Studies on the efficacy of lipoate and dihydrolipoate in the alteration of cadmium2+ toxicity in isolated hepatocytes

Müller, Ludwig; Menzel, H.

doi:10.1016/0167-4889(90)90147-6

Cited by 54 publications

(15 citation statements)

References 26 publications

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“…They regenerate other antioxidants (i.e. vitamin E, vitamin C and GSH) from their radical or inactive forms and also have metal chelating activity (Devasagayam et al 1993;Mu¨ller and Menzel 1990). On the other hand, the dithiol DMSA has specific affinity for lead as a chelator with antioxidative properties (Gurer and Ercal 2000).…”

Section: Discussionmentioning

confidence: 99%

Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney

Sivaprasad

Nagaraj

Varalakshmi

2002

Archives of Toxicology

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The deleterious effect of lead has been attributed to lead-induced oxidative stress with the consequence of lipid peroxidation. The present study was designed to investigate the combined effect of DL-alpha-lipoic acid (LA) and meso-2,3-dimercaptosuccinic acid (DMSA) on lead-induced peroxidative damages in rat kidney. The increase in peroxidated lipids in lead-poisoned rats was accompanied by alterations in antioxidant defence systems. Lead acetate (Pb, 0.2%) was administered in drinking water for 5 weeks to induce lead toxicity. LA (25 mg/kg body weight per day i.p.) and DMSA (20 mg/kg body weight per day i.p.) were administered individually and also in combination during the sixth week. Nephrotoxic damage was evident from decreases in the activities of gamma-glutamyl transferase and N-acetyl beta- D-glucosaminidase, which were reversed upon combined treatment with LA and DMSA. Rats subjected to lead intoxication showed a decline in the thiol capacity of the cell, accompanied by high malondialdehyde levels along with lowered activities of catalase, superoxide dismutase, glutathione peroxidase and glutathione metabolizing enzymes (glutathione reductase, glucose-6-phosphate dehydrogenase, glutathione- S-transferase). Supplementation with LA as a sole agent showed considerable changes over oxidative stress parameters. The study has highlighted the combined effect of both drugs as being more effective in reversing oxidative damage by bringing about an improvement in the reductive status of the cell.

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Section: Discussionmentioning

confidence: 99%

Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney

Sivaprasad

Nagaraj

Varalakshmi

2002

Archives of Toxicology

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“…Meat is an important source of a-lipoic acid, which is absorbed from the gastrointestinal tract (Harrison & McCormick, 1974), but can also be synthesised (Carreau, 1979). a-Lipoic acid can interfere with lipid peroxidation by competing for free transition metals as a chelator (Muller & Menzel, 1990) and by scavenging hydroxyl radicals (Suzuki et al, 1991). On the other hand, DHLA can scavenge peroxyl radicals (Kagan et al, 1992).…”

Section: Thiol-based Antioxidantsmentioning

confidence: 99%

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Meeteren¹,

Teunissen

Dijkstra

et al. 2005

Eur J Clin Nutr

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“…Chemically synthesized LA, in contrast, is a racemate (a mixture of equal amount of R-and S-LA), and is believed to exert additional beneficial bioactivities when administered exogenously. These include anti-oxidative activities such as chelating metals (Muller et al, 1990), scavenging reactive oxygen species (ROS) (Matsugo et al, 1995), recycling / inducing endogenous anti-oxidants (Konishi et al, 1996), anti-inflammation (Fuchs et al, 1994), activation of cell signaling (Packer et al, 2011), and enhancement of glucose uptake (Konrad et al, 2001). It was also reported that LA had a pro-oxidant activity which leads to cellular adaptation against oxidative stress (Cakatay, 2006).…”

Section: Introductionmentioning

confidence: 99%

α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion

Yamada

Hashida

Takarada-Iemata

et al. 2011

Neurochemistry International

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Growing evidence suggests that -lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of LA enantiomers (R-and S-LA) are not fully clarified.We, therefore, estimated the neuroprotective effects of LA against different cellular stresses including oxidative stress, endoplasmic reticulum (ER) stress and proteolytic stress using

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Studies on the efficacy of lipoate and dihydrolipoate in the alteration of cadmium2+ toxicity in isolated hepatocytes

Cited by 54 publications

References 26 publications

Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney

Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion

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