“…It has therefore been suggested that acetohydroxamic acid (AHA), a potent inhibitor of various bacterial ureases including H pylon urease,1 be incorporated into therapeutic regimens aimed at eradicating H pylori. Synergistic effects between AHA and various antimicrobial agents against Hpyloni in vitro have recently been reported by Phillips et al in this journal, making this approach even more attractive.2 As we have observed that AHA enhances the cytotoxic effects produced by H pyloni, we would like to add a cautionary note to the discussion on the possible use of AHA for treatment of H pylon infection as suggested by Mooney et al 3and again by Munster et al4 We have been looking at the cytotoxic effects produced by supernatant fluids of H pylon sonicates on HeLa cells in a quantitative microtitre cytotoxicity assay, performed in a modification of a test described by Gentry et al5 Briefly, sterile filtered (0 45…”