Studies on the circulation in pregnancy

Thomson, Kate; Hirsheimer, A.; Gibson, John G.; Evans, William A.

doi:10.1016/s0002-9378(38)90870-1

Cited by 122 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The search strategy identified 2266 unique studies (Figure ). Nine articles were added manually as they were reported in a review but were not identified by the literature search. Articles published in languages other than English or Dutch were excluded manually during the first selection ( n = 451).…”

Section: Resultsmentioning

confidence: 99%

Physiological adaptation of maternal plasma volume during pregnancy: a systematic review and meta-analysis

Haas

Ghossein‐Doha

Kuijk

et al. 2017

Ultrasound Obstet Gynecol

194

132

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Physiological adaptation of maternal plasma volume during pregnancy: a systematic review and meta-analysis

Haas

Ghossein‐Doha

Kuijk

et al. 2017

Ultrasound Obstet Gynecol

194

132

View full text Add to dashboard Cite

show abstract

“…The very proinflammatory micro environment have shown causative association in both, inflammation-induced anaemia [21,43] through a mechanism, which down regulates the iron adsorption and erythropoiesis [68] and in infection-induced inflammation mediated anaemia during pregnancy and delivery. During an early pregnancy, a physiologically indispensible and activated mechanism works in such a coordinated fashion that up regulates the blood and plasma volumes [69,70]. The very precisely orchestrated phenomena of increased blood volume observed by Dieckmann and others that the total amount of circulatory haemoglobin at term pregnancy was increased about 13% and total erythrocyte volume increased by 20% [71] leading to relative decrease in haemoglobin concentration and absolute increase in amount during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Maternal and severe anaemia in delivering women is associated with risk of preterm and low birth weight: A cross sectional study from Jharkhand, India

Kumari

Garg²,

Kumar

et al. 2019

One Health

View full text Add to dashboard Cite

Background and objectives Haemoglobin content is the well accepted indicator for anaemia assessment. The high prevalence of anaemia, maternal health care issues and adverse delivery outcome in Jharkhand, we investigated whether delivering women with anaemia would present a modifiable risk of preterm (PTB) and low birth weight (LBW). Methods A facility-based cross-sectional study involving pregnant women, with screening for pregnancy endpoints and haemoglobin assay, were conducted. Anaemia was classified according to World Health Organization's definition of anaemia in pregnancy. Confounding variables were adjusted in a logistic model. The adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were used for analyzing the association among maternal anaemia, PTB and LBW. Results We observed a high prevalence of anaemia (78.45%) in delivering women, whereas high prevalence of preterm birth (34.75%) and LBW (32.81%) in delivering women overall. In the adjusted analysis, overall anaemia in pregnancy was strongly associated with preterm birth (OR, 3.42; 95% CI, 1.98–5.88; P ≤ .0001 ) as compared to LBW (OR, 1.12; 95% CI, 0.65–1.61; P = .0003 ). The risk of PTB and LBW were dependent on the stratification of the anaemia group, as the strongest association was observed in severe (OR, 4.86) followed by mild (OR, 3.66) and moderate (OR, 3.18) anaemia in PTB; whereas risk of LBW was found in severe (OR, 2.5) followed by moderate (OR, 1.11) and mild (OR, 0.57) anaemia. The risk of PTB and LBW across six pregnancy haemoglobin groups were compared, haemoglobin of 10–10.9 g/dl (OR, 1.25) and ≤ 8 g/dl (OR, 1.03) have shown association with PTB and LBW, respectively. However, high haemoglobin concentration was not associated with either PTB or LBW. Conclusions Anaemia in delivering women was associated with an elevated risk of PTB and LBW and the risk increased with the severity of anaemia in pregnant women.

show abstract

“…Only data generated < 30 days before delivery were considered for the purposes of this analysis. Thomson et al (1938) present data on third-trimester blood volume for 11 women (mean ± SD = 5.42 ± 0.92 L). Caton et al (1951) present third-trimester data for 10 women (mean ± SD = 5.74 ± 0.97 L).…”

Section: Derivation Of Probability Distributions For Model Parametersmentioning

confidence: 99%

“…Although these data are relatively old, Hytten (1985) , in summarizing the more recent state of knowledge of blood volume at 40 weeks of pregnancy, reported a value of 5.50 L. The earlier studies thus appear to compare well with more recent data. Thomson et al (1938) also report the measured body weight corresponding to the blood volumes. Third-trimester blood volume and body weight are moderately correlated ( r Spearman = 0.49), but the correlation is marginally significant ( p = 0.13).…”

Section: Derivation Of Probability Distributions For Model Parametersmentioning

confidence: 99%

A Revised Probabilistic Estimate of the Maternal Methyl Mercury Intake Dose Corresponding to a Measured Cord Blood Mercury Concentration

Stern¹

2005

Environ Health Perspect

View full text Add to dashboard Cite

In 2001, the U.S. Environmental Protection Agency (EPA) adopted a revised reference dose (RfD) for methyl mercury (MeHg) of 0.1 μg/kg/day. The RfD is based on neurologic developmental effects measured in children associated with exposure in utero to MeHg from the maternal diet. The RfD derivation proceeded from a point of departure based on measured concentration of mercury in fetal cord blood (micrograms per liter). The RfD, however, is a maternal dose (micrograms per kilogram per day). Reconstruction of the maternal dose corresponding to this cord blood concentration, including the variability around this estimate, is a critical step in the RfD derivation. The dose reconstruction employed by the U.S. EPA using the one-compartment pharmacokinetic model contains two areas of significant uncertainty: It does not directly account for the influence of the ratio of cord blood:maternal blood Hg concentration, and it does not resolve uncertainty regarding the most appropriate central tendency estimates for pregnancy and third-trimester–specific model parameters. A probabilistic reassessment of this dose reconstruction was undertaken to address these areas of uncertainty and generally to reconsider the specification of model input parameters. On the basis of a thorough review of the literature and recalculation of the one-compartment model including sensitivity analyses, I estimated that the 95th and 99th percentiles (i.e., the lower 5th and 1st percentiles) of the maternal intake dose corresponding to a fetal cord blood Hg concentration of 58 μg/L are 0.3 and 0.2 μg/kg/day, respectively. For the 99th percentile, this is half the value previously estimated by the U.S. EPA.

show abstract

Studies on the circulation in pregnancy

Cited by 122 publications

References 9 publications

Physiological adaptation of maternal plasma volume during pregnancy: a systematic review and meta-analysis

Physiological adaptation of maternal plasma volume during pregnancy: a systematic review and meta-analysis

Maternal and severe anaemia in delivering women is associated with risk of preterm and low birth weight: A cross sectional study from Jharkhand, India

A Revised Probabilistic Estimate of the Maternal Methyl Mercury Intake Dose Corresponding to a Measured Cord Blood Mercury Concentration

Contact Info

Product

Resources

About