Studies on the effect of monosodium glutamate (MSG) administration on the activity of xanthine oxidase, superoxide dismutase and catalase in hepatic tissue of adult male mice

Singh, Kuldip; Ahluwalia, Preeti

doi:10.1007/bf02867938

Cited by 14 publications

(9 citation statements)

References 21 publications

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“…These will result in a decrease of cell pH that will affect and damage the lysosome membrane, resulting in the breakdown of lysosomes and the release of enzymes into the cytoplasm. 32 On the other hand, a decrease in ATP production will also decrease Na + K + ATPase function. This situation will lead to an accumulation of intracellular Na+ and increases the cellular osmotic pressure.…”

Section: Discussionmentioning

confidence: 99%

Reversible Hepatotoxicity of Cassytha filiformis Extract: Experimental Study on Liver Function and Propofol-Induced Sleep in Mice

Yuliandra¹,

Armenia²,

Arief³

et al. 2019

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A concept in traditional medicine called 'natural is safe' has been developing and led the massive use of herbal products for health benefits. This concept in some cases is not only far from the truth, but can also be dangerous. Some of the most toxic substances to human body come from nature. When a synthetic drug that contains a single active chemical substance can be toxic, more potential toxic effects are likely expected from a natural herb which may contain hundreds of chemical compounds. 1 Many cases of serious adverse reactions from the consumption of herbal medicine have been reported across the globe. 2-4 In addition, the adverse reactions of herbal medicine are also experienced by patients treated in hospital settings who receive conventional medications. 5 Undesired effects of traditional medicine may include allergic reactions, toxic reactions and interactions. These effects can be due to several factors, such as inappropriate doses and length of use, bacterial or other chemical contaminations and mistaken plant identities. The safe use of traditional medicines has been a major concern since they have led to several adverse reactions that can be life-threatening. 6-8 Therefore, it is necessary

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Section: Discussionmentioning

confidence: 99%

Reversible Hepatotoxicity of Cassytha filiformis Extract: Experimental Study on Liver Function and Propofol-Induced Sleep in Mice

Yuliandra¹,

Armenia²,

Arief³

et al. 2019

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“…45 Both GSH and SOD are abundant in the liver and they participate in cell protection against ROS and against cancer development. 43,46 SOD catalyzes the breakdown of the superoxide anion into oxygen and hydrogen peroxide and GSH detoxifies hydrogen peroxide in presence of GSH peroxidase. 47 Sun et al 48 observed an inhibition in SOD activity in EAC-bearing animals that may be attributed to loss of mitochondria and loss of Mn SOD activity in EAC cells, resulting in a lowering in total hepatic SOD activity.…”

Section: Discussionmentioning

confidence: 99%

Regression of murine Ehrlich ascites carcinoma using synthesized cobalt complex

et al. 2017

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Cisplatin as a chief chemotherapy has nephro-toxicity and so we have tried to develop a novel antitumor drug based on a combination of cobalt metal ion with an organic moiety. The antitumor activity of the complex was tested and against murine Ehrlich ascites carcinoma (EAC). Antioxidant capacity and nucleic acids content were determined. Cobalt(ii) diacetyl monoxime-2-hydrazinopyridine complex significantly diminished tumor load. It decreased the tumor proliferation rate and obviously increased the life span of EAC-bearing mice. It reversed the haematological parameters back towards normal, reduced liver enzymes and urea, and increased albumin and total protein. Antioxidant parameters levels were reversed towards normal. An assessment was conducted by comparing these results with those obtained using the standard drug, cisplatin. The results suggest that the cobalt complex can be considered as a potent anticancer agent as it showed appreciable antitumor activity in EAC-bearing mice that was almost analogous to that of the reference standard, cisplatin.

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“…SOD are a class of closely related enzymes that catalyze the breakdown of the superoxide anion into oxygen and hydrogen peroxide (Zelko et al, 2002). The amount of SOD is organ specific and it is abundant in hepatic tissue (Singh and Ahluwalia, 2002). CAT is a key component of the antioxidant defense system.…”

Section: Discussionmentioning

confidence: 99%

Extract of Coelatura aegyptiaca, a freshwater clam, ameliorates hepatic oxidative stress induced by monosodium glutamate in rats

Soliman¹

2011

Afr. J. Pharm. Pharmacol.

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The purpose of the present work was to evaluate the possible ameliorative effect of Coelatura aegyptiaca extract (CE) and vitamin C on oxidative stress induced by monosodium glutamate (MSG) in rat liver. Male rats were randomly divided into four main groups: control group, received distilled water, group 2 (100 mg/kg) and 3 (250 mg/kg) received CE for seven consecutive days. Group animals (24 rats) were administered MSG (4 mg/g body weight) daily for 10 days. This group was then subdivided into 4 subgroups. All subgroups treated orally for 7 days with, distilled water (subgroup I), CE at a dose of 100 and 250 mg/kg body weight (subgroups II and III), and 250 mg vitamin C/kg body weight (subgroup IV). Furthermore, the antioxidant activity of the CE was determined using a DPPH (2,2-diphenyl-1picrylhydrazyl) test system. The CE and vitamin C caused significant ameliorative effects by decreasing the activities of serum aminotransaminases (AST and ALT), alkaline phosphatase (ALP), levels of serum glucose, lipid profile parameters, liver malondialdeyde level (MDA), nitric oxide (NO), superoxide dismutase activity (SOD), as well as the activity of liver catalase (CAT), and increasing the level of liver glutathione reduced (GSH). The results of the present study elucidate that CE could ameliorate the liver oxidative stress induced by MSG administration, since CE was strongly scavenged DPPH radicals and showed antioxidant activity.

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Studies on the effect of monosodium glutamate (MSG) administration on the activity of xanthine oxidase, superoxide dismutase and catalase in hepatic tissue of adult male mice

Cited by 14 publications

References 21 publications

Reversible Hepatotoxicity of Cassytha filiformis Extract: Experimental Study on Liver Function and Propofol-Induced Sleep in Mice

Reversible Hepatotoxicity of Cassytha filiformis Extract: Experimental Study on Liver Function and Propofol-Induced Sleep in Mice

Regression of murine Ehrlich ascites carcinoma using synthesized cobalt complex

Extract of Coelatura aegyptiaca, a freshwater clam, ameliorates hepatic oxidative stress induced by monosodium glutamate in rats

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