Studies on the effect of alcohols on the chiral discrimination mechanisms of amylose stationary phase on the enantioseparation of nebivolol by HPLC

Aboul‐Enein, Hassan Y.; Ali, Imran

doi:10.1016/s0165-022x(01)00148-8

Cited by 117 publications

(58 citation statements)

References 33 publications

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“…Kummer et al [15] investigated the chiral separation of 26 steroids using an AD When IPA (isopropyl alcohol) was added to the eluent, the separation factor increased from 1.4 (MeOH-H 2 O or CH 3 CN-H 2 O as mobile phase) to 1.6. It has been reported that IPA could change the structure of higher order of the derivatized amylose and influenced the enantioselectivity of the chiral stationary phase [16]. This conclusion was reasonable according to our results from the experiment.…”

Section: Introductionsupporting

confidence: 91%

Enantiomeric Separation of Fluoxetine Derivatives on Polysaccharide‐Based Chiral Columns

Mei-Li

Jie-Guo

2006

Archiv der Pharmazie

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A high performance liquid chromatography (HPLC) method employing amylose-based chiral columns (Chiralpak AD-RH and Chiralpak AD) and cellulose-based chiral columns (Chiralcel OD) as chiral stationary phases have been developed for the enantiomeric separation of fluoxetine (FLX) derivatives. The FLX was derivatized with 4-(N-chloroformylmethyl-N-methyl)amino-7-nitro-2,1,3-benzoxadiazole (NBD-COCl) and 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole (DBD-COCl), respectively. Influence of the mobile phase composition and column temperature on the enantioseparation was discussed during the separation. On the basis of separation of derivatized FLX enantiomers, the paper also discussed the separation mechanism on the chiral stationary phases used.

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Section: Introductionsupporting

confidence: 91%

Enantiomeric Separation of Fluoxetine Derivatives on Polysaccharide‐Based Chiral Columns

Mei-Li

Jie-Guo

2006

Archiv der Pharmazie

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“…This is due to the polar component competing with the analyte for interaction with the CSP. 15 Although many studies on the chiral resolution by the polysaccharide-based CSP have been reported, the chiral …”

Section: Results and Discussion The Chiral Separationsmentioning

confidence: 99%

The direct chiral separations of fungicide enantiomers on amylopectin based chiral stationary phase by HPLC

et al. 2006

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Amylopectin-tris(phenylcarbamate) was synthesized and coated to aminopropylsilica to prepare chiral stationary phase. The chiral separations of fungicide enantiomers were performed by the CSP using high-performance liquid chromatography. Mobile phase was n-hexane and isopropanol, and flow rate was 1.0 ml/min. Detection wavelength was 230 nm. The influence of the percentage of isopropanol in the mobile phase on the separations was studied. Twelve chiral fungicides were tested and seven of them were found to show stereoselectivity on the CSP. The enantiomers of metalaxyl and benalaxyl got near baseline separations and myclobutanil, hexconazole, tebuconazole, uniconazole, and paclobutrazol enantiomers were completely separated. The decreasing percentage of isopropanol in the mobile phase resulted in better separation and longer analysis time. The enantiomers were identified by a circular dichroism (CD) detector and the CD spectra of the individual enantiomers were also studied by online scanning.

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“…According to the diverse substituted groups, OPs with only one chiral centre on a phosphorus atom can be divided into several subclasses, such as phosphates (temivinphos (1) and Nexion (2)), phosphonates and phosphonothioates (EPN (3), EPBP (4), leptophos (5), trichloronate (6), fonofos (7), cyanofenphos (8), inezin (9) and fosamine (10)), phosphoro(di)thiolates (prothiofos (11), sulprofos (12), profenofos (13), pyraclofos (14), Bopardil RM60 (15), diphenprophos (16), tebupirimfos (17), conen (18) and cereton B (19)), phosphoramidothioates (methamidophos (20), acephate (21), fenamiphos (22), crufomate (23), isocarbophos (24), isofenphos (25), isofenphos-methyl (26), propetamphos (27), Dow-ET15 (28), amidothionate (29) and amiprophos-methyl (30)), and cyclic phosphates (salithion (31)). The structures of these compounds are presented in Figs.…”

Section: Chiral Phosphorus Centresmentioning

confidence: 99%

Enantiomeric separation of organophosphorus pesticides by high-performance liquid chromatography, gas chromatography and capillary electrophoresis and their applications to environmental fate and toxicity assays

Zhou

Jin

et al. 2010

Journal of Chromatography B

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Studies on the effect of alcohols on the chiral discrimination mechanisms of amylose stationary phase on the enantioseparation of nebivolol by HPLC

Cited by 117 publications

References 33 publications

Enantiomeric Separation of Fluoxetine Derivatives on Polysaccharide‐Based Chiral Columns

Enantiomeric Separation of Fluoxetine Derivatives on Polysaccharide‐Based Chiral Columns

The direct chiral separations of fungicide enantiomers on amylopectin based chiral stationary phase by HPLC

Enantiomeric separation of organophosphorus pesticides by high-performance liquid chromatography, gas chromatography and capillary electrophoresis and their applications to environmental fate and toxicity assays

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