Studies on the Constituents from the Aerial Part of Baccharis dracunculifolia DC.

Nagatani, Yoshimi; Warashina, Tsutomu; Noro, Tadataka

doi:10.1248/cpb.49.1388

Cited by 40 publications

(15 citation statements)

References 26 publications

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“…8 B. dracunculifolia is classified into Compositae and indigenous throughout the southeast parts of Latin America and is used by local people as traditional medicine. 10) In Brazil, the local name of B. dracunculifolia is "Alecrim." The plant was reported to be one of the origins of Brazilian propolis by the chemical constituent analysis as described above.…”

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confidence: 99%

Direct Evidence for the Plant Origin of Brazilian Propolis by the Observation of Honeybee Behavior and Phytochemical Analysis

Kumazawa

Yoneda²,

Shibata³

et al. 2003

Chem. Pharm. Bull.

205

154

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Propolis, a natural resinous substance collected by honeybees from buds and exudates of plants, has been considered to be used in the beehive as a protective barrier against their enemies. Recently propolis is extensively used in food and beverages to improve health and prevent diseases. 1)The composition of propolis depends on the place and time of collection. Much research and development has been implemented on propolis all over the world. Most of the recent studies are related to Brazilian propolis because it has been reported to possess a characteristic biological activity.2)It is generally accepted and chemically demonstrated that the bud exudates of poplar trees are the main source of propolis from Europe and China.1) On the other hand, the plant origin of Brazilian propolis has not been clarified, since there are no poplar trees in Brazil. Recently Bankova et al. and Midorikawa et al. have reported that the plants of Baccharis species are important sources of Brazilian propolis.3,4) However their studies were not based on the observation of honeybees, and they only compared the chemical constituents of propolis with those of plants.In this study, we observed the behavior of honeybees in Minas Gerais States of Brazil to identify the plant origin of the propolis directly. Further, we comparatively analyzed the constituents of propolis and the plant leaves by HPLC with PDA (photo-diode array) and MS detection. ExperimentalObserving the Honeybees We observed the honeybees in Minas Gerais, Carvalhopolis in Brazil (SL21.75, WL45.87), where about 20 honeybee colonies were kept. The first and second observations were made on 28-29 Jan. 1998 and on 28-29 Jan. 1999, respectively. We found honeybee workers foraging on plants and recorded the leaf-collecting behavior of honeybees on the plant Baccharis dracunculifolia by VTR. Sampling of Baccharis dracunculifolia and PropolisWe collected the 18 kinds of young leaves of B. dracunculifolia, which the honeybees were chewing and collecting (sample a), and the propolis from the neighboring honeybees' nest (sample b). We compared the constituents of samples a and b by the following procedure.One hundred milligrams of the B. dracunculifolia leaves and propolis was cut to small pieces and extracted with 5 ml of ethanol at room temperature. After 12 h, extracts were filtered with a 0.45 mm filter prior to 10 ml injection into the HPLC system with PDA and MS detection.Apparatus for Analysis The HPLC system consisted of a SI-1 system (Shiseido, Tokyo, Japan) with a PDA detector. For the analysis of the sample, a Capcell Pak UG 120 (Shiseido, Tokyo, Japan) C18 column (2.0ϫ250 mm, 5 mm) was used. The mobile phase consisted of water with 2% acetic acid (A) and acetonitrile with 2% acetic acid (B). The gradient was 20-80% B in 60 min at a flow rate of 0.2 ml/min. UV spectra were recorded from 195-650 nm at a rate of 0.8 spectrum/s and a resolution of 4.0 nm.MS was performed on an LCQ ion trap mass spectrometer (ThermoFinnigan, CA, U.S.A.) equipped with an ESI (electrospray ioniza...

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Section: )mentioning

confidence: 99%

Direct Evidence for the Plant Origin of Brazilian Propolis by the Observation of Honeybee Behavior and Phytochemical Analysis

Kumazawa

Yoneda²,

Shibata³

et al. 2003

Chem. Pharm. Bull.

205

154

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“…Three active glycosides (including sinenoside 1 89), which afford protection to red blood cell membranes to resist hemolysis induced by the peroxyl radical initiator 2,2′-azo-bis-(2amidinopropane) dihydrochloride, were isolated from Ligustrum sinense (102). Dracunculifoside K 90 and N 91, and 10 other glycosides were isolated from the aerial part of Baccharis dracunculifolia (Compositae); these compounds have an (E)-caffeoyl group like dracunculifosides A-J, which were reported previously (103).…”

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confidence: 99%

Astonishing diversity of natural surfactants: 5. Biologically active glycosides of aromatic metabolites

Dembitsky

2005

Lipids

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This review article presents 342 aromatic glycosides, isolated from and identified in plants and microorganisms, that demonstrate different biological activities. They are of great interest, especially for the medicinal and/or pharmaceutical industries. These biologically active natural surfactants are good prospects for the future chemical preparation of compounds useful as antioxidant, anticancer, antimicrobial, and antibacterial agents. These glycosidic compounds have been classified into several groups, including simple aromatic compounds, stilbenes, phenylethanoids, phenylpropanoids, naphthalene derivatives, and anthracene derivatives.

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“…Caffeoyl quinic acid derivatives are characteristic of Asteraceae (Clifford, 2000), and have been reported in extracts of Baccharis trimera, Baccharis crispa and Baccharis usteri (Simões-Pires et al, 2005), Baccharis dracunculifolia (Nagatani et al, 2002) and Baccharis gaudichaudiana (Akaike et al, 2003). Fractions F8 (10-100 M), identified as an ent-clerodane diterpene (diterpene 2) , and F9 (10-300 g/ml), mainly consisting of flavonoids (Torres et al, 2000;Tanae et al, 2008) decreased the basal [ 14 C]-AP uptake at the highest concentrations (by 52% and 58% of control, respectively).…”

Section: Resultsmentioning

confidence: 98%

Antisecretory actions of Baccharis trimera (Less.) DC aqueous extract and isolated compounds: Analysis of underlying mechanisms

Biondo

Tanae

Coletta

et al. 2011

Journal of Ethnopharmacology

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The results indicate that Baccharis trimera presents constituents that inhibit gastric acid secretion by acting mainly on the cholinergic regulatory pathway. The plant extract also contains compounds that exert moderate inhibition of the histaminergic regulatory pathway of acid secretion and the gastric proton pump. Altogether these active constituents appear to provide effective inhibition of acid secretion in vivo, which may explain the reputed antiulcer activity of the plant extract.

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Studies on the Constituents from the Aerial Part of Baccharis dracunculifolia DC.

Cited by 40 publications

References 26 publications

Direct Evidence for the Plant Origin of Brazilian Propolis by the Observation of Honeybee Behavior and Phytochemical Analysis

Direct Evidence for the Plant Origin of Brazilian Propolis by the Observation of Honeybee Behavior and Phytochemical Analysis

Astonishing diversity of natural surfactants: 5. Biologically active glycosides of aromatic metabolites

Antisecretory actions of Baccharis trimera (Less.) DC aqueous extract and isolated compounds: Analysis of underlying mechanisms

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