Studies on the Depressed Hemolytic Complement Activity of Synovial Fluid in Adult Rheumatoid Arthritis

Hedberg, H.

doi:10.3109/rhe1.1963.9.issue-1-4.21

Cited by 59 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elution of rheumatoid synovium using acid pH or high ionic-strength buffers has yielded predominantly IgG and albumin and C3 (21,22), and complexes rich in IgG and containing IgG and IgM rheumatoid factors have been identified. Striking diminution in CH50 (23)(24)(25) and C2 (26) has been recorded by both single radial diffusion and stoichiometric hemolytic titrations (27,28). Further evidence for the activation of late components including a reduction of C9 in seropositive patients has been noted more recently (29).…”

Section: Discussionmentioning

confidence: 92%

Synovial fluid lymphocytes in rheumatoid arthritis

Utsinger

1975

Arthritis & Rheumatism

View full text Add to dashboard Cite

There is significant evidence implicating immunologic mechanisms in the pathogenesis of rheumatoid arthritis (RA). To investigate the possibility that a cellular imbalance of T and B lymphocytes plays a role in perpetuating synovitis, an examination of the peripheral blood and synovial fluid lymphocytes of patients with seropositive rheumatoid arthritis was undertaken. A significant lymphopenia was encountered in RA patients, with values approximately midway between those in normal controls and the severe lymphopenia seen in a group of patients with systemic lupus erythematosus. A significantly greater diminution of T than B cells was noted in RA, and normal percentage distributions of lymphocytes in peripheral blood were documented. Normal percentages of T and B cells, similar to those in peripheral blood, were found in synovial fluids of patients with seropositive RA, seronegative RA, osteoarthritis, and gout. Two seropositive patients ex-

show abstract

Section: Discussionmentioning

confidence: 92%

Synovial fluid lymphocytes in rheumatoid arthritis

Utsinger

1975

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…The first studies of synovial fluid complement activity in disease observed that to make meaningful comparisons, it was necessary to make a correction for total synovial fluid protein (1,2). Thus it was described that corrected complement activity in synovial fluids of patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) were lower than predicted by total protein (1,2).…”

mentioning

confidence: 99%

“…Corrected complement levels in fluids from patients with gout and Reiter's disease are said to be the same or greater than those of DJD (1)(2)(3)5,9,11,13,14). Any sizable overlap of ranges diminishes the usefulness of complement determinations for diagnosis or for identification of new syndromes in which complement activation plays a pathogenetic role.…”

mentioning

confidence: 99%

“…Measurements of hemolytic complement activity and of individual complement proteins in synovial fluid have been used as investigational tools in studies of the pathogenesis of joint inflammation and have been advocated as useful in the diagnosis of arthritis (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The first studies of synovial fluid complement activity in disease observed that to make meaningful comparisons, it was necessary to make a correction for total synovial fluid protein (1,2).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Immunoelectrophoretic assay for synovial fluid C3 with correction for synovial fluid globulin

Hasselbacher

1979

Arthritis & Rheumatism

View full text Add to dashboard Cite

Synovial fluid C3 was measured by electroimmunoassay. When C3 was expressed as mg/ml, the amounts found in Reiter's disease, psoriatic arthritis, gout, and systemic lupus erythematosus were significantly different from degenerative arthritis. When C3 was corrected for total protein, the levels for rheumatoid arthritis, Reiter's disease, psoriatic arthritis, and systemic lupus were significantly different from degenerative arthritis. When C3 was corrected for synovial fluid globulin, only rheumatoid arthritis and systemic lupus were significantly different from degenerative arthritis. Correction of C3 for globulin increases the difference between rheumatoid arthritis and degenerative arthritis. A proportion of gouty fluids with a relative decrease in C3 is demonstrated. It is argued that correction of C3 for globulin is more meaningful than correction for total

show abstract

“…Chronic inflammation is a characteristic feature of the chronic arthritis diseases, and there is now convincing evidence that the complement system is activated in both seropositive (Hedberg, 1963(Hedberg, , 1964(Hedberg, , 1967Pekin & Zvaifler, 1964;Fostiropoulis, Austen & Bloch, 1965;Barnett, Bienenstock & Bloch, 1966;Peltier, Coste & Delbarre, 1966; Vaughan, Barnett, Sobel & Jacox, 1968;Zvaifler, 1969; Ruddy & Austen, 1970;Hedberg, Lundh & Laurell, 1970;Gligore, Bolishu, Duter & Podut, 1971; Ruddy, Everson, Schur & Austen, 1971; Ruddy, Muller-Eberhard & Austen, 1971; Britton & Schur, 1971; Ward & Zvaifler, 1971;Versey, Hobbs & Holt, 1973;and seronegative (Whaley, Canesi, Moseley, Morrow, Sturrock, Mitchell & Dick, 1974) arthritides. As there is at present no cure for these disorders, treatment is simply symptomatic.…”

Section: Introductionmentioning

confidence: 99%

Studies of the action of some anti‐inflammatory drugs on complement mediated immune haemolysis.

Whaley¹,

Sloane²

1975

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 The effects of various anti‐inflammatory and non‐anti‐inflammatory drugs on complement mediated haemolysis have been studied. Drugs which were significantly protein bound were found to inhibit this form of immune lysis, but only at greater concentrations than achieved therapeutically. 2 Removal of the drugs by prolonged dialysis resulted in restoration of complement activity with the exceptions of phenylbutazone and warfarin sodium. 3 Reconstitution experiments indicated that C2 and some of the later components especially C7 were affected by the drugs. 4 Intra‐articular injections of prednisolone (100 mg) in patients with rheumatoid arthritis, failed to produce significant changes in the synovial fluid complement system. 5 None of the drugs affected the binding of antibody to antigen, or the ability of sensitized sheep cells to fix complement.

show abstract

Studies on the Depressed Hemolytic Complement Activity of Synovial Fluid in Adult Rheumatoid Arthritis

Cited by 59 publications

References 24 publications

Synovial fluid lymphocytes in rheumatoid arthritis

Synovial fluid lymphocytes in rheumatoid arthritis

Immunoelectrophoretic assay for synovial fluid C3 with correction for synovial fluid globulin

Studies of the action of some anti‐inflammatory drugs on complement mediated immune haemolysis.

Contact Info

Product

Resources

About