided a reliable theoretical basis for the quality and authenticity of ERBHs.This article is protected by copyright. All rights reserved.

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“…It has the properties of dispersing cold and relieving pain, lowering rebelliousness, and stopping vomiting. It is commonly used in the treatment of syncopal headaches, abdominal pain from cold diseases, vomiting, and acid swallowing, 15 and is classified as a member of the liver, spleen, and stomach meridians. 16 The main active ingredient in Wuzhuyu is evodiamine (EVO).…”

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confidence: 99%

Research Progress on the Anti-Tumor Mechanism and Reversal of Multidrug Resistance of Zuojin Pill and its Main Components, Evodiamine and Berberine

Wang

Tang

Guo

et al. 2023

Natural Product Communications

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Background Cancer is one of the most serious diseases worldwide that threatens human health and leads to death. Chemotherapy is the main clinical method to treat tumors, but, despite the development of new chemotherapeutic drugs, the multidrug resistance (MDR) of cancer cells to conventional chemotherapeutic drugs remains a major cause of failure in cancer prevention and treatment. Therefore, overcoming this resistance has become a major challenge in cancer prevention and treatment. Method With the in-depth study of traditional Chinese medicines (TCMs) for the treatment of tumors, many such medicines have been found that can reverse MDR and enhance the sensitivity of chemotherapy. ZJW is a famous traditional medicine formula from China, recorded first in an ancient medicine book named Danxi Xinfa. It is composed of Huanglian and Wuzhuyu in a ratio of 6:1 by mass. Conclusion ZJW can inhibit proliferation, induce apoptosis, inhibit invasion and metastasis, and reverse MDR of tumor cells through multiple pathways and multiple targets. In this paper, we briefly review recent research on ZJW and its main components, evodiamine and berberine, in the anti-tumor mechanism and reversal of multidrug resistance.

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Studies on the chemical constituents of Evodia rutaecarpa and Evodia rutaecarpa passed with Liquorice and biological activities

Cited by 3 publications

References 0 publications

Elucidation of Pharmacological Mechanism Underlying the Anti-Alzheimer’s Disease Effects of Evodia rutaecarpa and Discovery of Novel Lead Molecules: An In Silico Study

Elucidation of Pharmacological Mechanism Underlying the Anti-Alzheimer’s Disease Effects of Evodia rutaecarpa and Discovery of Novel Lead Molecules: An In Silico Study

Characterization of Evodia rutaecarpa (Juss) Benth honey: volatile profile, odor‐active compounds and odor properties

Research Progress on the Anti-Tumor Mechanism and Reversal of Multidrug Resistance of Zuojin Pill and its Main Components, Evodiamine and Berberine

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