Studies on the Development and Evaluation of Colon Targeted Mesalamine Tablets based on Eudragit L100-Chitosan Interpolyelectrolye Complexes

Begum, M. Yasmin; Bandarupalli, Kiran Kumar; Sirisha, Ch.; Kavitha, Athota; Sudhakar, M.

doi:10.5958/0974-360x.2017.00228.1

Cited by 2 publications

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“…Thickness. Randomly selected 10 tablets were tested for thickness in mm using digital micrometer, and its mean value was recorded along with its standard deviation [23].…”

Section: Precompression Parametersmentioning

confidence: 99%

Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100

Begum

Alqahtani

Ghazwani

et al. 2021

International Journal of Polymer Science

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The purpose of the research was to optimize the preparation of duloxetine hydrochloride (duloxetine HCl) delayed release tablets. Duloxetine HCl produces a toxic substance called alpha-naphthol when duloxetine HCl is in contact with gastric fluid. Thus, duloxetine HCl when given orally needed a protective enteric coating that disable the delivery of duloxetine HCl in gastric fluid while enabling the drug delivery only in small intestine. Four different core tablets were prepared by direct compression technique, and the one which displayed quick disintegration and dissolution was chosen for enteric coating. The compressed tablets were enteric coated by dip coating technique. Since subcoating is required to safeguard the enteric coating, the core tablets were subcoated by using polymer HPMC K15M and then enteric coated with Eudragit L 100. The prepared tablets were assessed for the entire precompression and postcompression characteristics. FTIR study revealed the existence of all prominent peaks signifying its compatibility and authenticity. The in vitro studies showed that enteric-coated tablets were capable of restricting release in acidic media. The formulation F8 was optimised with 5% and 15% increase in weight of seal coat and enteric coat with good dissolution profile. Stability studies revealed that the optimized formulation was intact without any deterioration for 3 months. In conclusion, the optimized formulation could resist the drug release in acidic environment of gastrointestinal region and release the drug at a time once the tablet reaches the intestine.

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“…Thickness. Randomly selected 10 tablets were tested for thickness in mm using digital micrometer, and its mean value was recorded along with its standard deviation [23].…”

Section: Precompression Parametersmentioning

confidence: 99%

Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100

Begum

Alqahtani

Ghazwani

et al. 2021

International Journal of Polymer Science

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Formulation development and Evaluation of Colon Specific Delivery System of Anti- amoebic Drug (Tinidazole) using different Polysaccharide carriers

Mathew

Abraham

Sabu

et al. 2022

RJPT

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Amoebiasis is an infection of the large intestine caused by Entamoeba histolytica. Tinidazole is the preferred drug used in the treatment of intestinal amoebiasis. The conventional tablet dosage form provides minimal amount of drug in the colon with undesirable adverse effect due to variation in the transit time. Hence, to target the drug directly to the site of action in the colon, there is need to develop colon targeted drug delivery systems that will enhance the therapeutic drug level, increases the bioavailability of active medicament and reduce the dose of drug. The fast disintegrating core tablet of Tinidazole was prepared by direct compression method. The core tablet was evaluated for hardness, thickness, Friability, weight variation, drug content, in vitro disintegration time and in vitro drug release studies. Using the optimized formulation (C3), different formulations (F1-F6) of coated tablet was prepared by using different polymers like chitosan and xanthan gum. The formulated coated tablet were evaluated for various parameters like for hardness, thickness, Friability, weight variation, drug content, swelling study and in vitro dissolution study. The optimized formulation F3 shows 6.24% drug release in Stomach and Small Intestine and maximum drug release up to 96.53% in the colon. The kinetic data analysis of formulations indicated that it fits to Korsmeyer -Peppas Model and follows zero order release kinetics. The mechanism of drug release from the tablet followed non-Fickian (super case-11) transport. The stability studies of the optimized formulation were investigated as per ICH guidelines. There were no significant changes in thickness, hardness, weight variation, friability, drug content and in vitro drug release. These findings suggest that compression coated tablet using polysaccharide carriers provide more site specific delivery, reduced degradation and release of drug in stomach and small intestine.

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Studies on the Development and Evaluation of Colon Targeted Mesalamine Tablets based on Eudragit L100-Chitosan Interpolyelectrolye Complexes

Cited by 2 publications

References 0 publications

Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100

Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100

Formulation development and Evaluation of Colon Specific Delivery System of Anti- amoebic Drug (Tinidazole) using different Polysaccharide carriers

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