This investigation was carried out in two successive seasons (2007 and 2008) on 20 year old pomegranate cv. Manfalouty (Punica granatum L.) trees grown at El-Kassasien Research Station, Ismailia Governorate in sandy soil under drip irrigation system. The experiment was designed to study the response of pomegranate trees to different irrigation levels and their effect on vegetative growth and fruit quality. The trees received the following five irrigation levels: 7, 9, 11, 13 or 15 m 3 /tree/year. The results indicated that the highest irrigation level of 15m 3 /tree/year enhanced vegetative growth by increasing shoots length, number of leaves per shoot and leaf area. Also, it increased the number of flowers per shoot, fruit set, fruit retention, fruit dimensions, fruit volume, fruit grains, yield and fruit cracking. Using irrigation level of 13 m 3 /tree/year recorded the highest leaf mineral contents of N, P, K and Ca. Also, increased fruit juice, TSS/ acid ratio and water use efficiency (WUE) and gave the lowest fruit cracking. Meanwhile, using the lowest irrigation level of 7 m 3 /tree/year decreased vegetative growth, yield and fruit weight, with increasing fruit cracking, fruit TSS, acidity, sugar, V.C. and anthocyanin content.