Studies on the Circulatory Changes in the Dog Produced by Endotoxin From Gram-Negative Microorganisms

Endotoxemia in liver diseases: Detection by a quantitative assay using chromogenic substrate with perchloric acid pretreatment.

“…Among the various biological actions of endotoxin, Chien et al (1964) showed an accelerating effect of endotoxin on capillary permeability to macromolecules. Endotoxin was also shown experimentally to cause portal hypertension by constriction of hepatic venules Weil et al 1956;Chien et al 1964). If the above mentioned effect of endotoxin are present in cirrhotic patients, it is possible for endotoxin to cause the retention of ascites.…”

Noradrenaline and tyramine action on isolated atrial muscle of endotoxin‐treated guinea‐pigs

“…It has been shown that the intravenous administration of E. coli endotoxin to animals produced a progressive fall in aortic blood pressure, a drastic reduction in total blood volume, an increase in total peripheral resistance, a decrease in venous return and a diminished cardiac output (Weil, MacLean, Spink & Visscher, 1956;Heiffer, Mundy & Mehlman, 1960;Cavanagh & Rao, 1969). Changes in cardiac activity are assumed to be secondary to this circulatory response.…”

Effect of Endotoxin on Myocardial Performance

“…The problem of the precise role of the heart in the development of irreversible endotoxin shock is complicated by events occurring in the periphery which most assuredly influence cardiac output adversely (12,26), causing its decrease on the basis of a diminished venuous return. The resultant systemic hypotension may ultimately comprcmise cardiac integrity because of diminished coronary blood flow.…”