1948
DOI: 10.1172/jci101950
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Studies on the Chemotherapy of the Human Malarias. Ix. Effect of Pamaquine on the Blood Cells of Man 123

Abstract: Pamaquine (6-methoxy-8-amino [N-diethylaminoisopentyl] quinoline) is recognized to be a potentially dangerous drug. However, a definitive appraisal of its hazard had not been achieved at a time when the further exploration of the antimalarial activity of the 8-aminoquinolines was considered advisable. Pamaquine toxicity can involve the gastro-intestinal tract, the central nervous system, and the circulating blood. Symptoms referable to the gastro-intestinal tract and the central nervous system may be annoying… Show more

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Cited by 41 publications
(21 citation statements)
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“…Data presented in another paper (6) support this statement as far as leukopenia and methemoglobinemia are concerned. It is, therefore, proposed that the modification of pamaquine disposition effected by quinacrine represents a specific example of a mechanism whereby one drug (quinacrine) potentiates the activity (toxic) of another (pamaquine).…”
Section: Discussionmentioning
confidence: 55%
“…Data presented in another paper (6) support this statement as far as leukopenia and methemoglobinemia are concerned. It is, therefore, proposed that the modification of pamaquine disposition effected by quinacrine represents a specific example of a mechanism whereby one drug (quinacrine) potentiates the activity (toxic) of another (pamaquine).…”
Section: Discussionmentioning
confidence: 55%
“…It was noted that haemolytic reactions occurred sporadically with plasmoquine in patients of Asian, African or South European descent, but were uncommon in Caucasians originating further north [88]. This was explained later by the epidemiology of glucose-6-phosphate dehydrogenase deficiency.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore resistance arose readily to the antifol anti-malarials in P. vivax . Although plasmoquine was moderately effective it was relatively poorly tolerated in the dose regimens necessary to prevent relapse (radical cure) [83-88]. The more effective and better tolerated 8-aminoquinolines pentaquine and then primaquine were developed and evaluated between 1944 and 1955 [122-126].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, black patients were more susceptible to this adverse effect. 3 Similar observations in the 1950s led to the birth of pharmacogenetics; the study of hereditary influences on drug response with Mendel's laws of inheritance and Garrod's "inborn errors of metabolism" providing the theoretical framework.…”
mentioning
confidence: 92%