Studies on the effect of polyhedral carboranes on the physicochemical properties of polycarboranosiloxanes

Minyaylo, Ekaterina O.; Zubova, V. Y.; Зайцев, А. В.; Ol’shevskaya, V. A.; Никифорова, Г. Г.; Бузин, М. И.; Анисимов, А. А.; Музафаров, А. М.

doi:10.1039/d2py01539k

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“…The full structure of the first generation 4-G1 and the linear structure with parentheses of the fifth generation 4-G5 are displayed in Scheme 6 [ 28 ]. The thermal properties and the rheological behavior of these dendrimers in relation with analogous polymers were recently compared [ 29 ].…”

Section: Boron Clusters On the Surface Of Dendrimersmentioning

confidence: 99%

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

2023

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The presence of a large number of boron atoms in boron clusters make them attractive tools for the treatment of cancer using boron neutron capture therapy (BNCT). Since the quantity of boron atoms present in the target cell directly affects the effectiveness of BNCT, the idea of gathering a high number of boron atoms in a single entity has emerged many years ago. In this perspective, using hyper-branched macromolecules such as dendrimers appears as an interesting solution. In this review, we will first present the synthesis of diverse dendritic entities (dendrimers, dendrons, and Janus dendrimers) that incorporate boron clusters, in particular carboranes, anywhere in their structure. Four parts of this review present the synthesis of dendrimers having boron clusters on the surface, or inside their structure, of dendrons and of Janus dendrimers, bearing boron clusters. Practically all these boronated dendritic structures were synthesized with the objective to study their biological properties, but in fact only a few of them have been tested against cancerous cells, and even a smaller number was tested in BNCT experiments. The biological experiments are discussed in the fifth part of this review. A good efficiency is generally observed with the boronated dendrimers, even in animal models, with an increase in their mean survival time (MST).

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Section: Boron Clusters On the Surface Of Dendrimersmentioning

confidence: 99%

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

2023

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show abstract

Studies on the effect of polyhedral carboranes on the physicochemical properties of polycarboranosiloxanes

Abstract: In this work, polycarboranosiloxanes (Mn = 25.5 – 31.3 kDa) with well-defined structures and with a various content of carborane moieties (2 – 15 wt. %) were obtained. The TGA...

Cited by 1 publication

References 56 publications

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

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