Studies on the Chemical Constituents of Sarcandra glabra

Luo, Yongming; Lin, Feng-Xiang; Du, Yuqian; Li, Hongtao; Jiang, Chenxing; Hua, Liu

doi:10.2991/icimm-15.2015.43

Cited by 3 publications

(9 citation statements)

References 3 publications

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“…Phytochemical research was performed for the leaves of A. schimperi by chromatography and afforded a new triterpenoid ester, lupan-20-ol-3()-yl 3-hydroxyoctadecanoate (1), together with seven known triterpenoids, namely lupeol (2) [9], 28-nor-urs-12-ene-3,17-diol (3) [10], ursolic aldehyde (4) [8], 3-hydroxy-oleana-11,13(18)-dien-28-oic acid (5) [11], alagidiol (6) [12,13], oleanolic acid (7) [14] and ursolic acid lactone (8) [15] (Figure 2). The structures of the known compounds were identified by comparing their spctroscopic data with those reported in the literatures.…”

Section: Resultsmentioning

confidence: 99%

Triterpenoids from Acokanthera schimperi in Ethiopia

Matebie¹,

Zhang²,

Zhang³

et al. 2019

Rec.Nat.Prod.

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The studies on the leaves of Acokanthera schimperi, a traditional herb of Ethiopia, afforded eight triterpenoids, including a new triterpenoid ester, lupan-20-ol-3()-yl 3-hydroxyoctadecanoate (1), along with seven known triterpenoids, lupeol (2), 28-nor-urs-12-ene-3,17-diol (3), ursolic aldehyde (4), 3-hydroxyoleana-11,13(18)-dien-28-oic acid (5), alagidiol (6), oleanolic acid (7) and ursolic acid lactone (8). Their structures were determined by spectroscopic methods including 2D NMR techniques and X-ray diffraction analysis.

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Section: Resultsmentioning

confidence: 99%

Triterpenoids from Acokanthera schimperi in Ethiopia

Matebie¹,

Zhang²,

Zhang³

et al. 2019

Rec.Nat.Prod.

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“…Sarcandroside B C 53 H 86 O 22 212. Lupeol C 30 H 50 O S. glabra, whole plant EtOH [ 53 ] 213. 24-Hydroxylupeol C 30 H 50 O 2 214.…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…Scopoletin C 10 H 8 O 4 S. glabra, whole plant DCM [ 32 , 86 ] 232. Eleutheroside B 1 C 17 H 20 O 10 S. glabra, whole plant EtOH [ 53 ] 233. 3,3′-Biisofraxidin C 22 H 18 O 10 S. glabra, whole plant EtOH [ 85 ] 234.…”

Section: Chemical Constituentsmentioning

confidence: 99%

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A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra

Chu,

Krishnan,

Lim

2023

Nat. Prod. Bioprospect.

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Sarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chloranthaceae family. Indigenous to tropical and subtropical regions of East Asia and India, this species is extensively distributed across China, particularly in the southern regions (Sichuan, Yunnan, and Jiangxi). In addition to its high ornamental value, S. glabra has a rich history of use in traditional Chinese medicine, evident through its empirical prescriptions for various ailments like pneumonia, dysentery, fractures, bruises, numbness, amenorrhea, rheumatism, and other diseases. Besides, modern pharmacological studies have revealed various biological activities, such as antitumour, anti-bacterial, anti-viral anti-inflammatory and immunomodulatory effects. The diverse chemical constituents of S. glabra have fascinated natural product researchers since the 1900s. To date, over 400 compounds including terpenoids, coumarins, lignans, flavonoids, sterols, anthraquinones, organic acids, and organic esters have been isolated and characterised, some featuring unprecedented structures. This review comprehensively examines the current understanding of S. glabra’s phytochemistry and pharmacology, with emphasis on the chemistry and biosynthesis of its unique chemotaxonomic marker, the lindenane-type sesquiterpenoids. Graphical Abstract

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“…Additionally, the IR spectroscopy of IF showed several prominent absorption spectra (KBr) including 3200-3500 cm −1 (the broad peak related to the hydroxyl group (OH − ), 2900-3000 cm −1 (medium, C-H), 1675-1705 cm −1 (strong, C=O), 1570-1600 cm −1 (medium, C=C aromatic), 1600-1680 cm −1 (weak, C=C), and 1030-1300 cm −1 (medium, C-O) [92,93]. In another study, the noticeable results of IR spectroscopy of IF isolated from Sarcandra glabra were included 3298, 2981, 2941, 1705, 1606, 1574, 1302, 1036 that could be interpreted based on the aforementioned results [94]. The range of the chemical shifts (δ) and coupling constants (J) of the 1 H and 13 C NMR study of IF has been shown in Table 2.…”

Section: Identification and Structure Elucidationmentioning

confidence: 99%

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

et al. 2020

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Isofraxidin (7-hydroxy-6, 8-dimethoxy coumarin) (IF) is a hydroxy coumarin with several biological and pharmacological activities. The plant kingdom is of the most prominent sources of IF, which, among them, Eleutherococcus and Fraxinus are the well-known genera in which IF could be isolated/extracted from their species. Considering the complex pathophysiological mechanisms behind some diseases (e.g., cancer, neurodegenerative diseases, and heart diseases), introducing IF as a potent multi-target agent, which possesses several herbal sources and the multiple methods for isolation/purification/synthesis, along with the unique pharmacokinetic profile and low levels of side effects, could be of great importance. Accordingly, a comprehensive review was done without time limitations until February 2020. IF extraction methods include microwave, mechanochemical, and ultrasound, along with other conventional methods in the presence of semi-polar solvents such as ethyl acetate (EtOAc). In addition to the isolation methods, related synthesis protocols of IF is also of great importance. From the synthesis point of view, benzaldehyde derivatives are widely used as precursors for IF synthesis. Along with the methods of isolation and biosynthesis, IF pharmacokinetic studies showed hopeful in vivo results of its rapid absorption after oral uses, leading to different pharmacological effects. In this regard, IF targets varieties of inflammatory mediators including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs). thereby indicating anticancer, cardioprotective, and neuroprotective effects. This is the first review on the synthesis, biosynthesis, isolation, and pharmacokinetic and pharmacological properties of IF in combating different diseases.

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Studies on the Chemical Constituents of Sarcandra glabra

Cited by 3 publications

References 3 publications

Triterpenoids from Acokanthera schimperi in Ethiopia

Triterpenoids from Acokanthera schimperi in Ethiopia

A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

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